RESUMO As características de armazenamento das sementes contribuem para manter o diminuir a qualidade das mesmas. Neste pressuposto, o objetivo do estudo consistiu em analisar o efeito do frio durante vários períodos de tempo em 12 cultivares de feijão-preto. Para cada cultivar determinou-se o peso de 100 sementes armazenadas tanto em condição ambiental (27,22 °C e 62 % HR) quanto em frío (4,1°C e 13 % HR) durante 18 meses, nos quais se tomaram amostras ao início, 3, 6, 9, 12 e 18 meses para avaliar a porcentagem de germinação e plântulas anormais. Durante o armazenamento diminuiu a germinação e aumentaram as plântulas anormais. Identificaram-se diferenças entre as cultivares, das quais ‘Comapa’ tolera o armazenamento sob condições do trópico com somente 16,5 pontos porcentuais de redução, enquanto as cultivares ‘Veracruz’ e ‘Exp. 2’ registraram reduções de 50,5 e 40 pontos porcentuais, respectivamente.

Abstract The seed storage characteristics will contribute to maintaining or decreasing the quality of the seeds themselves. In this assumption, the objective of the study was to analyze the effect of cold during several periods of time in 12 black bean cultivars. The twelve black bean varieties were conditioned, the weight of 100 seeds was determined and they were stored under two conditions (27,22 ° C and 62 % HR) and refrigerated (4,1°C and 13 % HR) for 18 months, in which samples were taken at the beginning, 3, 6, 9, 12 and 18 months to evaluate the percentage of germination and abnormal seedlings. During storage, germination decreased and abnormal seedlings increased. Differences were identified among the varieties of which ‘Comapa’ tolerated storage under tropical conditions with only 16,5 percentage points of reduction while the ‘Veracruz’ and ‘Exp. 2’ varieties recorded reductions of 50,5 and 40 percentage points, respectively.

Abstract (Objective) This article presents a description and analysis of an educational experience with prospective primary school teachers, aimed at developing their skills to create proportionality problems by modifying an initial problem to reflect a didactic-mathematical orientation. (Methodology) This is a qualitative and interpretative investigation that adopted an engineering or design approach to teaching in its research methodology. Theoretical and methodological tools of the Onto-semiotic Approach were used in both the design of the experience, and in the content analysis of participants' responses. The investigation was carried out with a group of 127 Primary Education students of the University of Granada, Spain, organized in 33 teams to answer two problem-creation tasks. (Results) It was found that the participants most frequently created relevant problems by modifying a given problem, but that they did not manage to create problems that specifically allowed them to distinguish proportional from additive situations that are consistent with didactic-mathematical requirements. (Conclusions) Prospective teachers did not display sufficient didactic and mathematical knowledge to be able to successfully create proportionality problems. Training programs should therefore strengthen their strategies to develop this knowledge, incorporating it as a didactic resource in the teaching process to assist in improving the skills of prospective teachers in the analysis of mathematical activities.

Resumen (Objetivo) El objetivo de este artículo es describir y analizar una intervención formativa con futuro personal docente de primaria, dirigida a desarrollar la competencia para crear problemas de proporcionalidad mediante la variación de un problema inicial y la elaboración a partir de un requerimiento didáctico-matemático. (Metodología) Se trata de un estudio cualitativo e interpretativo que adopta una metodología propia de las investigaciones de diseño o ingeniería didáctica. Tanto en el diseño de la intervención, como en el análisis de contenido de las respuestas de los sujetos participantes se emplean herramientas teóricas y metodológicas del enfoque ontosemiótico. Se trabaja con un grupo de 127 estudiantes para docentes de Educación Primaria de la Universidad de Granada, España; organizados en 33 equipos para responder a dos consignas sobre creación de problemas. (Resultados) Los resultados muestran que los sujetos participantes crean con mayor frecuencia problemas pertinentes mediante la variación de un problema dado, pero que no logran crear problemas que permitan, de manera específica, distinguir situaciones proporcionales de aditivas a partir de un requerimiento didáctico-matemático. (Conclusiones) Se concluye que los futuros maestros y maestras manifiestan un conocimiento didáctico y matemático insuficiente para crear problemas de proporcionalidad exitosamente. Por esto es necesario que los programas de formación refuercen las estrategias para desarrollar esta tarea, incorporándola como recurso didáctico en el proceso de enseñanza, y mejorando la competencia para el análisis de la actividad matemática del futuro profesorado.

Resumo (Objetivo) Este artigo tem como objetivo descrever e analisar uma intervenção formativa com futuros professores do ensino básico, destinada a desenvolver a competência para criar problemas de proporcionalidade por variação de um problema inicial e elaboração com base num requisito didáticomatemático. (Metodologia) Este é um estudo qualitativo e interpretativo que adota uma metodologia própria das pesquisas de desenho ou engenharia didática. Tanto no desenho da intervenção como na análise de conteúdo das respostas dos sujeitos participantes são utilizados instrumentos teóricos e metodológicos da abordagem ontossemiótica. Trabalha-se com um grupo de 127 alunos para professores do Ensino Primário da Universidade de Granada, Espanha; organizados em 33 equipes para responder a duas instruções sobre a criação de problemas. (Resultados) Os resultados mostram que os sujeitos participantes criam com mais frequência problemas pertinentes ao variar um determinado problema, mas não conseguem criar problemas que permitam, de forma específica, distinguir situações proporcionais de aditivas a partir de uma exigência didático-matemática. (Conclusões) Conclui-se que os futuros professores apresentam conhecimentos didáticos e matemáticos insuficientes para criar com sucesso problemas de proporcionalidade. Por essa razão, é necessário que os programas de formação reforcem as estratégias para desenvolver esta tarefa, incorporando-a como recurso didático no processo de ensino e melhorando a competência para a análise da atividade matemática dos futuros professores.

Abstract Narcine entemedorandRhinoptera steindachneriare 2 viviparous batoid species of commercial importance on the Pacific coast of Mexico. However, no adequate management plan has been set forth for either of them to ensure sustainable use. The aims of this study were to assess the reproductive potential and the potential rate of population increase (rʹ) of both species, as well as contrasting their reproductive strategies, to infer how susceptible they are to fishing exploitation. Comparatively, among batoids,N. entemedorfemales have an early age at maturity, relatively high fecundity, and an intermediate lifespan, whileR. steindachnerifemales have an early age at maturity, low fecundity, and a relatively short lifespan. According to our estimates, however, both species have relatively high reproductive potential, whichN. entemedorexhibits by investing energy in maximizing fecundity andR. steindachneriby increasing the embryo’s body mass. Therefore,N. entemedorhas better capacity to recover from relatively high overfishing (rʹ = 0.48) in comparison withR. steindachneri(rʹ = -0.18). The methodology used in this study proved to be a good option to assess the risk of overfishing in species for which there is limited data.

Resumen Narcine entemedoryRhinoptera steindachnerison 2 especies de batoideos vivíparas de importancia comercial en la costa mexicana del Pacífico. Sin embargo, ninguna de las 2 cuenta con planes de manejo adecuados para asegurar su uso sustentable. Los objetivos de este estudio fueron evaluar el potencial reproductivo y la tasa potencial de aumento poblacional (rʹ) de ambas especies, así como contrastar sus estrategias reproductivas para inferir qué tan susceptibles son a la explotación pesquera. Comparativamente, entre los batoideos, las hembras deN. entemedortienen edad de madurez temprana, fecundidad relativamente alta y longevidad intermedia, mientras que las hembras deR. steindachneritienen edad de madurez temprana, fecundidad baja y longevidad relativamente corta. Sin embargo, de acuerdo con las estimaciones de este estudio, ambas especies tienen un potencial reproductivo relativamente alto,N. entemedora través de la inversión de energía para maximizar la fecundidad yR. steindachneria través del incremento de la masa corporal embrionaria. Por lo tanto,N. entemedortiene mejor capacidad para recuperarse de una sobrepesca relativamente alta (rʹ = 0.48) en comparación conR. steindachneri(rʹ = -0.18). La metodología utilizada en este estudio demostró ser una buena opción para evaluar el riesgo de sobrepesca en especies para las cuales los datos son limitados.

Abstract Background: Food craving is an intense-compulsive response to eating highly appetizing foods. The Food Cravings Questionnaire-State (FCQ-S) is the most used instrument for its diagnosis. It is a multidimensional instrument, sensitive and adaptable to contextual and cultural changes. Objective: To standardize the FCQ-S in the adult population of Mexico City. Method: Non-experimental, cross-sectional, at convenience design, with 1059 adults of both sexes, aged 18-84 years. It is highlighted that 71.9% of the participants were women. Results: A reliability coefficient of 0.95 was obtained, the correlations between the items were from r = 0.598 to r = 0.793. With the exploratory factorial analysis, an MKO of sampling adequacy of 0.943 was obtained, and with the Bartlett sphericity test a p = 0.000. The factors explain 78.61% of the total variation of the data. The RMSEA was 0.068, which indicates an acceptable fit. The CFI was 0.974, considered good, and NNFI was 0.969, good fit. The correlations ranged from p < 0.05 to p < 0.01, showing a connection between the different dimensions. Conclusions: The FCQ-S is valid and adaptable in the Mexican population.

Resumen Antecedentes: El food craving es un deseo intenso y compulsivo de comer alimentos altamente apetecibles. El Food Cravings Questionnaire-State (FCQ-S) es el instrumento más utilizado para su diagnóstico. Es un instrumento multidimensional, sensible y adaptable a cambios contextuales y culturales. Objetivo: estandarizar el FCQ-S en población adulta de la Ciudad de México. Método: Diseño no experimental, transversal y a conveniencia por método de bola de nieve, con 1059 adultos ambos sexos y de 18-84 años. Se destaca que el 71.9% de los participantes fueron mujeres. Resultados: Se obtuvo un coeficiente de fiabilidad de 0.95 y las correlaciones entre los ítems fueron de r = 0.598 a r = 0.793. Con el análisis factorial exploratorio se obtuvo una MKO de adecuación de muestreo de 0.943, y con la prueba de esfericidad de Bartlett una p = 0.000. Los factores explican el 78.61% de la variación total de los datos. La RMSEA fue 0.068, lo cual indica ajuste aceptable. El CFI fue 0.974, considerado bueno, y el NNFI fue 0.969 (buen ajuste). Las correlaciones fueron de p < 0.05 a p < 0.01, lo que muestra una conexión entre las diferentes dimensiones. Conclusiones: El FCQ-S es válido y adaptable en población mexicana.

Resumen Existe una gran cantidad de información sobre el tratamiento de apoyo farmacológico temprano para la rehabilitación posterior a un accidente cerebrovascular isquémico agudo. El objetivo de esta revisión es ofrecer a los profesionales de la salud involucrados en la rehabilitación de los pacientes un resumen de la evidencia disponible que colabore con la toma de decisiones en su práctica clínica diaria. Se realizó una búsqueda de ensayos clínicos aleatorizados y estudios observacionales publicados entre el 1/1/2000 y el 28/8/2022 utilizando como motor de búsqueda PubMed, Cochrane y Epistemonikos con restricción de idioma a ingles y español. Los estudios seleccionados incluyeron pacientes mayores de 18 años con un accidente cerebrovascular isquémico agudo sometidos a rehabilitación temprana. Los desenlaces considerados para eficacia fueron: función motora, lenguaje y dolor. Las intervenciones farmacológicas seleccionadas fueron: cerebrolisina, levodopa, selegilina, anfetaminas, fluoxetina, citalopram, escitalopram, antipsicóticos, memantine, pregabalina, amitriptilina y lamotrigina. Se realizó síntesis y evaluación de la evidencia utilizando metodología GRADE. Esta revisión proporcionó un resumen de evidencia sobre el tratamiento de apoyo farmacológico en la neuro-rehabilitación temprana de pacientes post accidente cerebrovascular isquémico agudo. Esto permitirá mejorar las recomendaciones actuales con el objetivo de colaborar con la toma de decisiones en salud para esta población.

Abstract There is a wealth of information on early pharmacological supportive treatment for early rehabilitation following acute ischemic stroke. This review aims to provide healthcare professionals involved in rehabilitating patients with a summary of the available evidence to assist with decision-making in their daily clinical practice. A search for randomized clinical trials and observational studies published between 1/1/2000 and 28/8/2022 was performed using PubMed, Cochrane and Epistemonikos as search engines with language restriction to english and spanish. The selected studies included patients older than 18 with acute ischemic stroke undergoing early rehabilitation. The outcomes considered for efficacy were: motor function, language, and central pain. The selected pharmacological interventions were: cerebrolysin, levodopa, selegiline, amphetamines, fluoxetine, citalopram, escitalopram, antipsychotics, memantine, pregabalin, amitriptyline and lamotrigine. Evidence synthesis and evaluation were performed using the GRADE methodology. This review provided a summary of the evidence on pharmacological supportive care in early rehabilitation of post-acute ischemic stroke patients. This will make it possible to improve current recommendations with the aim of collaborating with health decision-making for this population.

ABSTRACT This study focuses on critical thinking through the interpretation of statistical graphics and actions based on sustainability, from a classroom intervention in relation to the Water Crisis in the Biobío Region, Chile, to 165 students from 7th grade to the 4th year of a state establishment. The methodology is framed in a descriptive-qualitative ap- proach developed through a questionnaire focused on the interpretation of statistical graphs, decision-making, and their arguments. The results show that students point to the data used on the axis of the ordinates as the main difference between the two graphs and recognize how the appearance of the graph can change depending on the data used. The argument focuses on an unsupported level of demand and actions for sustainability focused on the personal, independent of the academic level or gender of the students.

RESUMEN Este estudio se centra en el pensamiento crítico desde la interpretación de gráficos esta- dísticos y las acciones basadas en la sostenibilidad, de una intervención de aula en relación con la Crisis Hídrica en la Región del Biobío, Chile, a 165 estudiantes de 7º básico a 4º año medio de un establecimiento estatal. La metodología se enmarca en un enfoque cualitativo descriptivo desarrollado por medio de un cuestionario centrado en la interpretación de gráficos estadísticos, la toma de decisiones y sus argumentos. Los resulta- dos evidencian que los estudiantes señalan los datos utilizados en el eje de las ordena- das como la principal diferencia entre los dos gráficos, y reconocen cómo la apariencia del gráfico puede cambiar dependiendo de los datos utilizados. La argumentación se concentra en un nivel de demanda sin respaldo y acciones para la sostenibilidad centradas en lo personal, independiente del nivel académico o el género de los estudiantes.

RESUMEN El gobierno corporativo nace ante la crisis de Wall Street, y crea la necesidad de que los tomadores de decisiones respondan a los accionistas por sus prácticas de negocio. A raíz de esto se elaboró un estudio cualitativo al sector cooperativista costarricense por medio de un muestreo de experto sobre los factores predominantes para la implementación de gobierno corporativo. Mediante la alternativa metodológica alcanzable, propuesta por Pablo Cáceres, se detectó que existe una diferenciación potestativa del legislador costarricense para supervisar los controles monetarios de las cooperativas, lo que implica una desventaja en cuanto a la presencia de estructura de regulación y fiscalización robustas y actualizadas.

RÉSUMÉ La gouvernance d'entreprise est née dans le sillage de la crise de Wall Street et crée la nécessité pour les décideurs de rendre compte aux actionnaires de leurs pratiques commerciales. C'est pourquoi une étude qualitative a été menée dans le secteur coopératif du Costa Rica, par le biais d'un échantillonnage d'experts, sur les facteurs prédominants de la mise en œuvre de la gouvernance d'entreprise. En utilisant l'alternative méthodologique viable proposée par Pablo Cáceres, il a été identifié qu'il existe une différenciation discrétionnaire du législateur costaricien pour superviser les contrôles monétaires des coopératives, ce qui implique un désavantage par rapport à la présence de structures de régulation et de supervision robustes et actualisées.

ABSTRACT Corporate governance emerged in response to the Wall Street crisis and created the need for decision-makers to be accountable to shareholders for their business practices. In light of this, a qualitative study was conducted on the Costa Rican cooperative sector through expert sampling to identify the predominant factors for implementing corporate governance. Using the feasible methodological alternative proposed by Pablo Cáceres, it was found that there is discretionary differentiation by the Costa Rican legislator in supervising the monetary controls of cooperatives. This implies a disadvantage in terms of the presence of robust and up-to-date regulatory and oversight structures.

RESUMO O governo corporativo nasce diante da crise de Wall Street e cria a necessidade de os tomadores de decisão responderem aos acionistas por suas práticas de negócio. Como resultado disso, foi realizado um estudo qualitativo sobre o setor cooperativista costarriquenho, por meio de uma amostragem de especialistas, sobre os fatores predominantes para a implementação do governo corporativo. Através da alternativa metodológica viável proposta por Pablo Cáceres, foi identificado que há uma diferenciação discricionária do legislador costarriquenho para supervisionar os controles monetários das cooperativas, o que implica uma desvantagem em relação à presença de estruturas de regulação e fiscalização robustas e atualizadas.

Resumen Introducción: La hipoglucemia hospitalaria (HH) es un problema importante ya que se vincula a muerte hospitalaria, estadía prolongada y mayores costos, en personas con y sin diabetes, en área crítica y sala general, sobre todo en los casos de hipoglucemia grave. El objetivo de nuestro trabajo fue comparar la mortalidad hospitalaria, pase a área crítica y tiempo de internación en adultos con HH, según la gravedad de la misma. Métodos: Se realizó un estudio de cohorte retrospectiva en pacientes adultos interna dos con hipoglucemia en el Hospital Italiano de Buenos Aires entre 2013 y 2018. Se definieron tres grupos de hipoglucemia: leve (glucemia entre 70 y 54 mg/dl), grave (glucemia < 54 mg/dl ≥ 40 mg/dl) y crítica (glucemia < 40mg/dl). Resultados: Un total de 5994 pacientes tuvieron HH, la mayoría presentó hipoglucemia leve (72%). La hipoglucemia grave y la crítica, comparadas con la hipoglucemia leve se asociaron a una mayor mortalidad: OR 2.6 (IC95% 2.2-3.1) y 4.2 (IC95% 3.5-5.0) respectivamente; y a mayor internación en áreas de cuidados críticos: OR 1.6 (IC95% 1.4-1.9) y 3.2 (IC95% 2.6-4.0) respectivamente. No hubo diferencias en el tiempo de internación. Discusión: Esta información aporta evidencia en nuestro país, sobre el valor pronóstico de la hipo glucemia, cuya mayor gravedad se asocia a mayor internación en áreas críticas y mayor mortalidad hospitalaria.

Abstract Background: Hospital hypoglycemia (HH) is an important problem since it is linked to hospital death, prolonged stay and higher costs, both in people with and without diabetes, in the critical area and general ward, especially in cases of severe hypoglycemia. The objective of our work was to compare hospital mortality, transfer to the critical area and hospitalization periods in adults with HH according to its severity. Methods: We conducted a retrospective cohort of adults hospitalized with hypoglycemia at the Hospital Italiano de Buenos Aires between 2013 and 2018. Three groups of hypoglycemia were defined: mild (glycemia between 70 and 54 mg/dl), severe (glycemia < 54 mg/dl and ≥ 40 mg/dl) and critical (glycemia<40mg/dl). Results: A total of 5994 patients had HH, the majority presented mild hypoglycemia (72%). Severe and critical hypoglycemia, compared with mild hypo glycemia, were associated with higher mortality: OR 2.6 (95%CI 2.2-3.1) and 4.2 (95%CI 3.5-5.0) respectively; and increased hospitalization in critical care areas: OR 1.6 (95%CI 1.4-1.9) and 3.2 (95%CI 2.6-4.0) respectively. There were no differences in length of stay. Discussion: This information provides, in our country, evidence on the prognostic value of hypoglycemia, whose greater severity is associated with increased hospitalization in critical areas and higher hospital mortality.

Abstract Objective: To estimate prevalence of diabetes in outpatient care and to describe its epidemiological characteristics, comorbidities, and related vascular complications. Methods: Observational cross-sectional study which included all adults affiliated from a private insurance health plan on March 2019, at Hospital Italiano de Buenos Aires, from Argentina. Results: The global prevalence of diabetes resulted in 8.5% with 95% CI 8.3-8.6 (12,832 out of a total of 150,725 affiliates). The age stratum with the highest prevalence was the group between 65 and 80 years old with 15.7% (95% CI 15.3-16.1). People with diabetes had a mean age of 70 years (SD 14), 52% were women, and the most frequently associated cardiovascular risk factors were: dyslipidaemia (88%), arterial hypertension (74%) and obesity (55%). In relation to metabolic control, 60% had at least one glycosylated hemoglobin measured in the last year, 70% of which were less than 7%. Almost 80% have LDL measured at least once in the last 2 years, 55% of them had an LDL value equal to or less than 100 mg/dl. The macrovascular complications present in order of frequency were: acute myocardial infarction (11%), cerebrovascular accident (8%) and peripheral vascular disease (4%); while the microvascular complications were found to be diabetic neuropathy (4%) and retinopathy (2%). 7% had diabetic foot, with less than 1% amputations. Conclusion: Diabetes represents a prevalent problem, even in elderly patients. This population continues to present a high cardiovascular risk, with little compliance with therapeutic goals.

Resumen Objetivo: Estimar la prevalencia de diabetes en atención ambulatoria y describir sus características epidemiológicas, comorbilidades y complicaciones vasculares relacionadas. Método: Corte transversal que incluyó la totalidad de adultos afiliados a la prepaga del Hospital Italiano de Buenos Aires en marzo de 2019, Argentina. Resultados: La prevalencia global de diabetes resultó del 8.5% con intervalo de confianza del 95% (IC95%): 8.3-8.6 (12,832 de un total de 150,725 afiliados). El estrato etario con mayor prevalencia fue el grupo entre 65 y 80 años, con un 15.7% (IC95%: 15.3-16.1). Las personas con diabetes presentaban una media de edad de 70 años (desviación estándar: 14), el 52% eran mujeres, y los factores de riesgo cardiovasculares más frecuentemente asociados fueron: dislipidemia (88%), hipertensión arterial (74%) y obesidad (55%). En relación con el control metabólico, el 60% tenía al menos una hemoglobina glucosilada medida en el último año, siendo el 70% de estas menores al 7%. Casi el 80% tiene medido el colesterol vinculado a lipoproteínas de baja densidad (c-LDL) al menos una vez en los últimos dos años, de ellos el 55% presentaba un valor de c-LDL igual o menor a 100 mg/dl. Las complicaciones macrovasculares presentes en orden de frecuencia fueron: infarto agudo de miocardio (11%), accidente cerebrovascular (8%) y enfermedad vascular periférica (4%); mientras que las complicaciones microvasculares resultaron ser neuropatía diabética (4%) y retinopatía (2%). El 7% tuvo pie diabético, con menos del 1% de amputaciones. Conclusiones: La diabetes representa un problema prevalente, incluso en pacientes ancianos. Esta población sigue presentando un elevado riesgo cardiovascular, con escaso cumplimiento de objetivos terapéuticos.

Resumen La intususcepción es una patología poco frecuente en adultos. Su presentación tiene una incidencia del 2 al 3% de las oclusiones que se presentan en pacientes adultos. El objetivo de este estudio es presentar una forma inusual de aparición de adenocarcinoma de colon, ya que en la gran mayoría de los casos inicia con dolor abdominal. Paciente de género femenino de 25 años, con antecedente familiar de cáncer, comienza con dolor abdominal súbito, náuseas y vómito; por estudios de imagen y hallazgos quirúrgicos intususcepción de colon ascendente, se aprecia presentación inusual en el cáncer de colon. La intususcepción debe hacer sospechar sobre una patología maligna, ya que es raro, y se debe realizar la historia clínica en busca de antecedentes oncológicos.

Abstract Intussusception is a rare pathology in adults. Its presentation has an incidence of 2 to 3% of the occlusions that occur in adult patients. The objective of this study is to present an unusual form of colon adenocarcinoma appearance, since in most of the cases starts with abdominal pain. A 25-year-old female patient, with a family history of cancer, began with sudden abdominal pain, nausea, and vomit; by imaging studies and surgical findings intussusception of the ascending colon, an unusual presentation in colon cancer can be seen. Intussusception should lead to suspicion of a malignant pathology, since it is rare, and a clinical history should be taken in search of an oncological history.

ABSTRACT BACKGROUND: Fat, muscle, and bone are endocrine organs capable of affecting the metabolic profile and cardiovascular risk. Relating these components is important to the establishment of early intervention strategies for overweight patients. AIMS: This study aimed to evaluate the influence of body mass components on the metabolic profile and cardiovascular risk in the preoperative period of bariatric surgery. METHODS: A cross-sectional study was conducted with patients admitted for bariatric surgery at a university hospital in the city of Recife, Brazil, between 2018 and 2019. Body composition was determined using dual-energy x-ray absorptiometry. Cardiovascular risk was assessed using the Framingham risk score. Data were collected on anthropometric, clinical, and lifestyle characteristics. The lipid profile (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides), blood glucose, and vitamin D were determined using the standard methods of the hospital laboratory. RESULTS: A total of 60 patients were analyzed, 86.7% of whom had comorbidities, 33.3% had moderate/high cardiovascular risk, and 71.4% had vitamin D insufficiency/deficiency. Lower lean body mass (adjusted PR 3.24; 95%CI 1.19–5.77) was independently associated with the severity of obesity. The body mass index and waist circumference were negatively correlated with lean body mass (r=-0.52; p<0.01)/r=-0.36; p<0.01). Lean body mass was negatively correlated with fat mass (r=-0.26; p<0.05), trunk fat (r=-0.29; p<0.05), fasting glucose (r=-0.26; p<0.05), and bone mineral density (r=-0.26; p<0.05). A total of 84.2% of individuals with less trunk fat tended to have low cardiovascular risk (p=0.05). However, physical inactivity (adjusted PR 2.14; 95%CI 1.19–5.54) and the risk of alcohol dependence (adjusted PR 2.41; 95%CI 1.76–4.15) were the only variables independently associated with cardiovascular risk. CONCLUSION: Obese patients in the preoperative period of bariatric surgery with less trunk fat tended to have low cardiovascular risk. However, the other components of body mass were also not associated with cardiovascular risk.

RESUMO RACIONAL: O tecido adiposo, músculos e ossos representam órgãos endócrinos, capazes de interferir no perfil metabólico e risco cardiovascular. Relacionar esses componentes será importante para estratégias de intervenção precoce, em obesos. OBJETIVOS: Avaliar a influência dos compartimentos da massa corporal, sobre o perfil metabólico e risco cardiovascular, no pré-operatório de cirurgia bariátrica. MÉTODOS: Estudo transversal, com pacientes admitidos para cirurgia bariátrica, em hospital universitário. A composição corporal foi avaliada pela absortometria radiológica de dupla energia e o risco cardiovascular pelo escore de risco de Framingham. Foram analisadas variáveis antropométricas, clínicas e de estilo de vida. Foi avaliado perfil lipídico (colesterol total, HDL-c, LDL-c, triglicerídeos), glicemia e vitamina D, utilizando a metodologia padrão. RESULTADOS: Foram analisados 60 pacientes, 86,7% apresentavam comorbidades, 33,3% risco cardiovascular moderado/elevado e 71,4% insuficiência/deficiência de vitamina D. Menor massa corporal magra associou-se à gravidade da obesidade. O índice de massa corpórea e a circunferência da cintura correlacionaram-se negativamente com a massa corporal magra (r=-0,52; p<0,01)/r=-0,36; p<0,01). A massa corporal magra correlacionou-se negativamente com a massa gorda (r=-0,26; p<0,05), gordura troncular (r=-0,29; p<0,05), glicemia de jejum (r=-0,26; p<0,05) e densidade mineral óssea (r=-0,26; p<0,05). Ao todo, 84,2% dos indivíduos com menos gordura troncular apresentaram tendência a baixo risco cardiovascular (p=0,05). Contudo, inatividade física (razão de prevalência ajustada 2,14; IC95% 1,19–5,54) e risco de dependência alcoólica foram as únicas variáveis independentemente associadas ao risco cardiovascular. CONCLUSÕES: Os pacientes obesos em pré-operatório de cirurgia bariátrica com menos gordura troncular, apresentaram tendência a baixo risco cadiovascular. Contudo, o risco cardiovascular também não foi associado aos demais componentes da massa corporal.

ABSTRACT Objective To identify the association between dietary patterns and nutritional status in adolescent freshmen at a public university in Northeastern Brazil. Methods In this cross-sectional study anthropometric variables, body composition and food intake were collected and assessed using the food frequency questionnaire. Dietary patterns were evaluated through factor analysis using the principal component extraction method. Results Two dietary patterns were identified: “Western” pattern, consisting of foods with high energy density and low nutritional value, and the “traditional Brazilian” pattern, with foods from Brazilian cuisine such as rice, beans, corn, roots and tubers, fruits, greens and vegetables. The multiple regression analysis revealed a negative association between the “traditional Brazilian” pattern and both excess weight and body fat in females. Conclusion A healthy dietary pattern with typical local cuisine foods can offer protection to health and should be encouraged.

RESUMO Objetivo Identificar a associação entre padrões alimentares e estado nutricional em adolescentes recém-ingressos em uma universidade pública do Nordeste brasileiro. Métodos Neste estudo transversal foram coletados dados antropométricos, composição corporal e consumo alimentar, verificado pelo questionário de frequência alimentar. Os padrões alimentares foram derivados através da análise fatorial pelo método de extração de componentes principais. Resultados Dois padrões alimentares foram identificados: o padrão “Ocidental”, composto por alimentos de elevada densidade energética e de baixo valor nutricional, e o padrão “tradicional brasileiro”, contendo alimentos da culinária brasileira como arroz, feijão, milho, raízes e tubérculos, frutas, verduras e legumes. A análise de regressão múltipla mostrou associação negativa entre o excesso de peso e de gordura corporal e o padrão alimentar “tradicional brasileiro” no sexo feminino. Conclusão Um padrão alimentar saudável e com alimentos típicos da culinária local pode conferir proteção à saúde, devendo ser incentivado.

Abstract Nucleotide excision repair pathway (NER) is an essential mechanism for single-strand breaks (SSB) repair while xeroderma pigmentosum family (XPA to XPG) is the most important system to NER. Myelodysplastic syndrome (MDS) is a heterogeneous hematological cancer characterized by cytopenias and risk of acute myeloid leukemia (AML) transformation. MDS pathogenesis has been associated with problems of DNA repair system. This report aimed to evaluate NER polymorphisms (XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) in 269 MDS patients of different populations in Latin America (173 Brazilian and 96 Argentinean). Genotypes were identified in DNA samples by RT-qPCR using TaqMan SNP Genotyping Assay. Regarding rs1799793 polymorphism of XPD for Brazilian population, the heterozygous genotype AG presented a high odds ratio (OR) to have a normal karyotype (p= 0.012, OR=3.000) and the mutant homozygous genotype AA was associated to a high OR of AML transformation (p= 0.034, OR=7.4). In Argentine population, the homozygous mutant AA genotype of rs1800975 polymorphism of XPA was associated with an increased odd to have hemoglobin levels below 8g/dL (p= 0.013, OR=10.000) while for the rs1799793 polymorphism of XPD, the heterozygous AG genotype decreased OR to be classified as good (p< 0.001, OR=9.05 × 10−10), and intermediate (p< 0.001, OR=3.08 × 10−10), according to Revised-International Prognostic Scoring System. Regarding the rs1800067 polymorphisms of XPF, the homozygous mutant AA genotype showed a decreased OR to be classified as good (p< 0.001, OR=4.03 × 10−13) and intermediate (p< 0.001, OR=2.54 × 10−13). Our report reinforces the heterogeneity of MDS and demonstrates the importance of ethnic differences and regional influences in pathogenesis and prognosis of MDS.