Therapeutic regimen compliance was assessed in 84 epileptic patients. The compliance measurement was biased on two interviews, one has been taken by the physician and the other by the nurse. Most patients (72,6%) were detected as non-compliance by the nurse's interview. The forgetfulness of drugs intake was found in 50% subjects. The treatment length and changes from Medical Centers were negatively associated with compliance. Our findings point out the important role of detailed interview in order to detect the most influencing factors in compliance.