Abstract
Objective
To assess the effect of using mechanical ventilation with positive end-expiratory pressure (PEEP) on the renal function of patients admitted to the Intensive Care Unit (ICU).
Methods
This is a quantitative retrospective cohort study developed in the ICU of a public hospital in Brasília, Distrito Federal. The sample consisted of 52 medical records of patients admitted to the ICU from November 2016 to December 2018. Data collection was performed through a questionnaire with demographic, clinical and laboratory data. Patients were allocated in two groups: (1) PEEP ≤ 5 cmH2O, (2) PEEP > 5 cmH2O and < 10 cmH2O, and (3) PEEP ≥ 10 cmH2O.
Results
The mean age of patients was 59 years and 50% of them were over 63 years. It was found that 63.16% of patients who were on mechanical ventilation with positive end-expiratory pressure ≥ 10 cmH2O evolved in stage 1 (less severe acute kidney injury (AKI)) and 21.5% in stage 2 (moderate gravity). Even so, a small percentage (5.8%) of patients died. Patients who were unsuccessful in weaning from mechanical ventilation had a 10.24-fold chance of developing AKI.
Conclusion
mechanical ventilation use can cause damage to the renal function of patients hospitalized in the intensive care unit and that those with greater need to offer PEEP evolved with different severities and persistence of AKI.
Acute kidney injury; Respiration, artificial; Positive-pressure respiration; Intensive care units