The Relationship between Functional and Evolutionary Correlations of Enzyme Reactions in Metabolic Network Evolution

HIGHLIGHTS

A method of computing the correlation connection network is first proposed.

A concept of the mean functional concentration ratios of the enzyme reactions is proposed.

The functional concentration ratio and the evolutionary correlation are related.

Abstract

The evolution of species is inevitably accompanied by the evolution of metabolic networks to adapt to different environments. The metabolic networks of different species were collected from the Kyoto Encyclopedia of Genes and Genomes (KEGG) website, and some enzyme reactions with the highest occurrence frequency in all species were found and are reported in this paper. The correlation coefficients of whether the enzyme reactions appear in all species were calculated, and the corresponding evolutionary correlation connection networks were calculated according to different correlation coefficient thresholds. These studies show that, as the evolutionary correlation of enzyme reactions increases, the weighted average of the mean functional concentration ratios of the enzyme reactions also increases, indicating that the functional concentration ratio of enzyme reactions has a certain correlation with the evolutionary correlation. The work presented in this paper enhances our understanding of the characteristics and general rules of metabolic network evolution.

Keywords:
metabolic network; pan-metabolic network; metabolic network evolution; connected component; enzyme reaction