Effects of calcium supplementation on markers of preeclampsia: randomized clinical trial

Pitilin, Erica de Brito; Bagatini, Margarete Dulce; Gasparin, Vanessa Aparecida; Oliveira, Patricia Pereira de; Lentsck, Maicon Henrique; Baratieri, Tatiane; Falavina, Larissa Pereira; Schirmer, Janine

doi:10.37689/acta-ape/2024AO00016222

Erica de Brito Pitilin

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade Federal da Fronteira Sul, Chapecó, SC, Brazil.

http://orcid.org/0000-0003-3950-2633

Margarete Dulce Bagatini

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade Federal da Fronteira Sul, Chapecó, SC, Brazil.

http://orcid.org/0000-0001-9263-4980

Vanessa Aparecida Gasparin

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil.

http://orcid.org/0000-0002-4266-3668

Patricia Pereira de Oliveira

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

http://orcid.org/0000-0002-1640-6887

Maicon Henrique Lentsck

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.

http://orcid.org/0000-0002-8912-8902

Tatiane Baratieri

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.

http://orcid.org/0000-0002-0270-6395

Larissa Pereira Falavina

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Universidade de São Paulo, São Paulo, SP, Brazil.

http://orcid.org/0000-0001-9158-6673

Janine Schirmer

collaborated with the design of the study

analysis and interpretation of data

writing of the article

relevant critical review of the intellectual content and approval of the final version to be published

Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

http://orcid.org/0000-0003-0783-2961

Corresponding author: Erica de Brito Pitilin E-mail: erica.pitilin@uffs.edu.br

Associate Editor (Peer review process): Kelly Pereira Coca (https://orcid.org/0000-0002-3604-852X) Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, SP, Brazil

Conflicts of interest: Although Schirmer J is the Editor-in-Chief of Acta Paulista de Enfermagem, she did not participate in the peer review process of the aforementioned article.

Variables	500mg calcium/day group (n=58)	1,500mg calcium/day group (n=58)	Placebo group (n=59)	p-value
	Mean (SD)	Mean (SD)	Mean (SD)
Age (years)	30.2 (5.1)	30.4 (5.1)	28.6 (4.7)	0.327
Education (years of study)	12.4 (5.5)	12.4 (4.6)	13.9 (5.3)	0.427
Gestational age (weeks)	26.9 (4.0)	26.3 (4.7)	28.2 (5.0)	0.299
Initial weight (Kg)	94.2 (17.3)	86.5 (16.3)	87.7 (17.9)	0.227
Initial BMI (Kg/m²)	35.7 (5.9)	32.6 (7.1)	32.7 (6.2)	0.161
Dietary calcium (g)	531.5 (315.7)	731.5 (477.0)	569.7 (310.1)	0.135
Initial SBP (mmHg)	131.6 (13.8)	131.5 (11.2)	127.8 (12.6)	0.416
Initial DBP (mmHg)	84.2 (9.3)	83.8 (13.2)	81.3 (8.9)	0.531
Platelets, mg/dl	236.380 (50.3)	238.436 (57.6)	262.144 (60.9)	0.105
Urea, mg/dl	16.2 (4.8)	19.2 (6.2)	17.1 (4.3)	0.098
Creatinine, mg/dl	76.4 (36.9)	82.9 (38.8)	79.8 (23.2)	0.932
Proteinuria, mg/dl	26.4 (32.5)	24.9 (37.1)	26.4 (32.2)	0.076
P/C ratio	0.2 (0.2)	0.2 (0.1)	0.1 (0.5)	0.302
Microalbuminuria	7.7 (6.3)	8.7 (2.7)	6.2 (3.0)	0.212
PTH, pg/ml	20.2 (19.0)	23.4 (12.2)	22.9 (10.2)	0.987
Ionized calcium, mg/dl	9.1 (0.2)	9.1 (0.2)	9.4(0.2)	0.832
After eight weeks	n (%)	n (%)	n (%)
Low adherence to treatment	4 (2.2)	14 (8)^#	3 (1.7)	0.026^#
Loss of follow-up	31 (17.7)	34 (19.4)	27 (15.4)	0.890

Factors	Intercept		Groups		Time		Group/Time
Parameters	F^§	p**	F^§	p**	F^§	p**	F^§	p**
SBP, mmHg	7.68	0.000	1.04	0.355	19.25	0.000	7.74	0.000
DBP, mmHg	8.91	0.000	1.84	0.160	25.56	0.000	8.64	0.000
Platelets, mg/dl	1.74	0.088	2.24	0.108	2.00	0.137	1.51	0.199
Urea, mg/dl	4.96	0.000	0.04	0.956	3.39	0.035	8.86	0.000
Creatinine, mg/dl	4.10	0.000	10.8	0.000	4.30	0.014	1.57	0.181
Proteinuria, mg/dl	10.8	0.000	18.7	0.000	18.0	0.000	6.0	0.000
P/C ratio	2.86	0.004	5.95	0.003	3.03	0.049	2.04	0.089
Microalbuminuria	2.80	0.005	8.50	0.000	1.98	0.139	0.87	0.481
PTH, pg/ml	2.08	0.037	2.01	0.135	3.81	0.023	2.09	0.008
Ionized calcium, mg/dl	6.31	0.000	3.01	0.051	19.23	0.000	5.84	0.000

[1] Corresponding author: Erica de Brito Pitilin E-mail: erica.pitilin@uffs.edu.br

Brasil

Brasil

Effects of calcium supplementation on markers of preeclampsia: randomized clinical trial

Abstract

Objective

Methods

Results

Conclusion