Evaluation of renal function in patients with psoriasis using immunobiologicals

Melgaço, Sarah Suyanne Carvalho; Silva Junior, Geraldo Bezerra da; Dantas, Amanda Maria Menezes; Vasconcelos, Ana Mirella Arcanjo; Siqueira, Verônica Riquet de; Vieira, Ana Patrícia Freitas; Daher, Elizabeth de Francesco

doi:10.1590/abd1806-4841.20132035

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Communication • An. bras. dermatol. 88 (4) • Aug 2013 • https://doi.org/10.1590/abd1806-4841.20132035 copy

Evaluation of renal function in patients with psoriasis using immunobiologicals^* * Study conducted at the Faculty of Medicine, Federal University of Ceará (UFC) - Fortaleza (CE), Brazil.

Avaliação da função renal de pacientes com psoríase em uso de imunobiológicos

Authorship SCIMAGO INSTITUTIONS RANKINGS

The aim of this study was to evaluate renal function in patients with psoriasis using immunobiologicals. A prospective study was conducted with 15 patients with confirmed diagnosis of psoriasis who were starting to use immunobiologicals. The mean age was 41±11 years, with 60% females. The mean time of disease was 11±6.6 years. Significant changes in creatinine and creatinine clearance were not observed in the course of the study. There was an increase in transaminases and a decrease in magnesium levels.

Drug toxicity; Immunosuppressive agents; Psoriasis; Renal insufficiency; Transaminases

	Pre-treatment	Post-treatment	P
Hb (g/dL)	14.1±1.8	14.6±1.5	0.14
Ht (%)	42.2±4.3	43.3±4.4	0.27
White blood count (mm3)	6977±1886	6331±2328	0.27
Platelets (mm3)	250000±57909	245700±38511	0.79
ESR (mm)	22±19	23±17	0.73
Total Cholesterol (mg/dL)	197±56	194±46	0.73
HDL (mg/dL)	43±12	44±14	0.61
LDL (mg/dL)	131±43	114±39	0.29
Triglycerides (mg/dL)	140±82	190±129	0.05
Fast Glucose (mg/dL)	74±23	85±16	0.33
C-reactive protein (mg/dL)	2.5±5.3	0.8±1.2	0.38
Na (mEq/L)	138±3.5	137±4.8	0.67
K (mEq/L)	4.2±0.3	4.1±0.2	0.09
Ca (mg/dL)	9.0±0.4	8.9±0.5	0.43
Mg (mEq/L)	2.0±0.3	1.7±0.1	0.01
Urea (mg/dL)	26±8.0	27±10	0.84
Creatinine (mg/dL)	0.78±0.11	0.79±0.17	0.8
Albumin (g/dL)	4.21±0.35	4.26±0.27	0.27
Globulins (g/dL)	3.0±0.5	2.9±0.5	0.69
AST (IU/L)	24.5±6.08	162.6±469.2	0.0001
ALT (IU/L)	24.1±8.8	148±410	0.0001
Amilase (IU/L)	65±21	73±32	0.35

	Pre-treatment	Post-treatment	P
Creatinine Clearance	90.02±41.6	95.31±38.77	0.85
Microalbuminuria	5.6±2.9	10.7±7.1	0.14
FEK %	40.27±26.25	35.36±12.9	0.63
Urine specific gravity	1015±3.6	1013±5.1	0.5
Urine pH	5.8±0.7	5.9±0.7	0.76

Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br

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Evaluation of renal function in patients with psoriasis using immunobiologicals* * Study conducted at the Faculty of Medicine, Federal University of Ceará (UFC) - Fortaleza (CE), Brazil.

Avaliação da função renal de pacientes com psoríase em uso de imunobiológicos

Evaluation of renal function in patients with psoriasis using immunobiologicals^* * Study conducted at the Faculty of Medicine, Federal University of Ceará (UFC) - Fortaleza (CE), Brazil.