Effects of liquid extract from <i>Plinia cauliflora</i> fruits residues on Chinese hamsters biochemical parameters

Plinia cauliflora (Mart.) Kausel, popularly known as jabuticaba, is rich in polyphenols. Phenolic compounds exhibit several biological properties, which reflect on biomarkers such as biochemical parameters. In the present study, we evaluated the plasmatic levels of glucose, total cholesterol, HDL-cholesterol, triglycerides, and uric acid of Chinese hamsters fed for 45 days with a regular diet or cholesterol-enriched diet supplemented with a liquid extract obtained from P. cauliflora fruits residues standardized in ellagic acid and total phenolic compounds. The results showed that the concentrated extract obtained from jabuticaba residues increased the glycemia of animals fed with a regular diet and reduced the plasmatic uric acid levels of animals fed with a cholesterol-enriched diet. Since hyperuricemia is considered to be a significant risk factor of metabolic disorders and the principal pathological basis of gout, the liquid extract from P. cauliflora fruits residues would be a promising candidate as a novel hypouricaemic agent for further investigation.

Keywords:
biochemical parameters; Cerrado; glycemia; jabuticaba; Myrciaria cauliflora; uric acid

Authorship

Leonardo Luiz Borges

Universidade Estadual de Goiás – UEG, Câmpus Central, Laboratório de Estudos Botânicos e Pesquisa de Produtos Naturais, Anápolis, GO, BrasilUniversidade Estadual de GoiásBrasilAnápolis, GO, BrasilUniversidade Estadual de Goiás – UEG, Câmpus Central, Laboratório de Estudos Botânicos e Pesquisa de Produtos Naturais, Anápolis, GO, Brasil

https://orcid.org/0000-0003-2183-3944

Frederico Severino Martins

Universidade de São Paulo – USP, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Ribeirão Preto, SP, BrasilUniversidade de São PauloBrasilRibeirão Preto, SP, BrasilUniversidade de São Paulo – USP, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Ribeirão Preto, SP, Brasil

https://orcid.org/0000-0002-0680-3643

João José Franco

Elisa Flávia Luiz Cardoso Bailão

Universidade Estadual de Goiás – UEG, Câmpus Central, Laboratório de Biotecnologia, Anápolis, GO, BrasilUniversidade Estadual de GoiásBrasilAnápolis, GO, BrasilUniversidade Estadual de Goiás – UEG, Câmpus Central, Laboratório de Biotecnologia, Anápolis, GO, Brasil

https://orcid.org/0000-0001-6737-7548

Wilson de Melo Cruvinel

Pontifícia Universidade Católica de Goiás – PUC Goiás, Escola de Ciências Médicas e da Vida, Laboratório de Produtos Naturais, Goiânia, GO, BrasilPontifícia Universidade Católica de GoiásBrasilGoiânia, GO, BrasilPontifícia Universidade Católica de Goiás – PUC Goiás, Escola de Ciências Médicas e da Vida, Laboratório de Produtos Naturais, Goiânia, GO, Brasil

https://orcid.org/0000-0002-3903-0499

Sérgio Akira Uyemura

https://orcid.org/0000-0001-5505-9817

Edemilson Cardoso da Conceição

Universidade Federal de Goiás – UFG, Faculdade de Farmácia, Goiânia, GO, BrasilUniversidade Federal de GoiásBrasilGoiânia, GO, BrasilUniversidade Federal de Goiás – UFG, Faculdade de Farmácia, Goiânia, GO, Brasil

https://orcid.org/0000-0003-4113-2686

*e-mail: leonardo.borges@ueg.br

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (4)

Thumbnail

Figure 1
Blood glucose in Chinese hamsters' groups. RD= animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE. * represents statistical differences obtained by the t-test (p<0.05) between groups that received or not the extract (RD x E-RD or CD x E-CD).

Thumbnail

Figure 2
Plasmatic triglycerides in Chinese hamsters' groups. RD = animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE.

Thumbnail

Figure 3
Plasmatic total cholesterol (A); HDL-cholesterol (B) in Chinese hamsters' groups. RD = animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE.

Thumbnail

Figure 4
Plasmatic uric acid in Chinese hamsters' groups. RD = animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE. An asterisk represents statistical differences obtained by the t-test (p<0.05) between groups that received or not the extract (RD x E-RD or CD x E-CD).

Figure 1 Blood glucose in Chinese hamsters' groups. RD= animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE. * represents statistical differences obtained by the t-test (p<0.05) between groups that received or not the extract (RD x E-RD or CD x E-CD).

Figure 2 Plasmatic triglycerides in Chinese hamsters' groups. RD = animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE.

Figure 3 Plasmatic total cholesterol (A); HDL-cholesterol (B) in Chinese hamsters' groups. RD = animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE.

Figure 4 Plasmatic uric acid in Chinese hamsters' groups. RD = animals received a regular diet; E-RD = animals received a regular diet with the concentrated liquid extract from jabuticaba residues; CD = animals received a cholesterol-enriched diet; E-CD = animals received a cholesterol-enriched diet with the concentrated liquid extract from jabuticaba residues. Data are presented as mean±SE. An asterisk represents statistical differences obtained by the t-test (p<0.05) between groups that received or not the extract (RD x E-RD or CD x E-CD).

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Effects of liquid extract from <i>Plinia cauliflora</i> fruits residues on Chinese hamsters biochemical parameters

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[1] *e-mail: leonardo.borges@ueg.br