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Capsiate treatment in liver surgeries may compromise its recovery1 1 Research performed at Laboratory of Biological Tests, Faculty of Nutrition, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Brazil.

Abstract

Purpose:

To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats.

Methods:

The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH.

Results:

Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations.

Conclusion:

Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery.

Key words:
Alanine Transaminase; Aspartate Aminotransferases; Apoptosis; Mitotic Index; Rats.

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