Anti-diarrheic
|
Peel |
Methanolic extract |
Flavonoids and phenolic compounds |
10 mg/mL |
Heat-stable enterotoxins inhibition. |
Lescano et al. (2016)LESCANO, C.H., OLIVEIRA, I.P., ZAMINELLI, T., BALDIVIA, D.S., SILVA, L.R., NAPOLITANO, M., SILVÉRIO, C.B.M., LINCOPAN, N. and SANJINEZ-ARGANDOÑA, E.J., 2016. Campomanesia adamantium peel extract in antidiarrheal activity: the ability of inhibition of heat-stable enterotoxin by poliphenols. PLoS One, vol. 11, no. 10, e0165208. http://dx.doi.org/10.1371/journal.pone.0165208. PMid:27764241. http://dx.doi.org/10.1371/journal.pone.0...
|
Antibiotic
|
Leaf |
Essential oil (EO) |
Limonene, α-pinene and β-pinene (flowering stage); bicyclogermacrene, globulol, germacrene D and β-caryophyllene (fruit-bearing and vegetative stages) |
MIC ranging from 2 to 26 µg/mL |
Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans growth inhibition. |
Coutinho et al. (2009)COUTINHO, I.D., CARDOSO, C.A.L., RÉ-POPPI, N., MELO, A.M., VIEIRA, M.C., HONDA, N.K. and COELHO, R.G., 2009. Gas chromatography-mass spectrometry (GC-MS) and evaluation of antioxidant and antimicrobial activities of essential oil of Campomanesia adamantium O. Berg (Guavira). Brazilian Journal of Pharmaceutical Sciences, vol. 45, no. 4, pp. 767-776. http://dx.doi.org/10.1590/S1984-82502009000400022. http://dx.doi.org/10.1590/S1984-82502009...
|
Fruit |
Ethyl acetate extracts and their fractions |
5,7-dihydroxy-6,8-di-C-methyl-flavanone and 2’,4’-dihydroxy-3’,5’-dimethyl-6’-methoxy-chalcone |
MIC ranging from 62.5 to 7.8 µg/mL |
Anti-Mycobaterium tuberculosis property. |
Pavan et al. (2009)PAVAN, F.R., LEITE, C.Q.F., COELHO, R.G., COUTINHO, I.D., HONDA, N.K., CARDOSO, C.A.L., VILEGAS, W., LEITE, S.R.A. and SATO, D.N., 2009. Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quimica Nova, vol. 32, no. 5, pp. 1222-1226. http://dx.doi.org/10.1590/S0100-40422009000500026. http://dx.doi.org/10.1590/S0100-40422009...
|
Fruit |
Hexane extract and its fractions |
α-pinene, spathulenol, β-eudesmol, γ-cadinene and γ-muurolene |
MIC ranging from 5 to 20 µg/mL |
Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella setubal, Saccharomyces cerevisiae and Candida albicans growth inhibition. |
Cardoso et al. (2010)CARDOSO, C.A.L., SALMAZZO, G.R., HONDA, N.K., PRATES, C.B., VIEIRA, M.C. and COELHO, R.G., 2010. Antimicrobial activity of the extracts and fractions of hexanic fruits of Campomanesia Species (Myrtaceae). Journal of Medicinal Food, vol. 13, no. 5, pp. 1273-1276. http://dx.doi.org/10.1089/jmf.2009.0047. PMid:20828322. http://dx.doi.org/10.1089/jmf.2009.0047...
|
Leaf |
Essential oil (EO) |
Spathulenol (19.27%), germacrene-B (18.27%) and β-caryophyllene oxide (12.37%) |
MIC ranging from 100 to 400 µg/mL |
Moderate antibacterial inhibition of multiple Streptococcus strains (gram-positive) and Bacteroides fragilis (gram-negative). |
Oliveira et al. (2016)OLIVEIRA, J.D., ALVES, C.C.F., MIRANDA, M.L.D., MARTINS, C.H.G., SILVA, T.S., AMBROSIO, M.A.L.V., ALVES, J.M. and SILVA, J.P., 2016. Rendimento, composição química e atividades antimicrobiana e antioxidante do óleo essencial de folhas de Campomanesia adamantium submetidas a diferentes métodos de secagem. Revista Brasileira de Plantas Medicinais, vol. 18, no. 2, pp. 502-510. http://dx.doi.org/10.1590/1983-084X/15_206. http://dx.doi.org/10.1590/1983-084X/15_2...
|
Anti-inflammatory
|
Leaf |
Ethyl acetate (EA) and aqueous extracts and EA fractions |
Myricitrin, myricetin and quercetin from EA extract (flavonoids). Components from aqueous extract were not cited. |
In vivo experiments: 125 mg/kg (AE) and 250 mg/kg (aqueous extract). Inhibition of NO: 320 µg/mL (AE), 6.25 µM (Myricitrin and Myricetin). Inhibition of TNF-α: 320 µg/mL (AE), 100 µM (Myricitrin) and 25 µM (Myricetin). IL-10 production: 160 µg/mL (AE), 25 µM (Myricitrin) and 50 µM (Myricetin). |
Inhibition of carrageenan-induced paw oedema and reduction of time to licking of formalin method and the number of writhes in mice. In vitro inhibition of NO and TNF-α production by macrophages and increased production of IL-10 by macrophages. |
Ferreira et al. (2013)FERREIRA, L.C., GRABE-GUIMARÃES, A., PAULA, C.A., MICHEL, M.C.P., GUIMARÃES, R.G., REZENDE, S.A., SOUZA FILHO, J.D. and SAÚDE-GUIMARÃES, D.A., 2013. Anti-inflammatory and antinociceptive activities of Campomanesia adamantium. Journal of Ethnopharmacology, vol. 145, no. 1, pp. 100-108. http://dx.doi.org/10.1016/j.jep.2012.10.037. PMid:23123269. http://dx.doi.org/10.1016/j.jep.2012.10....
|
Peel |
Methanolic extract |
Flavonoids and phenolic compounds |
1 mg/mL |
In vitro COX-1 and COX-2 inhibition. |
Lescano et al. (2016)LESCANO, C.H., OLIVEIRA, I.P., ZAMINELLI, T., BALDIVIA, D.S., SILVA, L.R., NAPOLITANO, M., SILVÉRIO, C.B.M., LINCOPAN, N. and SANJINEZ-ARGANDOÑA, E.J., 2016. Campomanesia adamantium peel extract in antidiarrheal activity: the ability of inhibition of heat-stable enterotoxin by poliphenols. PLoS One, vol. 11, no. 10, e0165208. http://dx.doi.org/10.1371/journal.pone.0165208. PMid:27764241. http://dx.doi.org/10.1371/journal.pone.0...
|
Bark |
Hydroethanolic extract |
Aqueous fraction: myricitrin. Methanolic fraction: quercetin, myricetin, 5,7-dihydroxy-6-methylflavanone, 5,7-dihydroxy-8-mthylflavanone and 2’,4’-dihydroxy-6’-methoxychalcone. Ethyl acetate fraction: 7-hydroxy-5-methoxy-6-methylflavanone, 5,7-dihydroxy-6,8-dimthylflavanone and 2’,4’-dihydroxy-3’,5’-dimethyl-6’-methoxychalcone. |
100 mg/kg (inhibition of leukocyte migration) and 300 mg/kg (inhibition of protein leakage). |
Inhibition of leukocyte migration and protein leakage. |
Souza et al. (2017)SOUZA, J.C., PICCINELLI, A.C., AQUINO, D.F.S., SOUZA, V.V., SCHMITZ, W.O., TRAESEL, G.K., CARDOSO, C.A.L., KASSUYA, C.A.L. and ARENA, A.C., 2017. Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks. Nutritional Neuroscience, vol. 20, no. 1, pp. 23-31. http://dx.doi.org/10.1179/1476830514Y.0000000145. PMid:25116451. http://dx.doi.org/10.1179/1476830514Y.00...
|
Seed and Peel |
Essential oils (EO) |
Seed EO: limonene (20.89%) and β-pinene (11.48%). Peel EO: limonene (13.07%) and thujopsene (6.96%). |
100 mg/kg for both EO tested. |
Inhibition of leukocyte migration, paw oedema and 1st and 2nd phases of formalin-induced nociception (inflammatory and neurogenic pain). |
Zuntini Viscardi et al. (2017)ZUNTINI VISCARDI, D., ARRIGO, J., CORREIA, C.A., KASSUYA, C.A., CARDOSO, C.A., MALDONADE, I.R. and ARGANDOÑA, E.J., 2017. Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents. PLoS One, vol. 12, no. 2, e0157107. http://dx.doi.org/10.1371/journal.pone.0157107. PMid:28222179. http://dx.doi.org/10.1371/journal.pone.0...
|
Peel |
Methanolic extract and isolated flavonoids (quercetin and myricetin) |
5,7-dihydroxy-6-methylflavanone, 5,7-dihydroxy-8-methylflavanone, 2′,4′dihydroxy 6′-methoxychalcone, 7-hydroxy-5-methoxy-6-methylflavavone, 5,7-dihydroxy-6,8-dimethylflavanone, quercetin, myricetin and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone |
Peel Extract: from 0.25 to 10 mg/mL. Quercetin and myricetin: 10 µM. |
Inhibition of COX-1 and platelet aggregation in vitro. |
Lescano et al. (2018)LESCANO, C.H., LIMA, F.F., MENDES-SILVÉRIO, C.B. and JUSTO, A.F.O., 2018. Effect of polyphenols from Campomanesia adamantium on platelet aggregation and inhibition of cyclooxygenases: Molecular docking and In Vitro analysis. Frontiers in Pharmacology, vol. 9, pp. 617. http://dx.doi.org/10.3389/fphar.2018.00617. PMid:29946259. http://dx.doi.org/10.3389/fphar.2018.006...
|
Peel and Pulp |
Dichloromethane extracts and isolated dimethylchalcone (DMC) from pulp extract. |
Dichloromethane pulp extract: 7-hydroxy-5-methoxy-6-C-methylflavanone, 5,7-dihydroxy-6,8-C-methylflavanone, 5,7-dihydroxy-6,8-C-methylflavanone, 4’,6’-dihydroxy-3’,5’-dimethyl-2’-methoxychalcone, 4’,6’-dihydroxy-3’-methyl-2’-methoxychalcone, champanone C and champanone D. |
GI50 of pulp extract: 16.17 µg/mL. 50% inhibition of NO release: 25 µg/mL. |
Inhibition of NO release of murine intraperitoneal macrophages co-cultured with melanoma murine cells (B16F10). |
Silva et al. (2018)SILVA, M.C.B.L., BOGO, D., ALEXANDRINO, C.A.F., PERDOMO, R.T., FIGUEIREDO, P.O., DO PRADO, P.R., GARCEZ, F.R., KADRI, M.C.T., XIMENES, T.V.N., GUIMARÃES, R.C.A., SARMENTO, U.C. and MACEDO, M.L.R., 2018. Antiproliferative activity of extracts of Campomanesia adamantium (Cambess.) O. Berg and isolated compound dimethylchalcone against B16-F10 murine melanoma. Journal of Medicinal Food, vol. 21, no. 10, pp. 1024-1034. http://dx.doi.org/10.1089/jmf.2018.0001. PMid:29715052. http://dx.doi.org/10.1089/jmf.2018.0001...
|
Anti-oxidant
|
Leaf |
Methanolic extract |
7-hydroxy-5-methoxy-flavanone, 7-hydroxy-5-methoxy-6-methylflavanone, 5,7-dihydroxy-6-methylflavanone, 5,7-dihydroxy-8-methylflavanone, 2’,4’-dihydroxy-6’-methoxychalcone, 5,7-dihydroxy-6,8-dimethylflavanone, 2’,4’-dihydroxy-6’-methoxy-5’-methylchalcone, 2’,4’-dihydroxy-6’-methoxy-3’-methylchalcone and 2’,4’-dihydroxy-6’-methoxy-3’,5’- dimethylchalcone. |
Ranging from 80 to 480 µg/mL depending on the region of leaves collection (antioxidant activity). Ranging from 144-160 µg/mL depending on the region of leaves collection (lipid peroxidation inhibition). |
High antioxidant activity (DPPH) and lipid peroxidation inhibition. |
Coutinho et al. (2008)COUTINHO, I.D., COELHO, R.G., KATAOBA, V.M.F., HONDA, N.K., SILVA, J.R.M., VILEGAS, W. and CARDOSO, C.A.L., 2008. Determination of phenolic compounds and evaluation of antioxidant capacity of Campomanesia adamantium leaves. Eclética Química, vol. 33, no. 4, pp. 53-60. http://dx.doi.org/10.26850/1678-4618eqj.v33.4.2008.p53-60. http://dx.doi.org/10.26850/1678-4618eqj....
|
Root |
Aqueous extract |
Identification of gallic acid and ellagic acid. |
Antioxidant capacity (DPPH): starting with 37.3 µg/mL and reaching the maximum activity with 250 µg/mL. Protection against induced hemolysis: from 75 to 125 µg/mL. |
High antioxidant activity (DPPH) and lipid peroxidation inhibition. |
Espindola et al. (2016)ESPINDOLA, P.P.T., ROCHA, P.S., CAROLLO, C.A., SCHMITZ, W.O., PEREIRA, Z.V., VIEIRA, M.C. and SANTOS, E.L., 2016. Antioxidant and antihyperlipidemic effects of Campomanesia adamantium O. Berg root. Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 7910340. http://dx.doi.org/10.1155/2016/7910340. PMid:27493705. http://dx.doi.org/10.1155/2016/7910340...
|
Leaf |
Ethanolic extract and fractions |
Isoquercitrin, quercitrin, myricetin, quercetin, 2’,4’-dihydroxy-6’-methoxychalcone, 2’,4’-dihydroxy-5’-methyl-6’-methoxychalcone and 2’,4’-dihydroxy-3’,5’-dimethyl-6’-methoxychalcone. |
DPPH: from 7.77 to 13.35 µg/mL. ORAC: from 2648 to 3502 µM of TE/g of extract. |
High antioxidant activity (DPPH and ORAC) |
Pascoal et al. (2011)PASCOAL, A.C.R.F., EHRENFRIED, C.A., EBERLIN, M.N., STEFANELLO, M.E.A. and SALVADOR, M.J., 2011. Free radical scavenging activity, determination of phenolic compounds and HPLC-DAD/ESI-MS profile of Campomanesia adamantium leaves. Natural Product Communications, vol. 6, no. 7, pp. 969-972. http://dx.doi.org/10.1177/1934578X1100600711. PMid:21834235. http://dx.doi.org/10.1177/1934578X110060...
|
Antitumoral
|
Leaf and Fruits |
Ethanolic extract and isolated chalcone (cardamonin) |
Quantification of cardamonin in leaves extract (87.74 µg/mg) and fruits extract (5.4 µg/mg) through UPLC-MS methodology. Isolated chalcone: 2E-1-2,4-dihydroxy-6-methoxyphenyl-3-penylprop-2-en-1-one (cardamonin). |
GI50: 3.20 µg/Ml (leaf extract), 14.25 µg/mL (fruits extract) and 11.35 µg/mL (isolated cardamonin). Downregulation of NF-Kβ and apoptosis induction: 20 µg/mL. |
Antiproliferative activity on prostate cancer cells by downregulating NF-Kβ and apoptosis induction |
Pascoal et al. (2014)PASCOAL, A.C., EHRENFRIED, C.A., LOPEZ, B.G., ARAUJO, T.M., PASCOAL, V.D., GILIOLI, R., ANHÊ, G.F., RUIZ, A.L., CARVALHO, J.E., STEFANELLO, M.E. and SALVADOR, M.J., 2014. Antiproliferative activity and induction of apoptosis in PC-3 cells by the chalcone cardamonin from Campomanesia adamantium (Myrtaceae) in a bioactivity-guided study. Molecules, vol. 19, no. 2, pp. 1843-1855. http://dx.doi.org/10.3390/molecules19021843. PMid:24514747. http://dx.doi.org/10.3390/molecules19021...
|
Root and Leaf |
Aqueous extract |
Root extract: di-hexoside/quinic acid, ellagic acid O-pentoside, ellagic acid, O-methyl ellagic acid O-hexoside, ellagic acid O-deoxyhexoside and O-methyl ellagic acid sulfate. Leaves extract: di-hexoside/quinic acid, myricetin O-pentoside, myricetin O-deoxyhexoside, quercetin O-pentoside and myricetin O-(O-galloyl)-pentoside. |
IC50: 80 µg/mL (roots extract) and 40 µg/mL (leaves extract). |
Apoptotic death of leukemic cells by decreasing the mitochondrial membrane potential, increasing the activation of caspase 9 and 3, and intracellular Ca2+ levels. |
Campos et al. (2017)CAMPOS, J.F., ESPINDOLA, P.P.T., TORQUATO, H.F.V., VITAL, W.D., JUSTO, G.Z., SILVA, D.B., CAROLLO, C.A., PICOLI SOUZA, K., PAREDES-GAMERO, E.J. and SANTOS, E.L., 2017. Leaf and root extracts from Campomanesia adamantium (Myrtaceae) promote apoptotic death of leukemic cells via activation of intracellular calcium and caspase-3. Frontiers in Pharmacology, vol. 8, pp. 466. http://dx.doi.org/10.3389/fphar.2017.00466. PMid:28855870. http://dx.doi.org/10.3389/fphar.2017.004...
|
Peel and Pulp |
Dichloromethane extracts and isolated dimethylchalcone (DMC) from pulp extract. |
Dichloromethane pulp extract: 7-hydroxy-5-methoxy-6-C-methylflavanone, 5,7-dihydroxy-6,8-C-methylflavanone, 5,7-dihydroxy-6,8-C-methylflavanone, 4’,6’-dihydroxy-3’,5’-dimethyl-2’-methoxychalcone, 4’,6’-dihydroxy-3’-methyl-2’-methoxychalcone, champanone C and champanone D. |
GI50 of pulp extract: 16.17 µg/mL. Caspase-3 activation: 25 µg/mL. |
DMC (isolated from pulp extract) had antiproliferative activity on murine melanoma cells by inducing apoptosis (caspase-3 activation). |
Silva et al. (2018)SILVA, M.C.B.L., BOGO, D., ALEXANDRINO, C.A.F., PERDOMO, R.T., FIGUEIREDO, P.O., DO PRADO, P.R., GARCEZ, F.R., KADRI, M.C.T., XIMENES, T.V.N., GUIMARÃES, R.C.A., SARMENTO, U.C. and MACEDO, M.L.R., 2018. Antiproliferative activity of extracts of Campomanesia adamantium (Cambess.) O. Berg and isolated compound dimethylchalcone against B16-F10 murine melanoma. Journal of Medicinal Food, vol. 21, no. 10, pp. 1024-1034. http://dx.doi.org/10.1089/jmf.2018.0001. PMid:29715052. http://dx.doi.org/10.1089/jmf.2018.0001...
|
Peel |
Hydroethanolic extract |
NS
|
5 mg/animal |
Absence of acute toxicity at 2000 mg/kg in vivo and inhibition of murine melanoma cells in vivo. |
Luiz et al. (2019)LUIZ, A.T., SILVA, M.C.B.L., ALEXANDRINO, C.A.F., GUIMARÃES, R.C.A., SILVA, V.J., MATTOS, G.F., PERDOMO, R.T., SALOMÃO, E.A. and BOGO, D., 2019. Inhibition of tumoral growth by hydroethanolic extract of peel from Campomanesia adamantium (Cambess) O. Berg in melanoma. International Journal of Developmental Research, vol. 9, pp. 25593-25598.
|
Leaf |
Essential oils (EO) |
Spathulenol (19.27%), germacrene-B (18.27%) and β-caryophyllene oxide (12.37%) |
IC50 ranging from 77.2 to 80.5 µg/mL |
Antiproliferative activity against breast, cervical and glioblastoma cell lines and satisfactory selectivity index when compared with lung fibroblast cell line. |
Alves et al. (2020)ALVES, C.C.F., OLIVEIRA, J.D., ESTEVAM, E.B.B., XAVIER, M.N., NICOLELLA, H.D., FURTADO, R.A., TAVARES, D.C. and MIRANDA, M.L.D., 2020. Antiproliferative activity of essential oils from three plants of Brazilian Cerrado: Campomanesia adamantium (Myrtaceae), Protium ovatum (Burseraceae) and Cardiopetalum calophyllum (Annonaceae). Brazilian Journal of Biology = Revista Brasileira de Biologia, vol. 80, no. 2, pp. 290-294. http://dx.doi.org/10.1590/1519-6984.192643. PMid:31017239. http://dx.doi.org/10.1590/1519-6984.1926...
|
Anti-hyperalgesic
|
Bark |
Hydroethanolic extract and its fractions |
Aqueous fraction: myricitrin. Methanolic fraction: quercetin, myricetin, 5,7-dihydroxy-6-methylflavanone, 5,7-dihydroxy-8-methylflavanone and 2’,4’-dihydroxy-6’-methoxychlacone. Ethyl acetate fraction: 7-hydroxy-5-methoxy-6-methylflavanone, 5,7-dihydroxy-6,8-dimethylflavanone and 2’,4’-dihydroxy-3’,5’-dinethyl-6’-methoxychalcone. |
100 mg/kg |
Inhibition of SNI-induced mechanical hyperalgesia. |
Souza et al. (2017)SOUZA, J.C., PICCINELLI, A.C., AQUINO, D.F.S., SOUZA, V.V., SCHMITZ, W.O., TRAESEL, G.K., CARDOSO, C.A.L., KASSUYA, C.A.L. and ARENA, A.C., 2017. Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks. Nutritional Neuroscience, vol. 20, no. 1, pp. 23-31. http://dx.doi.org/10.1179/1476830514Y.0000000145. PMid:25116451. http://dx.doi.org/10.1179/1476830514Y.00...
|
Antidepressant
|
Bark |
Hydroethanolic extract and its fractions |
Aqueous fraction: myricitrin. Methanolic fraction: quercetin, myricetin, 5,7-dihydroxy-6-methylflavanone, 5,7-dihydroxy-8-methylflavanone and 2’,4’-dihydroxy-6’-methoxychlacone. Ethyl acetate fraction: 7-hydroxy-5-methoxy-6-methylflavanone, 5,7-dihydroxy-6,8-dimethylflavanone and 2’,4’-dihydroxy-3’,5’-dinethyl-6’-methoxychalcone. |
100 mg/kg |
Decreased immobility behavior time in the forced swim test. |
Souza et al. (2017)SOUZA, J.C., PICCINELLI, A.C., AQUINO, D.F.S., SOUZA, V.V., SCHMITZ, W.O., TRAESEL, G.K., CARDOSO, C.A.L., KASSUYA, C.A.L. and ARENA, A.C., 2017. Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks. Nutritional Neuroscience, vol. 20, no. 1, pp. 23-31. http://dx.doi.org/10.1179/1476830514Y.0000000145. PMid:25116451. http://dx.doi.org/10.1179/1476830514Y.00...
|
Antihyperlipidemic
|
Root |
Aqueous extract |
Identification of gallic acid and ellagic acid. |
Protection against lipid peroxidation (MDA dosage): starting with 50 µg/mL with a maximum effect with 500 µg/mL. In vivo serum MDA dosage: 200 mg/kg. |
Decreased production of MDA in human erythrocytes in vitro and serum MDA in vivo. |
Espindola et al. (2016)ESPINDOLA, P.P.T., ROCHA, P.S., CAROLLO, C.A., SCHMITZ, W.O., PEREIRA, Z.V., VIEIRA, M.C. and SANTOS, E.L., 2016. Antioxidant and antihyperlipidemic effects of Campomanesia adamantium O. Berg root. Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 7910340. http://dx.doi.org/10.1155/2016/7910340. PMid:27493705. http://dx.doi.org/10.1155/2016/7910340...
|
Hepatoprotection
|
Pulp and Peel/Seed |
Hydroethanolic extract |
Presence of flavonoids in both extracts. |
Hepatoprotection in vitro (CCl4-induced): 800 µg/mL. Hepatoprotection in vivo: 1000 µg/mL. |
Hepatoprotection in vitro (HepG2 cells) against CCl4-induced toxicity preventing apoptosis and maintenance of AST and ALT levels similar to control group in vivo. |
Oliveira Fernandes et al. (2015)OLIVEIRA FERNANDES, T., ÁVILA, R.I., MOURA, S.S., ALMEIDA RIBEIRO, G., NAVES, M.M.V. and VALADARES, M.C., 2015. Campomanesia adamantium (Myrtaceae) fruits protect HEPG2 cells against carbon tetrachloride-induced toxicity. Toxicology Reports, vol. 2, pp. 184-193. http://dx.doi.org/10.1016/j.toxrep.2014.11.018. http://dx.doi.org/10.1016/j.toxrep.2014....
|
Peel and Seed (industrial residue) |
Industrial residue flour as supplementation to hypercaloric diet in vivo. |
Fibers and phenolic compounds. |
Fiber content: 57.1 ± 1.64 g/100 g GF Total phenolic content: 7,391.09 mg AGE/100 g GF Antioxidant capacity: 2.22 (IC50) and 155.68 µmol/TE.g-1 (ORAC). Steatosis attenuation: 2% GF supplementation (20 g/kg). |
High total fiber content, phenolic compounds and antioxidant capacity. Steatosis attenuation compared to control group in vivo. |
Loubet Filho et al. (2020) |
Photoprotection
|
Leaf |
Dry ethanolic crude extract |
Myricitrin, myricetin, cardamonin, gallic acid and strictane-3,22-diol valonic acid. |
Formula containing 4% of C. adamantium extract with 4% C. xanthocarpa extract. |
Extracts presented absorption at UVA and UVB regions and the best formulation was C. adamantium in association with SSPF and C. xanthocarpa extract with a SPF > 6. |
Catelan et al. (2019)CATELAN, T.B.S., GAIOLA, L., DUARTE, B.F. and CARDOSO, C.A.L., 2019. Evaluation of in vitro photoprotective potential of ethanolic extracts of four species of the genus Campomanesia. Journal of Photochemistry and Photobiology. B, Biology, vol. 197, e111500. http://dx.doi.org/10.1016/j.jphotobiol.2019.04.009. PMid:31200215. http://dx.doi.org/10.1016/j.jphotobiol.2...
|