Rare association between giant-cell aortitis and giant-cell aortic valvulitis

Giant cell arteritis (GCA) is a type of chronic vasculitis that affects medium and large-caliber arteries, frequently related to aortic involvement and, consequently, to aneurysm formation. However, associated valvulitis with giant cells is uncommon. We describe the case of a 50-year-old female patient with aortic aneurysm and valvular insufficiency, whose anatomopathological examination revealed giant-cell aortic valvulitis associated with giant cell aortitis.

Keywords
Aorta, Thoracic; Aortic Diseases; Aortic Aneurysm; Aortic Valve; Aortic Valve Insufficiency

Authorship

Georgina del Cisne Jadán Luzuriaga

data collection

analysis

manuscript preparation

Universidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Miocardiopatias e Doenças da Aorta, São Paulo, SP, BrasilUniversidade de São PauloBrasilSão Paulo, SP, BrasilUniversidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Miocardiopatias e Doenças da Aorta, São Paulo, SP, Brasil

http://orcid.org/0000-0002-6000-1297

Ricardo Ribeiro Dias

literature review

Universidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Cirurgia Cardiovascular, São Paulo, SP, BrasilUniversidade de São PauloBrasilSão Paulo, SP, BrasilUniversidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Cirurgia Cardiovascular, São Paulo, SP, Brasil

http://orcid.org/0000-0001-6206-7081

José Augusto Duncan Santiago

literature review

Vagner Madrini Junior

literature review

http://orcid.org/0000-0002-1116-6554

Walther Yoshiharu Ishikawa

data collection

Universidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Imagem Cardiovascular, São Paulo, SP, BrasilUniversidade de São PauloBrasilSão Paulo, SP, BrasilUniversidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Imagem Cardiovascular, São Paulo, SP, Brasil

http://orcid.org/0000-0002-5909-5126

Fabio Fernandes

manuscript preparation

http://orcid.org/0000-0002-9323-8805

Vera Demarchi Aiello

data collection

manuscript review

editing the manuscript

Universidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Anatomia Patológica, São Paulo, SP, BrasilUniversidade de São PauloBrasilSão Paulo, SP, BrasilUniversidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Departamento de Anatomia Patológica, São Paulo, SP, Brasil

http://orcid.org/0000-0002-4185-9423

Conflict of interest: None.

CorrespondenceGeorgina del Cisne Jadán Luzuriaga Universidade de São Paulo, Faculdade de Medicina, Instituto do Coração (InCor), Departamento de Miocardiopatias e Doenças da Aorta Av. Dr. Enéas Carvalho de Aguiar, 44, CEP 05403-000, São Paulo, SP, Brasil Phone: +55 (11) 2661-5000geojadan@gmail.com

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (4)

Thumbnail

Figure 1
Contrast-enhanced chest CT angiography showing dilatation of the aortic root with a diameter greater than 50 mm in the ascending segment, the ascending segment 45 mm, the aortic arch 32 mm and the descending segment 22 mm.

Thumbnail

Figure 2
Photomicrographs of an aortic leaflet. In the panel A - with diffuse thickening and chronic inflammatory infiltrate; in the panel B - the arrows point to a Langerhans-type giant cell within the inflammatory infiltrate. Hematoxylin-eosin staining, objective magnifications 10x and 40x, respectively.

Thumbnail

Figure 3
Photomicrographs of the aortic wall showing in panel A - the diffuse involvement of the layers by chronic inflammatory infiltrate; in panel B - a close-up view shows a giant cell within the inflammatory infiltrate. Hematoxylin-eosin staining, objective magnifications 5x and 40x respectively.

Thumbnail

Figure 4
Photomicrographs of the aortic and valvar tissue submitted to immunohistochemical reactions for macrophages (CD68 antigen). In A - the positive cells are concentrated in the external half of the aortic wall, near the adventitia; Panel B - depicts positive macrophages in one aortic leaflet. Objective magnifications are respectively A - 5x; and B - 20x. Mouse monoclonal antibody CD68 (clone KP1), counter-staining with Harry’s Hematoxylin.

Figure 1 Contrast-enhanced chest CT angiography showing dilatation of the aortic root with a diameter greater than 50 mm in the ascending segment, the ascending segment 45 mm, the aortic arch 32 mm and the descending segment 22 mm.

Figure 2 Photomicrographs of an aortic leaflet. In the panel A - with diffuse thickening and chronic inflammatory infiltrate; in the panel B - the arrows point to a Langerhans-type giant cell within the inflammatory infiltrate. Hematoxylin-eosin staining, objective magnifications 10x and 40x, respectively.

Figure 3 Photomicrographs of the aortic wall showing in panel A - the diffuse involvement of the layers by chronic inflammatory infiltrate; in panel B - a close-up view shows a giant cell within the inflammatory infiltrate. Hematoxylin-eosin staining, objective magnifications 5x and 40x respectively.

Figure 4 Photomicrographs of the aortic and valvar tissue submitted to immunohistochemical reactions for macrophages (CD68 antigen). In A - the positive cells are concentrated in the external half of the aortic wall, near the adventitia; Panel B - depicts positive macrophages in one aortic leaflet. Objective magnifications are respectively A - 5x; and B - 20x. Mouse monoclonal antibody CD68 (clone KP1), counter-staining with Harry’s Hematoxylin.

How to cite

copy

Hospital Universitário da Universidade de São Paulo Hospital Universitário da Universidade de São Paulo, Av. Prof. Lineu Prestes, 2565 - Cidade Universitária, 05508-000 - São Paulo - SP - Brasil, (16) 3307-2068, (16) 3307-2068 - São Paulo - SP - Brazil
E-mail: autopsy.hu@gmail.com

Acompanhe os números deste periódico no seu leitor de RSS

Versão para download de PDF

PDF

Inglês

Versões e tradução automática

Versão original do texto

English

Tradução automática

Google Translator
Microsoft Translator

Como citar

RIS

BIBTEX

Outros formatos de citação e exportação:

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
E-mail: scielo@scielo.org

Leia a Declaração de Acesso Aberto

Métricas

Rare association between giant-cell aortitis and giant-cell aortic valvulitis

PlumX

Mensagem

[1] Conflict of interest: None.