In Vitro Enzyme Inhibitory Activity of Ten Ferulago W. Koch Species Growing in Turkey

Akkol, Esra Küpeli; Günbatan, Tuğba; Gürbüz, İlhan; Duman, Hayri; Kılıç, Ceyda Sibel; İlhan, Mert

doi:10.1590/1678-4324-2022210207

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Article - Human and Animal Health • Braz. arch. biol. technol. 65 • 2022 • https://doi.org/10.1590/1678-4324-2022210207 copy

In Vitro Enzyme Inhibitory Activity of Ten Ferulago W. Koch Species Growing in Turkey

Authorship SCIMAGO INSTITUTIONS RANKINGS

HIGHLIGHTS

Ethanol extract of F. mascrosciadia significantly inhibits collagenase and elastase.
Ethanol extract of F. syriaca significantly inhibits collagenase and elastase.
Other studied Ferulago species do not show activity on collagenase and elastase enzymes.

Abstract

Ferulago species are traditionally used for the treatment of skin diseases, bronchitis, and depression, to increase body strength, as an immunostimulant, aphrodisiac and sedative in Anatolia. In this study, hyaluronidase, collagenase and elastase inhibitory potential relevant to wound healing activities of ethanol extracts from the roots of ten Ferulago species [F. cassia Boiss., F. humilis Boiss., F. isaurica Peşmen, F. longistylis Boiss., F. mascrosciadia Boiss. & Balansa, F. sandrasica Pesmen & Quézel, F. setifolia K. Koch., F. silaifolia (Boiss.) Boiss., F. trojana Akalın & Pimenov formerly known as F. sylvatica (Besser) Rchb. and F. syriaca Boiss.] were investigated. Ethanol extracts of F. mascrosciadia and F. syriaca were the most active ones against collagenase and elastase, respectively. In vitro wound healing activity of ten Ferulago species is reported for the first time in the current study.

Keywords:
Ferulago; Collagenase; Elastase; Hyaluronidase; Wound

Plant name	Collection site	Herbarium number	Extract yield (w/w, %)
Ferulago cassia Boiss.	Konya, Beyşehir, at 1^st km of Tınaztepe-Bozkır old road, serpentine areas, Pinus nigra forest opening, 1555 m, 20/6/2016, (37° 13.785’N / 31° 5.537’W)	AEF 28775	19.45
Ferulago humilis Boiss.	Muğla, Milas, North of İkizköy, under Pinus brutia openings, 250 m, 9/6/2016 (35S 577097 / 4114855)	AEF 28773	17.66
Ferulago isaurica Peşmen	Antalya-Alanya, between Durbannaz-Banlıca, under Pinus brutia forest, calcerous rocks, 837 m, 21/6/2016, (36° 39.095’N / 32° 7.497’W)	AEF 28778	20.45
Ferulago longistylis Boiss.	Erzincan-Refahiye road, Sakaltutan locality, high mountain steppe, 2030 m, 13/7/2016, (39° 52.885’N / 39° 9.292’W)	AEF 28777	24.02
Ferulago mascrosciadia Boiss. & Balansa	Balıkesir, Bigadiç, North of Düğüncüler village, under Quercus trees and in Cistus laurifolius openings, 8/6/2016 (39° 16.333’N / 28° 32.141’E)	AEF28776	22.35
Ferulago sandrasica Pesmen & Quézel	Denizli, Beyağaç, Beyağaç-Köyceğiz road, at Kartal Lake intersection, 1390m, 9/6/2016, (37° 7.674’N / 28° 50.267’E)	AEF 28772	19.48
Ferulago setifolia K. Koch	Erzincan, Üzümlü district, Karakaya Town, Karakaya Town, between Karakaya-Tekçam Highland, high mountain steppe, 2047 m, 13/7/2016, (39° 42.127’N / 39° 45.874’W)	AEF 28770	16.37
Ferulago silaifolia (Boiss.) Boiss.	Bursa, Uludağ road, 10 km to the National Park, under Castanea sativa and Pinus nigra forest, 837 m 7/6/2016 (40° 8.69’K / 29° 1.019’D)	AEF 28771	16.02
Ferulago syriaca Boiss.	Hatay, Harbiye-Şenköy road, maquis openings, 452 m 22/6/2016452 m (36° 7.194’N / 36° 9.988’W)	AEF 28779	16.37
Ferulago trojana Akalın & Pimenov	Çanakkale, Çan, Terzialan-Bayramiç road, 5. km, under the oak forest, schistose soil, 365 m, 8/6/2016, (39° 55.928’K / 27° 0.544’D)	AEF 28774	18.84

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[1] *Correspondence: esrak@gazi.edu.tr; Tel.: +90 312 2023185 (E.K.A.)