TIME TRENDS OF <i>HELICOBACTER PYLORI</i> PREVALENCE IN ITAJAÍ - SC: A RETROSPECTIVE STUDY OF 25 YEARS BASED ON ENDOSCOPIC DATABASE

FERRARI, Fangio; DUTRA, Elisa Cantú Germano; ZANARDI, Henrieli Correia; SCOLARO, Bruno Lorenzo; FERRARI, Odemari Miranda

doi:10.1590/S0004-2803.201900000-13

Acessibilidade / Reportar erro

Brasil

Arquivos de Gastroenterologia

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

ORIGINAL ARTICLE • Arq. Gastroenterol. 56 (01) • Jan-Mar 2019 • https://doi.org/10.1590/S0004-2803.201900000-13 copy

TIME TRENDS OF HELICOBACTER PYLORI PREVALENCE IN ITAJAÍ - SC: A RETROSPECTIVE STUDY OF 25 YEARS BASED ON ENDOSCOPIC DATABASE

Tendências temporais da prevalência de Helicobacter pylori em Itajaí - SC: um estudo retrospectivo de 25 anos baseado em banco de dados endoscópicos

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

BACKGROUND:

The bacterium Helicobacter pylori is strongly associated with the development of gastric adenocarcinoma. Currently, the prevalence in developed countries is 40%, but this value increases considerably in developing countries, which can reach rates bigger than 90%.

OBJECTIVE:

The objective of this study was to determine the mean and annual prevalence of Helicobacter pylori infection in patients from Itajaí during the period from July 1992 to April 2016, as well as the gender and age groups most affected.

METHODS:

After consent of the clinical director of the Gastroclinica Itajaí and confidentiality commitment about the research, the database of the Endoscopy Service of the clinic was evaluated. All the patients who underwent their first upper digestive endoscopy with urease test and/or histological analysis were included. The data were submitted to statistical analysis of prevalence by gender, age group and years of study, with subsequent correction through the confidence interval.

RESULTS:

The mean prevalence of Helicobacter pylori infection thru all years of study was 50.07%. With the calculation of the annual prevalences, it was evident the gradual reduction of infection in the population of Itajaí, that was 81.3% in 1992, declining to 33% in the year of 2016. When classifying the prevalence of infection by gender, it was higher in males (53.59%), and gender distribution by age group showed no statistically significant difference among genders between the ages of 40 and 80 years. In relation to the age group, the highest prevalence was in the group between 40 and 49 years.

CONCLUSION:

Although this study is retrospective and based on endoscopic database analysis, without access to clinical data of patients such as prior use of proton pump inhibitor and antibiotics to endoscopy, its results are important because they may reflect the current panorama of Helicobacter pylori infection in the city under study, where it has been presenting a gradual reduction of prevalence over the years, with current rates similar to that of developed countries (33%). Future studies are needed to confirm our data.

HEADINGS:
Helicobacter infections; Prevalence; Epidemiology

Age group (years)	< 20 years	20-29	30-39	40-49	50-59	60-69	70-79	> 80
Total Hp.+ (n)
Female	729	2600	2709	2444	1832	1050	472	123
Male	296	1852	2206	1780	1182	739	315	68
Hp.+ (%) with CI P=0.05
Female	29.5% (26.2-32.8)	41.4% (39.5-43.3)	51.5% (49.6-53.4)	56.7% (54.7-58.7)	51.9%(49.6-54.1)	42.8% (39.8-45.8)	39.6% (35.2-44.0)	26.0% (18.3-33.8)
Male	40.5% (34.9-46.1)	52.4% (50.1-54.7)	58.3% (56.2-60.4)	58.0% (55.7-60.3)	54.9% (52.1-57.7)	42.9% (39.3-46.5)	37.8% (32.4-43.1)	42.6% (30.9-54.4)

Age group (years)	< 20 years	20-29	30-39	40-49	50-59	60-69	70-79	> 80
Total Hp.+ (n)	1025	4452	4915	4224	3014	1789	787	191
Hp.+ (%) with CI P=0.05	32.7% (29.8-35.6)	46.0% (44.5-47.4)	54.5% (53.2-55.9)	57.2% (55.8-58.7)	53.1% (51.3-54.8)	42.8% (40.5-45.1)	38.9% (35.5-42.3)	32.6% (25.9-39.2)

Year	1992	1993	1994	1995	1996	1997	1998	1999	2000	2001	2002	2003	2004
Total n	22	112	133	478	684	926	726	846	1097	1640	1448	1180	1066
Female	10	38	49	198	323	496	413	476	653	977	872	710	633
Male	12	74	84	280	361	430	313	370	444	663	576	470	433

Hp. + n	14	91	104	325	435	609	478	524	665	965	821	672	615
(%)	63.6%	81.3%	78.2%	68%	63.6%	65.8%	65.8%	61.9%	60.6%	58.8%	56.7%	56.9%	57.7%
Female (n)	5	27	37	120	201	324	263	287	392	553	482	391	358
(%)	50%	71%	75.5%	60.6%	62.2%	65.3%	63.6%	60.3%	60%	56.6%	55.3%	55%	56.6%
Male (n)	9	64	67	205	234	285	215	237	273	412	339	281	257
(%)	75%	86.5%	79.8%	73.2%	64.8%	66.2%	68.6%	64%	61.5%	62.1%	58.9%	59.8%	59.4%
Year	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016	Sum of all years
Total (n)	940	976	1011	929	734	838	731	598	916	983	1017	367	20398
Female	552	642	615	597	420	516	462	348	578	590	592	200	11960
Male	388	334	396	332	314	322	269	250	338	393	425	167	8438

Hp. + n	471	441	362	362	284	311	246	209	316	346	350	121	10213
(%)	50.1%	45.2%	39%	39%	38.7%	37.1%	33.7%	34.9%	34.5%	35.2%	34.4%	33%	50.07%
Female (n)	270	280	213	213	150	183	155	117	189	187	191	68	5691
(%)	48.9%	43.6%	35.6%	35.6%	35.7%	35.4%	33.5%	33.6%	32.7%	31.6%	32.2%	34%	47.58%
Male (n)	201	161	149	149	134	128	91	92	127	159	159	53	4522
(%)	51.8%	48.2%	44.8%	44.8%	42.6%	39.7%	33.8%	36.8%	37.5%	40.4%	37.4%	31.7%	53.59%

Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. Rua Dr. Seng, 320, 01331-020 São Paulo - SP Brasil, Tel./Fax: +55 11 3147-6227 - São Paulo - SP - Brazil
E-mail: secretariaarqgastr@hospitaligesp.com.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding author: Fangio Ferrari. E-mail: fangioferrari@gmail.com.