The effects of propofol and ketamine on physiological parameters, electrocardiography, and analgesia were evaluated in twelve dogs that received propofol-ketamine (0.4mg/kg/min + 0.2mg/kg/min, n=6, PK group) or propofol-S+ketamine (0.4mg/kg/min + 0.1mg/kg/min, n=6, PKS group) after induction of anesthesia with propofol (8.0mg/kg). Assessments of pain; heart rate (HR); electrocardiography (ECG); respiratory rate (RR); systolic, medium, and diastolic arterial pressures (SAP, MAP, DAP); saturation of hemoglobin (SpO2); and rectal temperature (RT) were conducted. There was a rise in HR with no electrocardiographically changes, but an increase in amplitude of T wave in one animal of each group. RR decreased and SpO2 were lower than 90% in two moments of both groups. SAP, MAP, and DAP were reduced during the experimental period, but with no statistical difference between the protocols. There was no analgesia in seven bitches, mild analgesia was observed in three, and satisfactory analgesia in only two animals tested. It was concluded that the protocols are safe for dogs, but there is no analgesia for surgical procedures. The changes in ECG are related to HR and amplitude of T wave, which may be due to myocardial hypoxia.
dog; propofol; ketamine; S+ ketamine; electrocardiography
