SUMMARY
A clinic, randomized and double masked study was conducted in 83 patients with presumed acute bacterial conjunctivitis (53 of them culture-proven cases of bacterial conjuntivitis).
Regarding the causative agents - S. aureus, S. epidermidis and Streptococos sp - the statistical analysis of the two antibiotics didn 't show significant difference concerning in vitro sensibility. Regarding the agents - S. aureus and S. epidermidis - there was no significant difference in bacterial erradication with the use of two combinations of drugs.
The comparison of the effect of the combinations of the drugs on microbiological and clinical efficacy demonstrates that there is no significant difference between them. The microbiological and clinical rate from the association of ciprofloxacin and dexamethasone was respectively 84.6% and 92.3% and from gentamicin and dexamethasone was respectively 70.4% and 81.5%.
No severe adverse reaction was detected - 7.1% (three cases) of the patients who received ciprofloxacindexamethasone had punctate epithelial erosions, puntacte epithelial keratitis and crystalline deposits on ciliae. 9.8% (four cases) of the patients who were given gentamycin-dexamethasone had punctate epithelial erosions or punctate epithelial keratitis.
Key words:
Acute bacterial conjunctivitis; Ciprofloxacin; Gentamicin; Dexamethasone