ABSTRACT The dynamic balance of the lower limbs has shown great importance in accomplishing activities of daily living, especially for walking and maintenance in the orthostatic position. In this context, individuals with knee osteoarthritis have changes in their physical capacity, mainly due to joint changes and muscular wear. The instrument called OctoBalance® is one of the most used to evaluate this balance, which analyses four different executions of movement in the limbs. However, individuals with knee osteoarthritis cannot perform this evaluation due to the need for single limb support during movements. This study aimed to verify whether it is reproducible to perform the dynamic balance evaluation of lower limbs with a reduction of 10% of body weight through a suspension system. A cross-sectional study was carried out with 2 collections with a 48-hour interval between them, using the Lower Body Test performed with OctoBalance®. The dynamic balance test followed the protocol of 3 repetitions observing the learning factor and then 3 repetitions where the values were collected, with the suggested adaptation for all 4 diagonals in both limbs. The interclass correlation index (ICI), coefficient of variation (CV), estimative standard error (EEE) and minimum detectable difference (MDD) were calculated as indicators of reproducibility. Also, Bland-Altman Graphs were used for visual verification of the agreement between the means. Results: The reliability tests showed a very high interclass correlation through the ICI and low variation values for all the movements evaluated through the CV. The EEE and MDD calculations showed positive responses for greater reliability, and the Bland-Altman graphs showed an agreement between the means. Reproducibility was positive for the Lower Body Test with the Octobalance® platform for the evaluation of lower limb dynamic balance in women with knee osteoarthritis.

Resumo O grupo de colaboradores do LARIISA realiza pesquisa e desenvolvimento de soluções tecnológicas para apoio à tomada de decisão em sistemas de saúde desde 2009. Dentre as soluções produzidas está o GISSA®, sistema em nuvem resultado da evolução científica e tecnológica do projeto LARIISA. O objetivo do presente artigo é descrever a trajetória de evolução do GISSA®, ferramenta tecnológica que apoia a Estratégia de Saúde da Família no nordeste do Brasil, apontando desafios, caminhos e potencialidades. Trata-se de um estudo descritivo e exploratório, baseado em fontes secundárias do IBGE, INMET, SINAN, SIM e SINASC, com análise quantitativa a partir de modelos de aprendizagem de máquina aplicados na criação de microserviços em saúde digital. Operando nas regiões nordeste e sudeste, o GISSA® disponibiliza informações que qualificam o processo de tomada de decisão de gestores de saúde e, consequentemente, contribui para aperfeiçoar a gestão do sistema de saúde municipal.

Abstract The LARIISA collaborators group has been conducting research and development of technological solutions to support decision-making in health systems since 2009. GISSA, a cloud system resulting from the scientific and technological evolution of the LARIISA project, is among the solutions produced. This paper aims to describe the developing trend of GISSA©, a technological tool supporting the Family Health Strategy in northeastern Brazil, pointing out challenges, paths, and potentialities. This is a descriptive and exploratory study, based on secondary sources from the IBGE, INMET, SINAN, SIM, and SINASC, with quantitative analysis based on machine-learning techniques applied to create digital health microservices. Operating in the northeast and southeast regions, GISSA© provides information that qualifies health managers’ decision-making process, improving the municipal health system’s management.

Resumo O grupo de colaboradores do LARIISA realiza pesquisa e desenvolvimento de soluções tecnológicas para apoio à tomada de decisão em sistemas de saúde desde 2009. Dentre as soluções produzidas está o GISSA®, sistema em nuvem resultado da evolução científica e tecnológica do projeto LARIISA. O objetivo do presente artigo é descrever a trajetória de evolução do GISSA®, ferramenta tecnológica que apoia a Estratégia de Saúde da Família no nordeste do Brasil, apontando desafios, caminhos e potencialidades. Trata-se de um estudo descritivo e exploratório, baseado em fontes secundárias do IBGE, INMET, SINAN, SIM e SINASC, com análise quantitativa a partir de modelos de aprendizagem de máquina aplicados na criação de microserviços em saúde digital. Operando nas regiões nordeste e sudeste, o GISSA® disponibiliza informações que qualificam o processo de tomada de decisão de gestores de saúde e, consequentemente, contribui para aperfeiçoar a gestão do sistema de saúde municipal.

Abstract The LARIISA collaborators group has been conducting research and development of technological solutions to support decision-making in health systems since 2009. GISSA, a cloud system resulting from the scientific and technological evolution of the LARIISA project, is among the solutions produced. This paper aims to describe the developing trend of GISSA©, a technological tool supporting the Family Health Strategy in northeastern Brazil, pointing out challenges, paths, and potentialities. This is a descriptive and exploratory study, based on secondary sources from the IBGE, INMET, SINAN, SIM, and SINASC, with quantitative analysis based on machine-learning techniques applied to create digital health microservices. Operating in the northeast and southeast regions, GISSA© provides information that qualifies health managers’ decision-making process, improving the municipal health system’s management.

Abstract Aim: To investigate the hypothesis that the resistance exercise (RE) may be safer if the blood pressure (BP) is properly controlled through antihypertensive pharmacological treatment in hypertensive middle-aged women. Methods: The final sample was comprised of 19 hypertensive women, with an average age of 58±5 years and a body mass index of 29±5 Kg/m2. They were divided into three groups: controlled (n=6), uncompensated (n=8), and untreated (n=5). The subjects from all groups were submitted to a test of maximal strength on extensor chair and held a session of RE (knee extension, 3x12 to 60% 1RM) and the cardiovascular response (BP and heart rate) was monitored continuously by photoplethysmography during exercise and until five minutes after exercise (recovery). Results: Systolic BP (SBP) and diastolic BP (DBP) responses were lower in the controlled group compared to the other groups (p<0.05). The heart rate was not different between groups, while the double product was lower in the controlled group compared to the untreated group (p<0.05). The SBP and DBP peaks were lower in the controlled group compared to the other groups (p<0.05). Conclusion: The BP increases significantly during RE when the hypertension is not controlled. Pharmacological control was shown to be effective in preventing the increase of BP during the performance of the RE.

Abstract BRS FC104 is a carioca seeded common bean cultivar with super-early maturity (mean of 65 days; emergence to physiological maturity) and disease resistance superior to other early maturity carioca seeded cultivars. Is is recommended for growing in 21 Brazilian states and has high yield potential (3792 kg ha-1), a mean yield of 2186 kg ha-1, and 6.9% higher mean of the relative yield compared to the control cultivars.

Resumo Fundamento: O D-limoneno (DL) é um monoterpeno e o principal componente do óleo essencial de frutas cítricas. Ele apresenta atividades anti-hiperglicêmicas e vasodilatadoras. Objetivos: Este estudo avaliou os efeitos cardiovasculares e antiarrítmicos potenciais do DL em ratos. Métodos: Os parâmetros hemodinâmicos e eletrocardiográficos (ECG) foram mensurados em ratos Wistar machos que, sob anestesia, tiveram a aorta abdominal e a veia cava inferior canuladas e receberam eletrodos implantados subcutaneamente. Na abordagem in vitro, o coração foi removido e perfundido utilizando a técnica de Langendorff. O nível de significância adotado foi de 5% (p < 0,05). Resultados: DL, nas doses de 10, 20 e 40 mg/kg (i.v), produziu bradicardia intensa e persistente associada à hipotensão. A bradicardia com QTc prolongado foi observada no registro in vivo do ECG. No modelo in vivo de arritmia induzida por Bay K8644, DL (10 mg / kg) houve diminuição do escore da arritmia de 15,33 ± 3,52 para 4,0 ± 2,64 u.a (p < 0,05, n = 4). Em corações perfundidos isolados, o DL (10-3 M) promoveu reduções significativas na frequência cardíaca (de 228,6 ± 8,5 ms para 196,0 ± 9,3 bpm; p < 0,05) e na pressão desenvolvida do ventrículo esquerdo (de 25,2 ± 3,4 para 5,9 ± 1,8 mmHg; n = 5, p < 0,05). Conclusões: O DL produz bradicardia e atividade antiarrítmica no coração de ratos.

Abstract Background: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. Objectives: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Methods: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). Results: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10-3 M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). Conclusions: DL produces bradycardia and antiarrhythmic activity in rat heart.

Abstract Background: Neuromuscular electrical stimulation seems to be a promising option to intensify the rehabilitation and improve the exercise capacity of patients in the immediate postoperative period of cardiac surgery. Objective: This study aimed to evaluate the hemodynamic (heart rate, systolic blood pressure, diastolic blood pressure, and mean blood pressure) and respiratory (respiratory rate and oxygen saturation) responses to neuromuscular electrical stimulation in the immediate postoperative period in patients submitted to cardiac surgery and to verify its feasibility and safety. Methods: This is a pilot randomized controlled trial, wherein critical patients in the immediate postoperative period of cardiac surgery were randomly assigned to a control group, using sham neuromuscular electrical stimulation, or an experimental group, submitted to neuromuscular electrical stimulation sessions (FES), for 60 min, with a 50-Hz frequency, 200-µs pulse duration, time on: 3 s, and time off: 9 s. Data distribution was evaluated by the Shapiro-Wilk test. The analysis of variance was used and a p-value < 0.05 was considered significant. Results: Thirty patients were included in the study. The neuromuscular electrical stimulation was applied within the first 23.13 ± 5.24 h after cardiac surgery, and no changes were found regarding the hemodynamic and respiratory variables between the patients who underwent neuromuscular electrical stimulation, and those in the control group. Conclusions: In the present study, neuromuscular electrical stimulation did not promote changes in hemodynamic and respiratory responses of patients in the immediate postoperative period of cardiac surgery.

Abstract BRS FP403 is a common bean cultivar from the black bean market class with high grain yield and yield potential, high commercial and cooking quality, and moderate resistance to fusarium wilt (Fusarium oxysporum f. sp. phaseoli) and root rot diseases (Fusarium solani f. sp. phaseoli and Rhizoctonia solani).

RESUMO A doença de Paget Óssea é uma afecção crônica, caracterizada por distúrbio focal da absorção e formação ósseas, podendo levar a deformidades anatômicas, dor, fraturas e malignização das lesões. É frequente no Reino Unido, Austrália, Nova Zelândia e América do Norte. Mantém forte relação de incidência com parentes de primeiro a terceiro graus. Sua etiologia ainda permanece incerta e o tratamento se baseia no controle da doença, com uso de bisfosfonados, visando melhora dos sintomas e das alterações laboratoriais. O tratamento cirúrgico também pode ser necessário, para correção de deformidades ou para tratamento de fraturas. Este estudo compilou oito pacientes em acompanhamento pela doença de Paget Óssea, no Ambulatório de Ortopedia deste hospital, acerca do tratamento realizado e como evoluíram. Dentre os pacientes acompanhados, houve um caso de carcinoma de próstata concomitante ao Paget, chamando atenção para outras patologias ósseas que são diagnósticos diferenciais ou coexistem com a doença. Nível de evidência IV, Tipo de Estudo: Série de Casos.

ABSTRACT Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation. It is common in the UK, Australia, New Zealand, and North America and has a strong hereditary component, affecting first- to third-degree relatives. The etiology remains unclear and treatment is based on control of the disease with bisphosphonates, with the aim of relieving symptoms and correcting laboratory abnormalities. Surgical treatment may also be necessary to correct deformities or treat pathological fractures. This study evaluated the management and course of 8 patients with Paget's disease of bone, followed in the Orthopedic Clinic of this hospital. Among these patients, 1 had concomitant advanced prostate carcinoma, highlighting the association between Paget's disease and secondary bone diseases that can affect the differential diagnosis. Level of evidence IV, Study type: Case Series.

Abstract The text proposes a reflection on the development of the didactic project "Narrate the experiences of alterity in the Education" tried in the discipline of Supervised Internship of the Course of Pedagogy of the FFP / UERJ. The objective of this project was to produce a didactic exercise of problematization on the ways of showing and looking at differences in education, mainly based on photographs produced by the students themselves in the pedagogical practice they develop in schools. The text is structured in four parts: the first presents the didactic project, the second presents considerations about the Supervised Internship as didactic space of experimentation, the third introduces a discussion about the ways of producing images of difference and, finally, we expose and discuss some photographs produced by future teachers.

Resumen El texto se propone una reflexión sobre el desarrollo del proyecto didáctico “Narrar las experiencias de alteridad en Educación” experimentado en la materia de Práctica Pedagógica de la Carrera de Pedagogía de la FFP/UERJ. El objetivo de este proyecto fue producir un ejercicio didáctico de problematización sobre las formas de mostrar y mirar las diferencias en educación, especialmente a partir de fotografías producidas por los propios alumnos en la práctica pedagógica que desarrollan en escuelas. El texto se estructura en cuatro partes: la primera presenta el proyecto didáctico, la segunda trae consideraciones sobre la Práctica Pedagógica como espacio didáctico de experimentación, la tercera introduce una discusión sobre las formas de producir imágenes de la diferencia y, finalmente, exponemos y discutimos algunas fotografías producidas por los futuros docentes.

Abstract BRS Sublime is a common bean cultivar with carioca grains, high nutritional grain quality, and high yield potential (4667 kg ha-1). It has a normal cycle, upright growth, low loss rates in the mechanical harvest, and is recommended for planting in 19 Brazilian states, in the three main common bean cultivation regions. It is the first cultivar developed in the world with angular leaf spot resistance.

Abstract Purpose: To evaluate the most frequent surgical techniques of high-risk colorectal anastomoses in rats. Methods: Wistar rats were enrolled in three different models comprising inflammatory (TNBS enema), vascular (portal vein occlusion) or obstructive (a non-ischemic constricting ring) mechanisms associated with colonic anastomosis that had accomplished after these former lesions. Histological analyses (Hematoxylin and eosin and Picrosirius red) were performed. Results: All anastomoses techniques were associated with risk factors and had complications, mainly anastomotic leakage. In Study 1, the use of a pharmacological agent, trinitrobenzene sulfonic acid (TNBS) mimicked an inflammatory bowel disease such as Crohn’s disease with 50% of anastomosis leakage, the higher percentage among all models tested. In Study 2, after portal ischemia followed by reperfusion it was observed a dense neutrophil infiltrate in the midst of necrotic tissue and fibrin at the anastomotic site and 5 days after the anastomosis, no collagen was produced. In Study 3, 5 days after the mechanical obstruction some denuded areas of epithelium with marked oedema of mucosa and submucosa were seen, at the anastomotic site and anastomosis group showed some reduction of collagen density when compared with Control/Sham group. Conclusion: All the experimental surgical techniques tested in rats were associated with high-risk colorectal anastomoses and were useful to study colonic anastomotic healing and intestinal leakage.

Estudou-se o efeito da inclusão de 0; 5; 10 e 15% de bagaço de mandioca, com base na matéria seca da dieta total de vacas mestiças Holandesas vs. Zebu, sobre a produção e composição do leite e sobre os impactos no custo da alimentação. Os animais estavam no terço médio de lactação e pesavam em média 478,5 kg. A dieta com 15% de bagaço de mandioca acrescentou 13,2% à produção, comparada à dieta controle. A conversão alimentar apresentou efeito quadrático com ponto mínimo em 4,2% de inclusão de bagaço de mandioca. A proteína bruta, único componente do leite que sofreu alteração, aumentou linearmente com os níveis de inclusão de bagaço de mandioca. O tratamento com 15% de bagaço de mandioca representou maior custo operacional efetivo (42,8% mais elevado em relação ao tratamento controle) e o maior ponto de nivelamento para a produção e preço do leite. Observaram-se os menores pontos de nivelamento para os tratamentos com 5 e 10% de inclusão de bagaço de mandioca, os quais apresentaram melhores resultados econômicos. O concentrado foi o principal responsável pela elevação dos custos, particularmente, quando ocorre a redução da razão volumoso : concentrado em função dos maiores teores de inclusão de bagaço de mandioca.

The addition of 0; 5; 10 and 15% cassava bagasse, based on the dry matter of the total diet of crossbred Holstein v. Zebu cows, was evaluated on milk production and composition and on the impacts of diet costs. The animals, weighing an average of 478.5 kg, were in the middle third lactation period. Diet with 15% cassava bagasse provided a 13.2% increase in production when compared to control. Feed conversion had a quadratic effect with minimum point at 4.2% of cassava bagasse inclusion. Crude protein, the only milk component that changed, increased linearly with the inclusion of cassava bagasse levels. Treatment with 15% cassava bagasse caused a more effective operational cost (42.8% higher when compared to control) and the highest leveling point for milk production and price. The lowest leveling points were treatments with 5 and 10% inclusion of cassava bagasse, which had the best economic results. Concentrates caused cost increase, particularly when roughage : concentrate ratio decreased due to higher cassava bagasse inclusion levels.

Este trabalho utiliza como corpus de análise os dados coletados pela equipe do Projeto Atlas Linguístico do Brasil em três regiões: Centro-Oeste, Sudeste e Sul. Os dados referem-se às cidades do interior e às capitais de cada estado, coletados junto a informantes selecionados segundo o perfil estabelecido. Nesta oportunidade, objetiva-se discutir a distribuição diatópica das variantes lexicais para a questão 132 - "Criança pequenininha, a gente diz que é bebê. E quando ela tem de 5 a 10 anos, do sexo masculino?" - do Questionário Semântico-Lexical (COMITÊ NACIONAL DO PROJETO ALIB, 2001). A metodologia utilizada envolveu análises descritivas e inferenciais pertinentes ao estudo. Para tanto, oito hipóteses foram testadas no sentido de averiguar o comportamento e a distribuição diatópica das cinco variantes mais produtivas no conjunto de respostas. Os principais resultados observados indicam que as variantes apresentam comportamento distinto nas três regiões: (i) a variante "menino" apresenta distribuição homogênea nos dez estados; (ii) as formas lexicais "guri" e "piá" possuem distribuição heterogênea na região Sul; (iii) as variantes de etimologia indígena ("guri" e "piá") são mais representativas nas regiões Sul e Centro-Oeste; (iv) há uma maior representatividade da variante "moleque" (étimo africano) na região Sudeste, principalmente em São Paulo e Minas Gerais.

BRS Esteio is a common bean cultivar with black grains of excellent cooking quality, suited for cultivation in 21 Brazilian States. In 77 trials of Value for Cultivation and Use, the cultivar had a normal cycle (90 days), an average yield of 2,529 kg ha-1, which is 8.1% higher than that of the control cultivars, a high yield potential (4,702 kg ha-1), upright growth, tolerance to lodging, and moderate resistance to anthracnose.