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Article - Human and Animal Health • Braz. arch. biol. technol. 65 • 2022 • https://doi.org/10.1590/1678-4324-2022210260   copy

Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

Authorship SCIMAGO INSTITUTIONS RANKINGS

HIGHLIGHTS

  • Exploring the role of TGFβ and its associate genes in the pathogenetic mechanism of EMT in renal fibrosis.

  • Possible immunohistochemical markers (Pancytokeratin, SMA and Vimentin) to identify the process of EMT.

  • Availability of various EMT related anti-fibrotic therapy with emphasis on stem cell therapy.

Abstract

Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies.

The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.

Keywords:
renal fibrosis; myofibroblast; epithelial-mesenchymal transition; chronic kidney disease; anti-fibrotic therapy.

Instituto de Tecnologia do Paraná - Tecpar Rua Prof. Algacyr Munhoz Mader, 3775 - CIC, 81350-010 Curitiba PR Brazil, Tel.: +55 41 3316-3052/3054, Fax: +55 41 3346-2872 - Curitiba - PR - Brazil
E-mail: babt@tecpar.br
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