Effect of propranolol on capsular reaction around silicone implants in guinea pigs

Mesquita, Charles Jean Gomes de; Guimarães, Sérgio Botelho; Leite Filho, José Alberto Dias; Maciel, Felipe Silva; Rocha, José Lima de Carvalho; Leite, José Alberto Dias

doi:10.1590/S0102-86502015001000004

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Acta Cirúrgica Brasileira

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Original Articles • Acta Cir. Bras. 30 (1) • Jan 2015 • https://doi.org/10.1590/S0102-86502015001000004 copy

Effect of propranolol on capsular reaction around silicone implants in guinea pigs¹ 1 Research performed at Experimental Surgery Lab (LABEX), Medical Course, Christus Universitary Center (UNICHRISTUS), Fortaleza-CE, Brazil. Part of Master degree thesis, Postgraduate Program in Surgery, Federal University of Ceara (UFC). Tutor: Prof. Dr. José Alberto Dias Leite.

Authorship SCIMAGO INSTITUTIONS RANKINGS

PURPOSE:

To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.

METHODS:

Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).

RESULTS:

Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.

CONCLUSION:

Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.

Silicone Elastomers; Implant Capsular Contracture; Collagen; Propranolol; Guinea Pigs

Group	Acute inflammation	Post-operative day (%)
Group	Acute inflammation	7^th	14^th	21^st
Control	Absent/Discrete	33.3	66.7	83.3
Control	Moderate/Intense	66.7	33.3	16.7
Propranolol	Absent/Discrete	33.3	83.3	66.7
Propranolol	Moderate/Intense	66.7	16.7	33.3

Group	Chronic inflammation	Post-operative day (%)
Group	Chronic inflammation	7^th	14^th	21^st
Control	Absent/Discrete	66.7	83.3	0.0
Control	Moderate/Intense	33.3	16.7	100
Propranolol	Absent/Discrete	83.3	66.7	83.3
Propranolol	Moderate/Intense	16.7	33.3	16.7

	Ctrl d7^§	Prop d7^#	Ctrl d14	Prop d14	Ctrl d21	Prop d21
Number of values	54	54	54	54	54	54
Minimum	2.818	2.776	1.248	5.875	5.245	1.587
25% Percentile	5.919	5.752	7.028	9.943	11.58	4.036
Median	9.585	8.357	9.849	11.85	16.59	7.746
75% Percentile	17.61	11.72	12.82	15.22	23.13	11.46
Maximum	38.16	37.49	19.19	28.33	76.15	26.05
Mean	12.14	10.62	9.978	13.22	20.77	8.313
Std. Deviation	7.966	7.940	3.838	5.063	14.58	5.248
Std. Error	1.084	1.081	0.522	0.689	1.984	0.714
Lower 95% CI	9.964	8.452	8.931	11.83	16.79	6.881
Upper 95% CI	14.31	12.79	11.03	14.60	24.75	9.746

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
E-mail: actacirbras@gmail.com

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[1] Correspondence: Sérgio Botelho Guimarães Rua Barão de Aratanha, 1465 60050-071 Fortaleza - CE Brasil Tel.: (55 85)3226-2400 sergiobotelho@terra.com.br