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Article - Biological and Applied Sciences • Braz. arch. biol. technol. 65 • 2022 • https://doi.org/10.1590/1678-4324-2022210114   copy

Influence of Lycium barbarum Extract Intake on Oxidative Stress in Wistar Rats

Authorship SCIMAGO INSTITUTIONS RANKINGS

HIGHLIGHTS

  • L. barbarum promote the increase in catalase enzyme activity in the liver of rats.

  • L. barbarum increase mRNA expression of catalase enzyme in the liver of rats.

  • L. barbarum extract produced a significant oxidation decrease in the liver of rats.

  • L. barbarum extract has a significant amount of bioactive compounds.

Abstract:

This study aimed to analyze the effects of Goji Berry extract (GB, Lycium barbarum) gavage administration on liver tissue oxidative stress in Wistar rats as well as to identify and quantify the content of the major bioactive compounds of the fruit. Four diets were applied: SW - standard diet + water; SG - standard diet + Goji Berry extract (125 mg/kg of animal); PW - palatable diet + water; PG - palatable diet + Goji Berry extract (125 mg/kg of animal). Results showed a significant increase in catalase enzyme activity in the liver of rats treated with GB and also in those intaking the palatable diet without GB when compared to the SW group. An increased mRNA expression of this enzyme in the same tissue and groups was also verified. Regarding lipid peroxidation, the GB extract produced a significant decrease in the oxidation state in the SG and PG groups. The results also showed a significant amount of bioactive compounds in GB extract.

Keywords:
Goji Berry; Oxidative damage; Lipid peroxidation; Antioxidant enzymes

GRAPHICAL ABSTRACT:


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