Multicentric peripheral T-cell lymphoma, bilateral granulosa cell tumor, and papillary ovarian adenocarcinoma in a female dog - case report

[Linfoma multicêntrico de células T periférico, tumor de células da granulosa e adenocarcinoma papilar ovariano em uma cadela - relato de caso]

ABSTRACT

The frequency of ovarian neoplasms in dogs is low, and these tumors are often underdiagnosed mainly due to nonspecific clinical signs. Multiple ovarian tumors are rarely described in dogs and can be of primary or secondary origin. Lymphomas, in turn, are among the most common malignant neoplasms in dogs, with a variable clinical course. This report describes a case of multiple concomitant ovarian tumors and a multicentric lymphoma in a dog, diagnosed histologically and confirmed by immunohistochemistry. The right and left ovaries and mesenteric lymph node of a 14-year-old mixed breed female dog were received for histopathological evaluation. Histologically, a multicentric small to intermediate cell lymphoma was diagnosed in the lymph node and both ovaries, in addition to a bilateral granulosa cell tumor and papillary adenocarcinoma in one of the ovaries. Immunohistochemistry determined the diagnosis of multicentric peripheral T-cell lymphoma. Coexisting ovarian tumors are rarely described in the literature but can occur. This is the first report of these three neoplasms occurring concomitantly in the same organ. Therefore, clinicians and pathologists should be aware of this possibility when evaluating ovaries.

Keywords:
multiple tumors; epithelial ovarian tumor; sex cord stromal tumor; multicentric lymphoma