Purpose: 58 cases with a diagnosis of endophthalmitis were reviewed in the attempt to obtain regional characte-ristics of this pathology. Predisposing factors, clinical presentation, ancillary examination, treatment and functional results were analyzed. Methods: Analysis of charts of patients treated in the Clinical Hospital of Ribeirão Preto's Medical School (USP), from 1993 to 1998. Results: Trauma and surgery were the most frequent causes (39.65% each one). The most common clinical presentation was pain and decrease of visual function associated with hypopyon and conjunctival injection. In 70.48% of cases samples for culture were collected and 85.36% of the specimens were positive. The most frequent microorganism was S. aureus (26.08%), followed by S. epidermidis and P. aeruginosa (13.04% each one). All isolated species were susceptible to vancomicyn and ceftazidime. In 65.51% of the cases no light perception was the final visual acuity. Conclusions: These results suggest some changes that might be performed to improve prognosis of endophthalmitis, such as using intraocular vancomicyn and ceftazidime
