Sintomas depressivos e distúrbios motores axiais em indivíduos com doença de Parkinson: um estudo transversal

Artigas, Nathalie Ribeiro; Dutra, Ana Carolina Leonardi; Soares, Nayron Medeiros; Pereira, Gabriela Magalhães; Leotti, Vanessa Bielefeldt; Krimberg, Julia Schneider; Pagnussat, Aline de Souza; Rieder, Carlos Roberto de Mello

Nathalie Ribeiro Artigas Address for correspondence Nathalie Ribeiro Artigas, (e-mail: nathalie.artigas@gmail.com).

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre RS, Brazil.

https://orcid.org/0000-0001-7204-9485

Ana Carolina Leonardi Dutra

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre RS, Brazil.

https://orcid.org/0000-0003-3453-0707

Nayron Medeiros Soares

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre RS, Brazil.

https://orcid.org/0000-0001-7830-8775

Gabriela Magalhães Pereira

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre RS, Brazil.

https://orcid.org/0000-0003-0284-6678

Vanessa Bielefeldt Leotti

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Epidemiologia, Departamento de Estatística, Porto Alegre RS, Brazil.

https://orcid.org/0000-0003-3860-9367

Julia Schneider Krimberg

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Porto Alegre RS, Brazil.

Pontifícia Universidade Católica do Rio Grande do Sul, Escola de Ciências da Vida e da Saúde, Porto Alegre RS, Brazil.

https://orcid.org/0000-0003-3108-000X

Aline de Souza Pagnussat

Programa de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre RS, Brazil.

https://orcid.org/0000-0001-7837-5855

Carlos Roberto de Mello Rieder

Programa de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre RS, Brazil.

Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Clínica Médica, Divisão de Neurologia, Porto Alegre RS, Brazil.

https://orcid.org/0000-0003-2950-7211

Address for correspondence Nathalie Ribeiro Artigas, (e-mail: nathalie.artigas@gmail.com).

Conflict of Interest The authors have no conflict of interests to declare.

Authors' Contributions All authors have made substantial contributions to all of the following: (1) the conception and design of the study, acquisition of the data, or analysis and interpretation of the data, (2) the drafting of the article or revising it critically for important intellectual content, and (3) the final approval of the version to be submitted.

Variables		With depressive symptoms		Without depressive symptoms		p-value
Variables		(n = 34)	SE or % or IQR	(n = 31)	SE or % or IQR	p-value
Age (years)^a a Variables described in mean (SE).		61.71	1.95	63.55	1.44	0.459^f f Student t-test.
Diagnostic time (years)^a a Variables described in mean (SE).		10.18	0.95	9.06	0.77	0.367^f f Student t-test.
Sex^b b Variables described in N (%).	Male	16	47.1	19	61.3	0.321^g g Chi-square test.
Sex^b b Variables described in N (%).	Female	18	52.9	12	38.7	0.321^g g Chi-square test.
Hoehn & Yahr^b b Variables described in N (%).	Stage 1	3	8.8	7	22.6	0.026^* * p ≤ 0.05. ^e e Fisher exact test.
	Stage 2	16	47.1	20	64.5
	Stage 3	11	32.4	4	12.9
	Stage 4	4	11.8	0	0
Motor subtypes^b b Variables described in N (%).	TD	9	26.5	16	51.6	0.117^g g Chi-square test.
	PIGD	20	58.8	13	41.9
	TI	5	14.7	2	6.5
MDS-UPDRS Score Part I^a a Variables described in mean (SE).		19.82	1.42	9.68	0.97	0.000^* * p ≤ 0.05. ^f g Chi-square test.
MDS-UPDRS Score Part II^a a Variables described in mean (SE).		20.53	1.4	14.97	1.47	0.008^* * p ≤ 0.05. ^f g Chi-square test.
MDS-UPDRS Score Part III^a a Variables described in mean (SE).		47.0	2.11	41.10	2.44	0.072^f g Chi-square test.
MDS-UPDRS Score Part IV^a a Variables described in mean (SE).		7.26	0.98	5.16	1.03	0.147^f g Chi-square test.
Total MDS-UPDRS Score^a a Variables described in mean (SE).		94.62	7.17	70.90	4.71	0.000^* * p ≤ 0.05. ^f g Chi-square test.
Sum of axial subscore MDS-UPDRS^c c Variables described in median (IQR).		6.0	14.0	4.0	5.0	0.033^* * p ≤ 0.05.
Posture subscore MDS-UPDRS^c c Variables described in median (IQR).		1.0	1.0	1.0	1.0	0.356
MiniBESTest (n = 56)^c c Variables described in median (IQR).		24.0	7.5	28.00	5.75	0.007^* * p ≤ 0.05. ^d d Mann-Whitney U test.
TMS^a a Variables described in mean (SE).		9.65	0.55	7.71	0.61	0.022^* * p ≤ 0.05. ^f g Chi-square test.
Head anteriorization angle (°)^c c Variables described in median (IQR).		23.2	12.67	23.01	11.6	0.948^f f Student t-test.
Trunk flexion angle (°)^c c Variables described in median (IQR).		4.38	4.89	2.91	4.44	0.212^f f Student t-test.
Hip flexion angle (°)^c c Variables described in median (IQR).		3.7	4.65	2.65	4.29	0.351^f f Student t-test.
Number of patients on antidepressant medication^b b Variables described in N (%).		21	61.8	12	38.7	0.084^g g Chi-square test.
Total LED (mg/day)^a a Variables described in mean (SE).		1,276.27	108.22	1,015.34	72.39	0.054^f f Student t-test.

Variables	r	p-value
Age	-0.009	0.945
Diagnostic time	0.121	0.338
Hoehn & Yahr	0.402	0.001^* * p ≤ 0.05.
MDS-UPDRS Score Part I	0.658	0.0^* * p ≤ 0.05.
MDS-UPDRS Score Part II	0.389	0.001^* * p ≤ 0.05.
MDS-UPDRS Score Part III	0.344	0.005^* * p ≤ 0.05.
MDS-UPDRS Score Part IV	0.24	0.054
Total MDS-UPDRS Score	0.516	0.0^* * p ≤ 0.05.
Sum of axial subscore MDS-UPDRS	0.397	0.001^* * p ≤ 0.05.
Posture subscore MDS-UPDRS	0.16	0.203
MiniBESTest (n- = 56)	-0.366	0.006^* * p ≤ 0.05.
TMS	0.402	0.001^* * p ≤ 0.05.
Head anteriorization angle (°)	0.088	0.487
Trunk flexion angle (°)	0.203	0.105
Hip flexion angle (°)	0.193	0.123
Total LED (mg/day)	0.314^# # Pearson correlation coefficients.	0.011^* * p ≤ 0.05.

Variables	R²	β	p-value
Head anteriorization angle	0.323	0.138	0.308
Trunk flexion angle	0.453	0.116	0.045^* * p ≤ 0.005.
Hip flexion angle	0.167	0.110	0.052

[1] Address for correspondence Nathalie Ribeiro Artigas, (e-mail: nathalie.artigas@gmail.com).

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Sintomas depressivos e distúrbios motores axiais em indivíduos com doença de Parkinson: um estudo transversal

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