Gimmler-Luz, Maria Clara; Erdtmann, Bernardo

doi:10.1590/S0100-84551997000300008

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Brasil

Brazilian Journal of Genetics

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Animal genetics • Braz. J. Genet. 20 (3) • Set 1997 • https://doi.org/10.1590/S0100-84551997000300008 copiar

Clastogenic activity of integerrimine determined in mouse micronucleus assays

Autoria SCIMAGO INSTITUTIONS RANKINGS

A ação clastogênica de duas concentrações (18,75 e 37,5 mg/kg) do alcalóide pirrolizidínico integerrimina, obtido do Senecio brasiliensis, foi testada em camundongos após diferentes tempos do tratamento agudo. Após este tratamento, o alcalóide foi capaz de induzir aumento na freqüência de eritrócitos policromados micronucleados presentes tanto na medula óssea quanto no sangue periférico

Sociedade Brasileira de Genética Rua Capitão Adelmio Norberto da Silva, 736, 14025-670 Ribeirão Preto SP - Brazil, Tel. / Fax: +55 16 621.8540, 620.1251, 620.1253 - Ribeirão Preto - SP - Brazil
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		No. of animals
Dose (mg/kg)	Sample time^a	T	S	A	Sex	No. of analyzed PCE	mPCE/1000 PCE (individual data)	Mean ± SD	PCE/NCE ± SD
N. Control		4	4	4	M	8,000	3.5, 3, 4.5, 3.5	3.6 ± 1.30	0.86 ± 0.42
		5	5	5	F	10,000	5, 5.5, 4.5, 0, 1	3.0 ± 2.71	1.10 ± 0.52
PA	24 h	5	5	4	M	8,000	5, 8, 8.5, 4.5	6.5 ± 2.38*	0.50 ± 0.16
(18.75)		5	5	5	F	10,000	1, 4, 4, 1, 2	2.4 ± 1.52	0.48 ± 0.23
	48 h	5	5	5	M	10,000	6, 5, 4, 2.5, 5	4.6 ± 1.67	0.65 ± 0.17
		5	5	5	F	10,000	4, 8, 5, 6, 4	5.4 ± 1.67*	0.52 ± 0.18
	72 h	5	4	4	M	8,000	8, 4, 4, 4	5.0 ± 2.00*	0.70 ± 0.18
		5	5	5	F	10,000	2.5, 6, 4, 5, 3.5	4.2 ± 1.48	0.60 ± 0.43
PA	24 h	5	5	4	M	8,000	5.5, 2.3, 5.5, 3	4.0 ± 1.67	0.79 ± 0.14
(37.50)		5	5	5	F	10,000	8.5, 4.5, 3.5, 3.5, 7.6	5.5 ± 2.37*	0.78 ± 0.16
	48 h	5	5	5	M	10,000	6, 6, 6.5, 8.5, 7	6.8 ± 1.30*	0.85 ± 0.44
		5	5	5	F	10,000	0.5, 3.5, 4.5, 3, 5	3.3 ± 1.75	0.76 ± 0.38
	72 h	5	4	4	M	8,000	2.5, 3, 2.5, 3.5	2.9 ± 0.48	0.54 ± 0.28
		5	5	5	F	10,000	5, 3, 2, 3, 6	3.8 ± 1.64	0.55 ± 0.20
P. Control	24 h	9	9	9	M	18,000	23, 19, 31, 18, 28.19, 34.5, 23, 22.3	24.2 ± 5.76*	0.61 ± 0.22
		7	7	7	F	14,000	33, 16, 18, 13.5, 20, 40, 27.3	24.0 ± 9.78*	0.59 ± 0.19
	48 h	5	5	5	M	10,000	15.5, 17, 13, 9.5, 11.5	13.3 ± 3.01*	0.31 ± 0.06*
		5	5	5	F	10,000	15, 12.5, 6.5, 11, 8	10.6 ± 3.42*	0.39 ± 0.30*

Dose (mg/kg)	Sample time^a	No. of animals			Sex	No. of analyzed PCE	mPCE/1000 PCE (individual data)	Means ± SD	PCE/NCE ± SD
Dose (mg/kg)	Sample time^a	T	S	A	Sex	No. of analyzed PCE	mPCE/1000 PCE (individual data)	Means ± SD	PCE/NCE ± SD
N. Control		9	9	8	M	24,000	3, 3, 1, 3.5, 2.5, 1, 1.5, 0	1.9 ± 1.24	55.20 ± 17.98
		10	10	10	F	25,000	1, 1, 2, 2, 1, 0, 1, 0.5, 1, 1	1.0 ± 0.60	76.20 ± 26.18
PA	24 h	5	5	4	M	8,000	8.6, 4.6, 7.5, 7.5	7.1 ± 1.71*	66.00 ± 42.70
(18.75)		5	5	4	F	6,000	1, 1, 2, 2	1.5 ± 0.58	46.00 ± 12.98*
	48 h	11	11	10	M	17,000	3, 2.5, 2.5, 2, 3, 1, 1, 1, 3, 1	2.0 ± 0.91	53.82 ± 22.71
		10	10	10	F	14,000	1.5, 2.5, 1, 3, 1, 0, 4.2, 1, 1	1.7 ± 1.18	60.38 ± 24.24
	72 h	5	4	4	M	5,000	2, 1, 4, 4	2.3 ± 1.99	61.50 ± 20.61
		5	5	5	F	5,000	2, 2, 1, 1, 1	1.4 ± 0.55	52.60 ± 12.78
	4 d	6	6	6	M	6,000	0, 3, 1, 0, 1, 5	1.7 ± 1.97	75.33 ± 18.99
		5	5	5	F	5,000	4, 1, 1, 3, 4	2.6 ± 1.52*	73.20 ± 22.95
	7 d	6	6	4	M	4,000	1, 0, 1, 0	0.5 ± 0.58	87.80 ± 61.11
		5	5	4	F	4,000	0, 1, 0, 0	0.3 ± 0.50	56.40 ± 12.99
	14 d	6	6	5	M	5,000	4, 4, 2, 1, 1	2.4 ± 1.52	55.20 ± 30.24
		5	5	4	F	4,000	2, 1, 1, 2	1.5 ± 0.58	43.40 ± 28.17
	21 d	6	6	5	M	5,000	0, 0, 1, 0, 0	0.2 ± 0.45	61.17 ± 15.00
		5	5	5	F	5,000	2, 0, 0, 0, 1, 0	0.6 ± 0.89	53.25 ± 2.99
PA	24 h	5	4	4	M	8,000	3.5, 7.5, 1.5, 6.5	4.7 ± 2.92*	41.80 ± 8.66
(37.50)		5	5	5	F	5,000	6, 6, 2, 2, 7	4.6 ± 2.41*	57.80 ± 32.97
	48 h	12	12	10	M	14,000	5.5, 4, 7, 7, 10, 6, 4, 10, 7, 11	7.2 ± 2.47*	46.60 ± 23.86
		11	11	11	F	15,000	2.5, 5, 6, 6.5, 6.5, 7, 12, 4, 5, 5, 1	5.5 ± 2.81*	50.50 ± 13.16
	72 h	5	4	4	M	7,000	4.5, 3.5, 4, 2	3.5 ± 1.27	38.00 ± 10.12
		5	5	5	F	7,000	3, 1, 4, 1.5, 5	2.9 ± 1.67*	45.70 ± 5.86*
	4 d	7	6	6	M	6,000	3, 2, 3, 2, 3, 3	2.7 ± 0.52	99.00 ± 25.18*
		6	6	6	F	5,000	2, 1, 6, 0, 0, 1	1.7 ± 2.25	93.80 ± 12.00
	7 d	7	6	5	M	5,000	1, 0, 2, 5, 6	2.8 ± 2.59	29.00 ± 1.73*
		6	6	4	F	4,000	1, 1, 1, 2	1.3 ± 0.50	37.00 ± 9.86*
	14 d	7	6	5	M	5,000	0, 1, 3, 1, 2	1.4 ± 1.14	63.40 ± 19.76
		6	6	5	F	5,000	1, 4, 3, 2, 1	2.2 ± 1.30	49.20 ± 19.03
	21 d	7	6	5	M	5,000	2, 0, 0, 0, 0	0.4 ± 0.89	63.50 ± 15.72
		6	6	6	F	6,000	0, 0, 0, 0, 1, 0	0.2 ± 0.41	47.80 ± 7.86*
P. Ccontrol	24 h	5	5	5	M	5,000	9, 10, 9, 5, 12	9.0 ± 2.55*
		5	5	5	F	9,000	10, 9, 9, 9.5, 10	9.5 ± 0.50*
	48 h	5	5	5	F	5,000	23, 35, 24, 26, 29	27.5 ± 4.83*	46.20 ± 12.40
		5	5	5	F	5,000	13, 19, 22, 12, 21	17.4 ± 4.62*	37.40 ± 13.26*