Seroprevalence of hepatitis E virus infection among volunteer blood donors in Central Brazil

Weis-Torres, Sabrina Moreira dos Santos; França, Adriana de Oliveira; Granato, Celso; Passarini, Amanda; Motta-Castro, Ana Rita Coimbra

doi:10.1016/j.bjid.2022.102350

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Brazilian Journal of Infectious Diseases

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Brief Communication • Braz J Infect Dis 26 (02) • 2022 • https://doi.org/10.1016/j.bjid.2022.102350 copy

Seroprevalence of hepatitis E virus infection among volunteer blood donors in Central Brazil^☆ ☆ The institutions at which the work was performed: UFMS and FIOCRUZ-MS, Campo Grande: conceive and design the study, collect, and store the blood samples, statistical analysis and draft the article. UNIFESP: serological analysis.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

A cross-sectional study was carried out in the Hematology and Hemotherapy Institute of the state of Mato Grosso do Sul (Hemosul) to evaluate the seroprevalence and risk factors of Hepatitis E Virus (HEV) exposure among volunteer blood donors in Central Brazil. Two-hundred fifty samples from the biorepository were tested for anti-HEV IgG and IgM using the Wantai HEV ELISA test. The seroprevalence of HEV exposure was 6.4% (95% CI: 3.9–10.2). Being born in another state of Brazil, mainly in the Southeast and South regions, was associated with a higher risk of HEV exposure (p < 0.001).

Keywords
Hepatitis E virus; Blood donors; Prevalence

Variable	Total (n= 250)		HEV exposure (n= 16)
Variable	N	%	n	%	OR	95% CI	p-value
Age (years)
≤30	128	51.2	4	3.1
>30	122	48.8	12	9.8	3.38	1.06–10.80	0.040
Sex
Female	78	31.2	4	5.1
Male	172	68.8	12	7.0	1.39	0.43‒4.45	0.582
Born in another state
No	188	75.2	5	2.7
Yes	62	24.8	11	17.7	7.89	2.62–23.76	<0.001 ^a a After multiple logistic regression, being born in another state of Brazil was independently associated with HEV exposure (OR = 6.57; p = 0.001). OR: Odds Ratio; CI: Confidence Interval.
Monthly income (R$)
<2000	114	45.6	10	8.8
≥2000	136	54.4	6	4.4	0.48	0.17‒1.36	0.168
Educational level (years)
>9	215	86.0	12	5.6
≤9	35	14.0	4	11.4	2.18	0.66–7.20	0.200
Rural area
No	205	82.0	11	5.4
Yes	45	18.0	5	11.1	2.20	0.72‒6.69	0.163
Vegetable/kitchen garden
No	163	65.2	10	6.1
Yes	87	38.4	6	6.9	1.13	0.40‒3.23	0.815
Pig herds
No	226	90.4	15	6.6
Yes	24	9.6	1	4.2	0.61	0.08‒4.84	0.641
Sewage access
No	134	53.6	12	9.0
Yes	116	46.4	4	3.5	0.36	0.11‒1.16	0.087

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E-mail: bjid@bjid.org.br

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[1] ☆
The institutions at which the work was performed: UFMS and FIOCRUZ-MS, Campo Grande: conceive and design the study, collect, and store the blood samples, statistical analysis and draft the article. UNIFESP: serological analysis.