Chang et al. (2022)CHANG, W., LIU, P.-Y., YEH, S. and LEE, H., 2022. Effects of dried onion powder and quercetin on obesity-associated hepatic menifestation and retinopathy. International Journal of Molecular Sciences, vol. 23, no. 19, pp. 11091. http://dx.doi.org/10.3390/ijms231911091. http://dx.doi.org/10.3390/ijms231911091...
|
Sprague Dawley |
Male; 4 weeks |
Fat: 43% |
12 weeks |
-Allium cepa L.
|
12 weeks |
1% e 5% dried onion; |
Onion powder Effects: |
17/20 |
- The onion pieces were lyophilized at 40°C for 24 hrs and gridded into fine poder. The quercetin was determined using high performance liquid chromatography. |
180 mg/kg quercetin |
- 1%, 5% and 180mg/kg quercetin: |
|
= Energy intake; |
|
↓ Epididymal, Perirenal and Mesenteric Mass; |
|
↓Total cholesterol, TG, LDL, Free fatty acid; |
|
↓TNF-α, IL-6, TBARS; |
|
↓Total cholesterol, TG, TNF-α, IL-6, TBARS in liver; |
|
- 1% or 5%: |
|
↓Subcutaneous adipose; adipocyte area epididymal; |
|
↑SOD and Catalase; |
|
↓scores for damage of hepatic; protein expression of ACC-α and Ras; |
|
Feces: ↑Acetic and Butyric acid; Total cholesterol and TG; |
|
↓accumulation of lipids in the retina |
Momoh et al. (2022)MOMOH, B.J., OKERE, S.O. and ANYANWU, G.O., 2022. The anti-obesity effect of Allium cepa L. leaves on high fat diet induced obesity in male wistar rats. Clinical Complementary Medicine and Pharmacology., vol. 2, no. 3, pp. 100035. http://dx.doi.org/10.1016/j.ccmp.2022.100035. http://dx.doi.org/10.1016/j.ccmp.2022.10...
|
Wistar |
Male, Age not informed |
Fat: 50% |
12 weeks |
-Allium cepa L.
|
28 days (4 weeks) |
10% and 20% |
Onion leaves Effects: |
17/20 |
- The onion leaves were sliced into tiny pieces and dried at temperature of 22 ± 2 ◦C, and blended into powder. |
- 10% and 20%: |
= food intake; |
↓ Body Weight; Fat mass; |
↓ AST; Creatinine, Urea; glucose; |
=HDL; Uric acid; |
↓ Accumulation of lipids in liver; |
↓ Kidney inflammation; |
- 20%: |
↓Kidney weight; ALT; |
↓Total cholesterol, TG, LDL, and VLDL. |
Yu et al. (2021)YU, S., LI, H., CUI, T., CUI, M., PIAO, C., WANG, S., JU, M., LIU, X., ZHOU, G., XU, H. and LI, G., 2021. Onion (Allium cepa L.) peel extract effects on 3T3-L1 adipocytes and high-fat diet-induced obese mice. Food Bioscience, vol. 41, pp. 101019. http://dx.doi.org/10.1016/j.fbio.2021.101019. http://dx.doi.org/10.1016/j.fbio.2021.10...
|
C57BL/6J |
Male, 6-8 weeks |
Fat: 34.9% (Soybean Oil and Lard) |
8 weeks |
-Allium cepa L.
|
8 weeks |
36 mg/kg; 90 mg/kg; 144 mg/kg; |
Yellow onion peel extract Effects: |
16/20 |
- Yellow onion peel. The extraction with 5 L distilled water for 5 h at 80 ◦C. |
- High and medium dose group (144mg/kg and 90mg/kg): |
↓ Body Weight; |
- Low, medium, and High dose group (36mg/kg, 90mg/kg and 144mg/kg): |
=Liver Mass; ↓Total cholesterol, TG and LDL; =HDL; ↓Total cholesterol, TG in liver; |
↓ Accumulation of lipids in liver; |
↓ Epididymal adipocytes; |
↓ PPARγ, C/EBPα, FAS, ACC, AP2, and SREBP1 expression; |
↓ PPARγ protein expression |
Grzelak-Błaszczyk et al. (2020)GRZELAK-BŁASZCZYK, K., MILALA, J., KOLODZIEJCZYK, K., SÓJKA, M., CZARNECKI, A., KOSMALA, M., KLEWICKI, R., FOTSCHKI, B., JURGOŃSKI, A. and JUŚKIEWICZ, J., 2020. Onion protocatechuic acid and quercetin glucosides attenuate changes induced by high fat diet in rats. Food & Function, vol. 4, no. 4, pp. 3585-3597. http://dx.doi.org/10.1039/C9FO02633A. http://dx.doi.org/10.1039/C9FO02633A...
|
Wistar |
Male; 4 weeks |
Fat: 14% (Palm oil) |
4 weeks |
- No informed; |
4 weeks |
- HF+ Quercetin diglycosides = 0.44%; |
HF+ Quercetin diglycosides Effects: |
16/20 |
- Yellow onion residues. The extraction with 50% water solution of ethanol, temperature was 35°C; time was 6 h. |
- HF+ Quercetin monoglycosides = 0.34%; |
↑ pH of digesta; |
- HF+ protocatechuic acid = 0.25% |
↑ β-glucosidase day 7; ↓ β-galactosidase days 3,7,14 and 28; ↓ β-glucuronidase; ↓isovaleric and butyric; ↓ Total SCFA; |
|
↓ Liver Mass; ↓creatinine; |
|
HF+ Quercetin monoglycosides Effects: |
|
↓ Diet intake; |
|
↑ β-glucosidase day 3,7,14 and 28; ↑β-glucuronidase day 7,14 and 28; ↓ propionic and isobutyric; ↑Total SCFA; |
|
↓TG and atherogenic index II; |
|
HF+ protocatechuic acid Effects: |
|
↑β-glucuronidase day 7 and 28; ↓Total SCFA; ↓Liver Mass; |
|
↓Total cholesterol, TG and atherogenic index I and II; ↑HDL; ↓Uric acid. |
Grzelak-Błaszczyk et al. (2018)GRZELAK-BŁASZCZYK, K., MILALA, J., KOSMALA, M., KOŁODZIEJCZYK, K., SÓJKA, M., CZARNECKI, A., KLEWICKI, R., JUŚKIEWICZ, J., FOTSCHKI, B. and JURGOŃSKI, A., 2018. Onion quercetin monoglycosides alter microbial activity and increase antioxidant capacity. The Journal of Nutritional Biochemistry, vol. 56, pp. 81-88. http://dx.doi.org/10.1016/j.jnutbio.2018.02.002. PMid:29518727. http://dx.doi.org/10.1016/j.jnutbio.2018...
|
Wistar |
Male; 4 weeks |
Fat: 14% (Palm oil) |
4 weeks |
- No informed; |
4 weeks |
- HF+ Quercetin= 0.21%; |
HF+ Quercetin Effects: |
15/20 |
- Yellow onion residues. The extraction with 50% water solution of ethanol, temperature was 35°C; time was 6 h. |
- HF+ Quercetin monoglycosides = 0.36%; |
= Body Weight; |
|
↓mass of colon tissue; |
|
↓Sucrase and Maltase; ↑lactose; ↑β-glucosidase, β-glucuronidase and β-galactosidase;↑SCFA (acetic, propionic and butyric); |
|
=TBARS; |
|
↑antioxidant capacity of lipid and of water fraction of serum; |
|
= glucose and AST; ↓ALT and atherogenic index II and urea. |
|
HF+ Quercetin monoglycosides Effects: |
|
= Body Weight; |
|
↓pH of digesta cecum and colon; |
|
↓ mass of colon tissue; |
|
↓Sucrase; ↑lactose; ↑β-glucosidase, β-glucuronidase and β-galactosidase; |
|
↑antioxidant capacity of water fraction of serum; |
|
↓ALT and atherogenic index II. |
Emamat et al. (2018)EMAMAT, H., FOROUGHI, F., EINI-ZINAB, H. and HEKMATDOOST, A., 2018. The effects of onion consumption on prevention of nonalcoholic fatty liver disease. Indian Journal of Clinical Biochemistry, vol. 33, no. 1, pp. 75-80. http://dx.doi.org/10.1007/s12291-017-0636-7. PMid:29371773. http://dx.doi.org/10.1007/s12291-017-063...
|
Sprague ‐ Dawley |
Male; |
Fat: 59%; |
7 weeks |
- No informed; |
7 weeks |
7% |
↓ALT, AST, TG, glucose and insulin; |
14/20 |
Age not informed |
Carbohydrate: 30%; |
- Whole yellow onion powder. During powder processing, the leaves were heated to 200 ºC for 15 s and mechanically crushed into fragments of 500–2000µm. |
= LDL-C e Total cholesterol; |
|
Protein: 11% |
↓TNF-α gene expression in liver; |
|
|
↓ degree of hepatic steatosis in lobular and portal inflammation; |
|
|
= weight gain; |
|
|
#NOME? |
Forney et al. (2018)FORNEY, L.A., LENARD, N.R., STEWART, L.K. and HENAGAN, T.M., 2018. Dietary quercetin attenuates adipose tissue expansion and inflammation and alters adipocyte morphology in a tissue-specific manner. International Journal of Molecular Sciences, vol. 19, no. 3, pp. 895. http://dx.doi.org/10.3390/ijms19030895. PMid:29562620. http://dx.doi.org/10.3390/ijms19030895...
|
C57BL/6J |
Gender not informed; 5 weeks |
Fat: 45%; |
9 weeks |
- No informed; |
9 weeks |
17mg/kg |
Red onion extract Effects: |
15/20 |
- Red onion extract in 80% ethanol, lyophilized to obtain the powder. |
↓weight of inguinal and epididymal adipose tissue; ↓size of inguinal and epididymal adipocytes; ↑density of inguinal and epididymal adipocytes; |
↓Cd11b and Cd68, =Mcp-1 and F4/80 (inguinal); |
↑Cd11b, ↓Cd68 and Mcp-1 and =F4/80 (epididymal); |
= leptin and adiponectin; ↓ IL-6; |
↑ multilocular adipocytes (inguinal). |
Quercetin Effects: |
↓weight of inguinal and epididymal adipose tissue; ↓size of epididymal adipocytes; ↑ density of epididymal adipocytes; |
↓Cd11b and Cd68, =Mcp-1 and F4/80 (inguinal); |
=Cd11b, ↑Cd68, ↓Mcp-1 and =F4/80 (epididymal); |
↑ multilocular adipocytes (inguinal). |
Yang et al. (2018)YANG, C., LI, L., YANG, L., LǙ, H., WANG, S. and SUN, G., 2018. Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet. Nutrition & Metabolism, vol. 15, no. 1, pp. 43. http://dx.doi.org/10.1186/s12986-018-0275-x. PMid:29951108. http://dx.doi.org/10.1186/s12986-018-027...
|
Sprague ‐ Dawley |
Male; |
Casein: 20%; Sucrose: 25.3%; Fiber: 4%; |
- No informed; |
-Allium cepa L.;
|
60 days (8 weeks) |
46.3 mg /kg/d and 92.6 mg/kg/ d |
Onion Oil Effects: |
15/20 |
Age not informed |
Lard: 10%; |
- To obtain the oil, the onion bulbs were minced, soaked in distilled water 1.5 times at 35 °C for 2.5 h. |
↓ weight gain; ↓ Lee index; |
|
Custard powder: 5%; |
↓ weight of epididymal and perirenal adipose tissue; |
|
Cholesterol:1.5% |
- High dose group (92.6mg/kg/d):↓TG, Total cholesterol and LDL-C; |
|
|
- High dose group (92.6mg/kg/d):↑HDL-C; |
|
|
↓ atherosclerosis index; |
|
|
↓ degree of hepatic steatosis; |
|
|
= food intake; |
|
|
↑ liver and kidney relative weight. |
Devarshi et al. (2017)DEVARSHI, P.P., JONES, A.D., TAYLOR, E., STEFANSKA, B. and HENAGAN, T.M., 2017. Quercetin and quercetin-rich red onion extract alter Pgc-1𝛼 promoter methylation and splice variant expression. PPAR Research, vol. 2017, pp. 3235693. PMid:28191013.
|
C57BL / 6J |
Male; 5 weeks |
Fat: 45% |
9 weeks |
- No informed; |
9 weeks |
- 17mg/kg |
↓ gene expression Pgc-1α-a;
|
out/20 |
- Red onion peel extracts |
↑ gene expression NT-Pgc-1α; |
|
↓ gene expression FL-Pgc-1α.
|
Lee et al. (2017)LEE, S.G., PARKS, J.S. and KANG, H.W., 2017. Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes. The Journal of Nutritional Biochemistry, vol. 42, pp. 62-71. http://dx.doi.org/10.1016/j.jnutbio.2016.12.018. PMid:28131896. http://dx.doi.org/10.1016/j.jnutbio.2016...
|
C57BL / 6 |
Male; 4 weeks |
Fat:60% |
8 weeks |
- No informed |
8 weeks |
0.50% |
#NOME? |
16/20 |
- Onion peels were washed and air-dried overnight. Onion peel were pulverized for 3 min with 1 L of 60% aqueous ethanol as the extracting solvent. |
= expression PPARγ and FAS (epididymal, retroperitoneal and subcutaneous adipose tissue); = TBX1 and CPT1α (epididymal, retroperitoneal and subcutaneous adipose tissue); |
↓ expression ACC (epididymal); |
↑ PRDM16, PGC1α and UCP1 (retroperitoneal); |
↑ CIDEA (retroperitoneal and subcutaneous) |
Emamat et al. (2016)EMAMAT, H., FOROUGHI, F., EINI–ZINAB, H., TAGHIZADEH, M., RISMANCHI, M. and HEKMATDOOST, A., 2016. The effects of onion consumption on treatment of metabolic, histologic, and inflammatory features of nonalcoholic fatty liver disease. Journal of Diabetes and Metabolic Disorders, vol. 15, no. 1, pp. 25. http://dx.doi.org/10.1186/s40200-016-0248-4. PMid:27453880. http://dx.doi.org/10.1186/s40200-016-024...
|
Sprague ‐ Dawley |
Male; |
Fat:59%; |
7 weeks |
- No informed; |
4 weeks |
7% |
↑ weight gain – control group + onion; |
13/20 |
Age not informed |
Carbohydrate: 30%; |
- Whole yellow onion powder. During powder processing, the leaves were heated to 200 ºC for 15 s and mechanically crushed into fragments of 500–2000µm. |
↑ food intake – control group + onion; |
|
Protein: 11% |
↓ ALT, TG, glucose and insulin; |
|
|
↓ TNFα gene expression in liver; |
|
|
#NOME? |
Henagan et al. (2015)HENAGAN, T.M., CEFALU, W.T., RIBNICKY, D.M., NOLAND, R.C., DUNVILLE, K., CAMPBELL, W.W., STEWART, L.K., FORNEY, L.A., GETTYS, T.W., CHANG, J.S. and MORRISON, C.D., 2015. In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity. Genes & Nutrition, vol. 10, no. 1, pp. 451. http://dx.doi.org/10.1007/s12263-014-0451-1. PMid:25542303. http://dx.doi.org/10.1007/s12263-014-045...
|
C57BL / 6J |
Gender not informed; 5 weeks |
Fat:45% |
9 weeks |
- No informed; |
9 weeks |
17mg |
Red onion extract and Quercetin Effects: |
15/20 |
- Red onion extract in 80% ethanol, lyophilized to obtain the powder. |
= food intake; |
↓ body weight; ↓percent fat mass; ↑ muscle mass; ↓ insulin test; |
↑Energy expenditure; ↓ respiratory |
exchange ratio; ↑ Mitochondrial number; |
#NOME? |
determined by measuring acid |
soluble metabolites (ASM); |
↓ Nd3, Nd4, Cox1 and Atp8 (Only quercetin). |
Matsunaga et al. (2014)MATSUNAGA, S., AZUMA, K., WATANABE, M., TSUKA, T., IMAGAWA, T., OSAKI, T. and OKAMOTO, Y., 2014. Onion peel tea ameliorates obesity and affects blood parameters in a mouse model of high-fat-diet-induced obesity. Experimental and Therapeutic Medicine, vol. 7, no. 2, pp. 379-382. http://dx.doi.org/10.3892/etm.2013.1433. PMid:24396409. http://dx.doi.org/10.3892/etm.2013.1433...
|
BALB/c |
Male; 4 weeks |
Fat: 32% |
28 days (4 weeks) |
- No informed; |
28 days (4 weeks) |
5% |
Effects of onion peel tea: |
11/20 |
- lyophilized onion peel tea containing 1.15 mg / g quercetin |
↓ body weight and weight of epididymal adipose tissue; |
↓ total cholesterol on day 14 and glucose and leptin on day 28. ↓ TG on day 14 and 28; ↑alkaline phosphatase on day 28; |
= ALT, AST, GGT or Alb on days 14 or 28. |
Moon et al. (2013)MOON, J., DO, H.-J., KIM, O.Y. and SHIN, M.J., 2013. Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats. Food and Chemical Toxicology, vol. 58, pp. 347-354. http://dx.doi.org/10.1016/j.fct.2013.05.006. PMid:23684756. http://dx.doi.org/10.1016/j.fct.2013.05....
|
Sprague ‐ Dawley |
Male;5 weeks |
Fat: 40% |
8 weeks |
- No informed; |
8 weeks |
0.36% e 0.72% |
Effects of onion extract (0.36% and 0.72%) on the high fat diet showed: |
14/20 |
Sucrose: 34% |
- Onion peel extracts extracted with 60% aqueous ethanol solution (50 ° C, 3 hours). |
↓final body weight and weight of mesenteric adipose tissue; |
Casein: 20% |
= weight of perirenal and epididymal adipose tissuel; ↓feed efficiency ratio; |
|
↓ gene expression PPAR-γ, FAS e ACC; |
|
↑ CPT-1α; |
|
Effects of onion extract (0.72%): |
|
↓ retroperitoneal adipose tissue and visceral fat; ↓ C/EBP-α; |
|
Effects of onion extract (0.36%): |
|
↑ gene expression UCP-1. |
Benítez et al. (2012)BENÍTEZ, V., MOLLÁ, E., MARTÍN-CABREJAS, M.A., AGUILERA, Y., LÓPEZ-ANDRÉU, F.J. and ESTEBAN, R.M., 2012. Onion (Allium cepa L.) by-products as source of dietary Wber: physicochemical properties and effect on serum lipid levels in high-fat fed rats. European Food Research and Technology, vol. 234, no. 4, pp. 617-625. http://dx.doi.org/10.1007/s00217-012-1674-2. http://dx.doi.org/10.1007/s00217-012-167...
|
Wistar |
Female; 6 weeks |
Glucose: 189g; Casein: 200g; butter: 370g; Cholesterol: 45g |
4 weeks |
- Allium cepa L.;
|
4 weeks |
10% |
Effects of onion bagasse on the high fat diet: |
14/20 |
- The onions were milled to obtain a “bagasse” added to the diet. |
↓ body weight and food efficiency; |
↑food consumption; |
= weight of organs such as heart, kidney, intestine and spleen; all animals pallid colored liver and bigger livers; |
↓ total cholesterol and TG; |
↓ pH cecal content and fecal weight; |
↑ HDL-C. |
Lee et al. (2012)LEE, S.-M., MOON, J., DO, H.J., CHUNG, J.H., LEE, K.H., CHA, Y.J. and SHIN, M.J., 2012. Onion peel extract increases hepatic low-density lipoprotein receptor and ATP-binding cassette transporter A1 messenger RNA expressions in Sprague-Dawley rats fed a high-fat diet. Nutrition Research (New York, N.Y.), vol. 32, no. 3, pp. 210-217. http://dx.doi.org/10.1016/j.nutres.2012.01.004. PMid:22464808. http://dx.doi.org/10.1016/j.nutres.2012....
|
Sprague ‐ Dawley |
Male; 3 weeks |
Fat: 33%; |
8 weeks |
- No informed; |
8 weeks |
0.20% |
↑ LDLR, SREBP-2, HMG-CoAR and staeroyl - coA desaturase 1 gene expression in liver; ↓ apolipoprotein A1; |
out/20 |
Sucrose: 10% |
- Onion peel extracts extracted with 60% aqueous ethanol solution (50 ° C, 3 hours). |
↑ gene expression PPARγ2 and ATP-binding cassette subfamily G member 1 (ABDG1); |
Casein: 20% |
= body weight; = gene expression LXRα; |
|
↑ food efficiency; ↓ food consumption; |
Hamauzu et al. (2011)HAMAUZU, Y., NOSAKA, T., ITO, F., SUZUKI, T., TORISU, S., HASHIDA, M., FUKUZAWA, A., OHGUCHI, M. and YAMANAKA, S., 2011. Physicochemical characteristics of rapidly dried onion powder and its anti-atherogenic effect on rats fed high-fat diet. Food Chemistry, vol. 129, no. 3, pp. 810-815. http://dx.doi.org/10.1016/j.foodchem.2011.05.027. PMid:25212303. http://dx.doi.org/10.1016/j.foodchem.201...
|
Wistar |
Male; 9 weeks |
Fat: 5.1%; |
18 weeks |
- Allium cepa L.;
|
18 weeks |
5% |
= body weight; |
12/20 |
Protein: 22.2% |
- The powder was prepared from the external layer of the onion. |
↓ modulus of elasticity of rat aorta; |
|
↓ atherogenic index; |
|
= TG, total cholesterol and HDL-C. |
Kim et al. (2012)KIM, O.Y., LEE, S.-M., DO, H., MOON, J.W., LEE, K.H., CHA, Y.J. and SHIN, M.J., 2012. Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats. Phytotherapy Research, vol. 26, no. 3, pp. 432-437. http://dx.doi.org/10.1002/ptr.3570. PMid:21833991. http://dx.doi.org/10.1002/ptr.3570...
|
Sprague ‐ Dawley |
Male; 3 weeks |
Sucrose: 10%; |
8 weeks |
- No informed; |
8 weeks |
0.20% |
↓ food consumption; ↑ food efficiency index; |
dez/20 |
Casein: 20%; Cholesterol: 1% |
- Onion peel extracts extracted with 60% aqueous ethanol solution. |
= body weight; = weight of perirenal and epididymal adipose tissue; |
Corn oil: 6% |
= liver enzymes, blood urea nitrogen and Creatinine; = IL-6 gene expression; |
Lard: 10% |
↑ adiponectin and PPAR2γ gene expression in mesenteric fat; ↓ weight of mesenteric fat; |