The Authors, studying the clinical progress in five cases of multiform glioblastomata, observed interesting features peculiar to this type of neoplasm. Symptoms can be classified into four groups: a) pseudomeningo-encephalitic, b) apopletic, c) psychotic, d) tumoral. Several explanations were considered to explain the pathogenesis of these groups. The latter group is the least frequent. As a result, it has been proposed to name the multiform glioblastomata, paradoxal brain tumors, due to the fact that only excepcionally and especially in the early stages, do these tumor offer local and general signs and symptoms of a typical intracranial tumor. All patients were operated but none survived. Even in those in which ample removal was possible, none survived for more than one year. Results following surgical or deep X-ray therapy are discussed. The Authors indicate a compromising procedure, i. e. treatment by both X-ray and surgery.
