SUMMARY
Visual impairment due to important corneal opacity in aniridia is not common, and there are very few reports of corneal transplantation in this condition. We report two cases of penetrating keratoplasty in two patients with familiai aniridia, discussing the technique of the procedure. One patient had also associated Peters anomaly and congenital rubella, and the other cataract and congenital syphilis, findings that are discussed. Significative improvement in visual acuity were achieved in both cases, during a follow-up period of 32 months. Persistent epithelial defect, vortex (whorl) keratopathy, two episodes of allograft rejection and glaucoma were the post-operative complications that occured in one patient and were clinically controlled.