Pesquisa | SciELO

Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response.

https://doi.org/10.1016/j.abd.2023.03.002

Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
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Lomba, Guilherme Schittine Bezerra

; Silva, Pedro Henrique Abreu da

; Rosário, Natalia Fonseca do

; Medeiros, Thalia

; Alves, Lilian Santos

; Silva, Andrea Alice

; Almeida, Jorge Reis

; Lugon, Jocemir Ronaldo

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e1

Resumo: En | Texto: En | PDF: En

ABSTRACT In Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a six-month follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06, 95%CI 1.46 – 11.30) and longer hospital stay (HR 1.01, 95%CI 1.00 – 1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.

https://doi.org/10.1590/s1678-9946202466001

Tendência da taxa de mortalidade por câncer de mama em mulheres com 20 anos ou mais no Brasil, 2005-2019
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Silva, Gabriela Rodarte Pedroso da

; Guimarães, Rafael Alves

; Vieira, Flaviana Vely Mendonça

; Silva, George Oliveira

; Oliveira, Faétila dos Santos

; Aredes, Natália Del’ Angelo

Ciência & Saúde Coletiva

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2024, Volume 29 Nº 3 elocation e01712023

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The aim is to analyze the trend in breast cancer mortality rates and its correlation with the socioeconomic development status in Brazil. It involved an ecological time series study carried out in the 26 units of the federation, Federal District and regions of Brazil. Data sources included the Mortality Information System (number of deaths), the Brazilian Institute of Geography and Statistics (resident population) and the study of the Global Burden of Disease (Socio-demographic Index - SDI). Data from 2005 to 2019 were used. The trend was analyzed using Prais-Winsten regression models. The relationship between the mortality rate and the SDI was analyzed using Spearman’s correlation coefficient. During the study period, 207,683 deaths from breast cancer occurred. The average standardized mortality rate was 19.95 deaths per 100,000 women in Brazil. All the regions of Brazil showed an increasing trend in mortality. Of the total federative units, 22 showed an increasing trend. There was a positive relationship between the mortality rate and the SDI. The standardized mortality rate for breast cancer showed an increasing trend in Brazil, in all regions and in most states. There was a direct association between mortality and SDI, indicating a greater magnitude in more developed regions.

Resumo O objetivo é analisar a tendência da taxa de mortalidade por câncer de mama e sua correlação com o status de desenvolvimento socioeconômico no Brasil. Estudo ecológico de séries temporais realizado nos 26 estados, Distrito Federal e regiões do Brasil. As fontes de dados foram o Sistema de Informação sobre Mortalidade (número de óbitos), o Instituto Brasileiro de Geografia e Estatística (população residente) e o estudo da Carga Global de Doenças (socio-demographic index - SDI). Foram usados dados de 2005 a 2019. A tendência foi analisada pelos modelos de regressão de Prais-Winsten. A relação entre a taxa de mortalidade e o SDI foi analisada pelo coeficiente de correlação de Spearman. No período do estudo ocorrerem 207.683 óbitos por câncer de mama. A taxa padronizada de mortalidade média foi de 19,95 óbitos por 100.000 mulheres no Brasil. O Brasil e todas as regiões apresentaram tendência crescente da mortalidade. Do total de estados, 22 apresentaram tendência crescente. Verificou-se relação positiva entre a taxa de mortalidade e o SDI. A taxa de mortalidade padronizada por câncer de mama apresentou tendência crescente no Brasil, em todas as regiões e na maioria das unidades da federação. Verificou-se associação direta entre mortalidade e SDI, indicando maior magnitude em regiões mais desenvolvidas.

https://doi.org/10.1590/1413-81232024293.01712023

Nurseped: tecnología educativa para la seguridad en el manejo de antibióticos intravenosos en pediatría
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Alves, Amanda Paiva Bernardes

; Aredes, Natália Del’ Angelo

; Silva, George Oliveira

; Oliveira, Faétila dos Santos

; Fonseca, Luciana Mara Monti

; Ribeiro, Laiane Medeiros

Revista Latino-Americana de Enfermagem

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Dez 2023, Volume 31 elocation e4067

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Objective: to develop and validate the content of a serious game on the safe management of intravenous medications in pediatrics. Method: methodological study for the development and content validation of an educational technology. The cases and challenges of the serious game were developed based on a literature review and validated by 11 nurses with training and experience in the area. Content validity and agreement indices were adopted to analyze agreement and internal consistency (minimum of 0.8). Results: the content is based on the main antibiotics used in the clinical management of infections in hospitalized children and patient safety. Absolute agreement was obtained in 60 of the 61 items evaluated, and the minimum obtained was 0.82 in the content validation index and 0.80 in agreement. Adjustments were suggested by experts in the response statement for a specific case and implemented to improve the quality of the technology content. Conclusion: the content of the serious game Nurseped was validated by nurse experts in child health regarding clinical cases, question statements and multiple-choice answers, in addition to feedback that presents the user with an evidence-based answer after getting the challenge right or wrong.

Objetivo: desarrollar y validar el contenido de un serious game sobre el manejo seguro de medicamentos intravenosos en pediatría. Método: estudio metodológico para el desarrollo y validación de contenido de una tecnología educativa. Los casos y desafíos del serious game se basaron en una revisión de la literatura y fueron validados por 11 enfermeros con formación y experiencia en el área. Se adoptaron índices de validez de contenido y concordancia para el análisis de concordancia y consistencia interna (mínimo de 0,8). Resultados: el contenido se basa en los principales antibióticos utilizados en el manejo clínico de infecciones en niños hospitalizados y en la seguridad del paciente. Se obtuvo una concordancia absoluta en 60 de los 61 ítems evaluados, y el mínimo obtenido fue de 0,82 en el índice de validación de contenido y 0,80 en concordancia. Los expertos sugirieron ajustes en la formulación de respuestas de un caso específico y se implementaron para mejorar la calidad del contenido de la tecnología. Conclusión: el contenido del serious game Nurseped fue validado por enfermeros expertos en salud infantil en cuanto a casos clínicos, enunciados de preguntas y respuestas de opción múltiple, además del feedback que presenta al usuario una respuesta basada en evidencia tras acertar o fallar en el desafío.

Objetivo: desenvolver e validar o conteúdo de um serious game sobre o manejo seguro de medicamentos endovenosos em pediatria. Método: estudo metodológico para o desenvolvimento e validação de conteúdo de uma tecnologia educacional. Os casos e desafios do serious game foram desenvolvidos com base em revisão da literatura e validados por 11 enfermeiros com formação e atuação na área. Adotou-se os índices de validade de conteúdo e concordância, para análise de concordância e consistência interna (mínimo de 0,8). Resultados: o conteúdo é baseado nos principais antibióticos utilizados no manejo clínico de infecções em crianças hospitalizadas e na segurança do paciente. Obteve-se concordância absoluta em 60 dos 61 itens avaliados, o mínimo obtido foi 0,82 no índice de validação de conteúdo e 0,80 na concordância. Ajustes foram sugeridos pelos experts no enunciado de respostas de um caso específico e implementados para o aprimoramento da qualidade do conteúdo da tecnologia. Conclusão: o conteúdo do serious game Nurseped foi validado por enfermeiros experts em saúde da criança quanto aos casos clínicos, aos enunciados das perguntas e às respostas de múltipla escolha, além do feedback que apresenta ao usuário uma resposta baseada em evidências após o acerto ou erro do desafio.

https://doi.org/10.1590/1518-8345.6886.4067

Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis
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Assumpção, Natália Lombardi

; Araújo, Juliana Gusmão de

; Serra, Lucieny Silva Martins

; Ribeiro, Vanessa Veis

; Sampaio, Maria Luiza Queiroz

; Caram, Andressa Alves

; Sampaio, André Luiz Lopes

Brazilian Journal of Otorhinolaryngology

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Out 2023, Volume 89 Nº 5 elocation 101288

Resumo: En | Texto: En | PDF: En

Abstract Objectives: To determinate the otoprotective efficacy of melatonin.in experimental models of rodents through a systematic review of the literature. Methods: Altogether, 154 articles were found in four databases. The PICOS strategy (Population, Intervention, Comparison, and Outcome) was used to define the eligibility criteria. Studies that met the inclusion criteria for the second step were included in a qualitative synthesis. Each study type was analyzed with the CAMARADES quality of assessment’s checklist and the SYRCLE RoBS risk of bias. Results: Seven articles were selected, and four were included in the meta-analysis. It was possible to obtain seven outcomes according to the standard auditory frequencies presented among the studies, considering a minimum of three standard frequencies. The outcomes analyzed were for the frequencies of 1500, 2000, 3000, 4000, 5000, 6000, and 8000 Hz. Conclusion: Melatonin can provide protection against the ototoxic effects of cisplatin and aminoglycosides at 5000 Hz, 6000 Hz, and 8000 Hz, thereby minimizing the reduction in Otoacustic Emissions (OAE) amplitude. The same effect was not observed in the lower frequencies. Despite the limited number of studies that were evaluated, the results appeared consistent in higher frequencies. However, the methodology of the available studies did not meet the necessary methodological rigor that promotes the safe replicability of these studies.

https://doi.org/10.1016/j.bjorl.2023.101288

Body fat, cardiovascular risk factors and polymorphism in the FTO gene: randomized clinical trial and different physical exercise for adolescents
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Bila, Wendell C.

; Romano, Márcia C.C.

; Santos, Luciana L. dos

; Silva, Valmin R. da

; Capanema, Flavio D.

; Pfrimer, Karina

; Ferriolli, Eduardo

; Alves, Natália M.C.

; Campos, Cezenário G.

; Carlos, Fabiângelo M.

; Santos, Maria E.S.M. dos

; Lamounier, Joel A.

Jornal de Pediatria

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Abr 2023, Volume 99 Nº 2 Páginas 139 - 146

Resumo: En | Texto: En | PDF: En

Abstract Objective: To investigate the effects of different physical exercise programs and polymorphisms of the FTO (fat mass and obesity-associated gene) on body composition and cardiovascular risk factors in adolescents with overweight and obesity. Methods: A randomized, parallel, double-blind clinical trial consisting of the adolescent overweight from the state public network, in a simple representative random sample, who participated in an aerobic exercise or weight training intervention for 10 weeks. Anthropometry, body composition, biochemical markers, sexual maturation, and rs9939609 polymorphism in the FTO gene were assessed. 347 adolescents had their characterization of nutritional status. 72 individuals with overweight and obesity were invited to participate. 39 remained for the start of the program and were randomly allocated to both types of intervention. In the end, 26 subjects participated in the intervention programs, with 12 and 14 in the aerobic and weight training programs, respectively. Results: Heterozygous and homozygous bearers of risk allele A participating in the aerobic program showed improvements in glycemia (p = 0.002) and total cholesterol (p = 0.023) and a reduction in body fat mass (p = 0.041). The weight training program reduced glycemia in patients with the risk allele A (p = 0.027). Cameron’s stage four sexual maturation participants were 2.1 times more likely to improve their body fat (CI = 1.31–3.39). Conclusion: Aerobic exercises produced exclusively a significant decrease in fat mass and total cholesterol in patients with risk allele A. Distinct physical exercise programs may cause diverse changes in risk variables related to the health of adolescents.

https://doi.org/10.1016/j.jped.2022.07.004

Favorable Safety Experience of Local Dental Anesthesia in ICD Recipients with Cardiac Channelopathies
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Oliveira, Ana Carolina Guimarães

; Neves, Itamara Lucia Itagiba

; Sacilotto, Luciana

; Olivetti, Natália Quintella Sangiorgi

; Bueno, Savia Christina Pereira

; Pessente, Gabrielle D’Arezzo

; Santos-Paul, Marcela Alves dos

; Montano, Tânia Cristina Pedroso

; Carvalho, Cíntia Maria Alencar de

; Grupi, Cesar José

; Barbosa, Sílvio Alves

; Pastore, Carlos Alberto

; Samesima, Nelson

; Wu, Tan Chen

; Hachul, Denise Tessariol

; Scanavacca, Maurício Ibrahim

; Neves, Ricardo Simões

; Darrieux, Francisco Carlos da Costa

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20200312

Resumo: En | Texto: En | PDF: En

Abstract Background Dental anesthetic management in implantable cardioverter defibrillator (ICD) recipients with cardiac channelopathies (CCh) can be challenging due to the potential risk of life-threatening arrhythmias and appropriate ICD therapies during procedural time. Objectives The present study assessed the hypothesis that the use of local dental anesthesia with 2% lidocaine with 1:100,000 epinephrine or without a vasoconstrictor can be safe in selected ICD and CCh patients, not resulting in life-threatening events (LTE). Methods Restorative dental treatment under local dental anesthesia was made in two sessions, with a wash-out period of 7 days (cross-over trial), conducting with a 28h - Holter monitoring, and 12-lead electrocardiography, digital sphygmomanometry, and anxiety scale assessments in 3 time periods. Statistical analysis carried out the paired Student’s t test and the Wilcoxon signed-rank test. In all cases, a significance level of 5% was adopted. All patients were in stable condition with no recent events before dental care. Results Twenty-four consecutive procedures were performed in 12 patients (9 women, 3 men) with CCh and ICD: 7 (58.3%) had long QT syndrome (LQTS), 4 (33.3%) Brugada syndrome (BrS), and 1 (8.3%) Catecholaminergic polymorphic ventricular tachycardia (CPVT). Holter analysis showed no increased heart rate (HR) or sustained arrhythmias. Blood pressure (BP), electrocardiographic changes and anxiety measurement showed no statistically significant differences. No LTE occurred during dental treatment, regardless of the type of anesthesia. Conclusion Lidocaine administration, with or without epinephrine, can be safely used in selected CCh-ICD patients without LTE. These preliminary findings need to be confirmed in a larger population with ICD and CCh.

https://doi.org/10.36660/ijcs.20200312

Non-destructive determination of the oil content in peach palm (Bactris gasipaes) flour using NMR and NIR spectroscopies
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SANTOS, Yves José de Souza

; CAMPOS, Natalia Alves

; BICCA, Gerson Balbueno

; SORA, Gisele Teixeira de Souza

; POLESI, Luis Fernando

; ALBERTE, Tania Maria

; SANTOS, Poliana M.

; GARCIA, Rodrigo Henrique dos Santos

; COLNAGO, Luiz Alberto

; OLIVEIRA-FOLADOR, Gabrieli

Food Science and Technology

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2023, Volume 43 elocation e112322

Resumo: En | Texto: En | PDF: En

Abstract The oil from the fruit of peach palm or Pupunha (Bactris gasipaes) is an example of a material with low-cost and good antioxidant capacity. However, Conventional methods for measuring oil content are time-consuming, labor-intensive and use toxic chemicals. In this sense, the aim of this study was evaluated fast and non-destructive spectroscopy methods, such as Near Infrared (NIR) and Time-Domain Nuclear Magnetic Resonance (TD-NMR) (CPMG and ROSE pulse sequences), to quantify the oil content in pupunha flours collected in the amazon forest. For this, 93 samples were used and the results showed three distinct levels of oil in the samples: high, medium and low oil content. Furthermore, the determination coefficient (R2) reached values of 0.92, 0.92 and 0.70 for NIR, TD-NMR (ROSE) and TD-NMR (CPMG), respectively. Therefore, the NIR and TD-NMR (ROSE) methods demonstrate a higher prediction efficiency, with the NIR achieving 100% classification of the samples.

https://doi.org/10.1590/fst.112322

COVID-19 outcomes in people living with HIV: Peering through the waves
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Resumo: En | Texto: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.

https://doi.org/10.1016/j.clinsp.2023.100223

10.

Academics knowledge about tooth bleaching: technical and ethical issues
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FLOR-RIBEIRO, Mariana Dias

; RODRIGUES, Natalia Simora

; CASTRO, Fabricio Luscino Alves de

; BARCELLOS, Daphne Camara

; PAZINATTO, Flávia Bittencourt

RGO - Revista Gaúcha de Odontologia

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2023, Volume 71 elocation e20230059

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: The aim of this study was to evaluate the level of knowledge of UFES dental students about home bleaching treatment. Methods: As a methodology, a descriptive and cross-sectional study was carried out through the application of practice to 109 students, containing questions about home tooth whitening, technical care and possible complications of the treatment. Data were tabulated and submitted to descriptive statistics. Results: Of the total number of students, 88.99% said they knew the factors that limit or contraindicate the bleaching treatment, 16.51% of students recognize hydrogen peroxide as a possible inducer of oral cancer, 30.27% of the students had their teeth whitened inside the University, 44.03% had their teeth whitened outside the University without professional supervision. In addition, 56.88% believe anamnesis and clinical examination are necessary before the bleaching treatment. Conclusion: It is concluded that students have limited knowledge about certain points of at-home tooth whitening. Students know the risk factors of bleaching treatment, except regarding hydrogen peroxide being a possible inducer of oral cancer. It can be inferred that academics highlight the importance of associating the clinical examination with the patient’s anamnesis before performing the bleaching treatment. Most students have had their teeth whitened outside the University, which calls attention to reinforce knowledge about the ethical issues of the profession.

RESUMO Objetivo: O objetivo deste estudo foi avaliar o nível de conhecimento dos acadêmicos de odontologia da UFES sobre o tratamento clareador caseiro. Métodos: Como metodologia, foi realizado um estudo descritivo e transversal por meio da aplicação de questionário a 109 estudantes contendo perguntas sobre o clareamento dental caseiro, cuidados técnicos e possíveis riscos do tratamento. Os dados foram tabulados e submetudos à estatística descritiva. Resultados: Do total de estudantes, 88,99% disse conhecer os fatores que limitam ou contraindicam o tratamento clareador; 16,51% dos estudantes reconhecem o peróxido de hidrogênio como possível indutor de câncer bucal; 30,27% dos estudantes realizaram o clareamento dental dentro da Universidade, 44,03% realizaram o clareamento dental fora da Universidade sem supervisão profissional. Além disso, 56,88% acreditam que são necessários anamnese e exame clínico antes de realizar o tratamento clareador. Conclusão: Conclui-se que os alunos têm conhecimento limitado sobre determinados pontos do clareamento dental caseiro. Os estudantes conhecem os fatores de risco do tratamento clareador, exceto a respeito do peróxido de hidrogênio ser um possível indutor de câncer bucal. Pode-se inferir que os acadêmicos relevam a importância da associação do exame clínico com a anamnese do paciente antes de se realizar o tratamento clareador. A maioria dos estudantes tem realizado o clareamento dental fora da Universidade, o que chama atenção para reforçar o conhecimento sobre as questões éticas da profissão.

https://doi.org/10.1590/1981-86372023005920230013

11.

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

12.

Nitrous oxide emission from excreta of different beef cattle breeds finished in feedlot
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Teixeira, Natalia Pinheiro

; Oliveira, Alan Figueiredo de

; Menezes, Guilherme Lobato

; Alvarenga, Ramon Costa

; Campanha, Mônica Matoso

; Alves, Bruno José Rodrigues

; Lana, Ângela Maria Quintão

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03312

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The objective of this work was to compare nitrous oxide (N2O) emissions from urine and manure of Nellore and crossbred (Nellore x Angus) cattle finished in feedlot. Twenty Nellore and 20 crossbred bulls were fed a diet consisting of 75% concentrate and 25% roughage. Excreta were applied to the pens after 43 days of confinement, when N2O monitoring started through static chambers. The data were subjected to the analysis of variance, and averages were compared by Tukey’s test. The N2O fluxes from urine and manure were similar among the breeds, with important peaks after rain events. The cumulative emissions of N2O from urine per kilogram of body weight gain (BWG) and the total emissions from manure per kilogram of BWG were 22.7% and 24.4% higher in Nellore cattle. There is no breed effect on N2O flux and cumulative emissions by excreta from confined beef cattle; however, the crossbreed emits less per kilogram of BWG. There is a high correlation between rainfall volume and the N2O emissions of the next day, which indicates a period between rain occurrence and the increase in N2O emission.

Resumo O objetivo deste trabalho foi comparar as emissões de óxido nitroso (N2O) pela urina e pelas fezes de bovinos Nelore e mestiços (Nelore x Angus) terminados em confinamento. Vinte bois Nelore e 20 mestiços foram alimentados com dieta composta de 75% de concentrado e 25% de volumoso. As excretas foram aplicadas nos currais após 43 dias de confinamento, quando se iniciou o monitoramento de N2O por meio de câmaras estáticas. Os dados foram submetidos à análise de variância, e as médias foram comparadas pelo teste de Tukey. Os fluxos de N2O da urina e das fezes foram semelhantes entre as raças, com picos importantes após a ocorrência de chuvas. As emissões cumulativas de N2O da urina por quilograma de ganho de peso corporal (GPC) e as emissões totais das fezes por quilograma de GPC foram 22,7% e 24,4% maiores na raça Nelore. Não há efeito da raça sobre o fluxo de N2O e as emissões cumulativas de excretas de bovinos de corte confinados; entretanto, o gado mestiço emite menos por quilograma de GPC. Há alta correlação entre o volume de chuva e as emissões de N2O do dia seguinte, o que indica um período entre a ocorrência de chuva e o aumento da emissão de N2O.

https://doi.org/10.1590/s1678-3921.pab2023.v58.03312

13.

Silicon application for the production and quality of raspberry fruit in a subtropical region
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Silva, Alexandre Dias da

; Pio, Rafael

; Reis, Letícia Alves Carvalho

; Afridi, Muhammad Siddique

; Suárez, Natália Ferreira

; Peche, Pedro Maranha

; Ribeiro, Carlos Henrique Milagres

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03371

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The objective of this work was to evaluate the effect of silicon (Si) on the cultivation and quality of raspberries (Rubus idaeus). The experiment consisted of seven treatments and four blocks located in a subtropical region. Each plot consisted of three pots with one seedling of 'Batum' raspberry. In each pot, the treatment consisted of Si doses at 0, 50, 100, 200, 400, 800, or 1600 mg dm-3, which were applied to the soil 15 days after the transplanting of the seedlings. Field analyses were performed by measuring chlorophyll a and b, water potential, and production. Fruit were analyzed for color, firmness, respiratory rate, soluble solids, and pH. Fertilization with Si stimulates the increase of fruit number and of the raspberry production per plant. The Si application increases the fruit production and fruit firmness; however, it reduces the water potential and respiration rate.

Resumo O objetivo deste trabalho foi avaliar o efeito do silício (Si) sobre o cultivo e a qualidade de framboesa (Rubus idaeus). O experimento consistiu de sete tratamentos e quatro blocos em região de clima subtropical. Cada parcela foi composta de três vasos com uma muda da framboeseira 'Batum'. Em cada vaso, o tratamento consistiu de doses de Si a 0, 50, 100, 200, 400, 800 ou 1600 mg dm-3, que foram aplicadas ao solo 15 dias após o transplante das mudas. As análises de campo foram realizadas pela medição de clorofilas a e b, potencial hídrico e produção. Os frutos foram analisados quanto à cor, firmeza, taxa respiratória, sólidos solúveis e pH. A adubação com Si estimula o aumento do número de frutos e da produção de framboesa por planta. O silício promove o aumento da produção e a firmeza dos frutos, no entanto, reduz o potencial hídrico e a taxa de respiração.

https://doi.org/10.1590/s1678-3921.pab2023.v58.03371

14.

Molecular characterization and epidemiology of Toxoplasma gondii isolates from free-range chickens in the southwest region of Goiás: new genotypes
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Domann, Natália

; Rezende, Stéfanne Rodrigues

; Fleury, Amanda Cristina Corrêa

; Barbosa, Isa Marianny Ferreira Nascimento

; Ribeiro, Isabella da Costa

; Dornelas, Júlia Batista

; Oliveira, Tainá Francisca Cardoso de

; Moura, Vanessa Oliveira Lopes de

; Storchilo, Heloísa Ribeiro

; Castro, Ana Maria de

; Garcia, João Luís

; Cardoso, Ludimila Paula Vaz

; Rezende, Hanstter Hallison Alves

Revista Brasileira de Parasitologia Veterinária

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2023, Volume 32 Nº 4 elocation e009823

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The purpose of this study was to isolate Toxoplasma gondii from tissues of free-range chickens in the southwestern region of Goiás, to detect and molecularly characterize the genetic material of the parasite, and to determine the seroprevalence of the protozoan parasite in these animals. A seroprevalence of T. gondii antibodies of 76% (19/25) was found among the chickens, while genetic material from their tissues was detected in 56% (14/25). A total of 14 isolates was obtained in the bioassay, ten of which were considered acute, eight were considered isolates of high virulence lethal to mice, and four of low virulence, considered non-lethal but with the ability to chronify the infection. Seven of the ten isolates showed significant morphometric differences from the RH strain, in terms of nucleus-complex-apical distance, length and width. Genotyping of the acute isolates was performed by RFLP-PCR, using 11 genetic markers: SAG1, SAG2 (3’SAG2 and 5’SAG2), alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO. The results were compared and classified according to the genotypes listed on the ToxoDB Platform, where different profiles were observed indicating the presence of two known genotypes (#7 and #63) and five new genotypes (NEW 3, NEW4, NEW5, NEW6, NEW 7). The results showed high seroprevalence, isolation rate, molecular detection and genotypic variations of T. gondii in free-range chickens in the southwestern region of Goiás.

Resumo O objetivo deste estudo foi isolar Toxoplasma gondii de tecidos de galinhas caipiras da região sudoeste de Goiás, detectar e caracterizar molecularmente o material genético do parasito e determinar a soroprevalência do protozoário nestes animais. A soropositividade para anticorpos anti- T. gondii, nas galinhas caipiras, foi de 76% (19/25), enquanto a detecção do material genético dos tecidos foi de 56% (14/25). Por meio do bioensaio foi obtido um total de 14 isolados, sendo 10 agudos, dos quais oito foram considerados isolados de elevada virulência, sendo letais para camundongos; e quatro de baixa virulência, com capacidade de cronificar a infecção, considerados não letais. Em sete dos dez isolados foram identificadas diferenças morfométricas significativas em relação à cepa RH, quanto à distância núcleo-complexo apical, comprimento e largura. A genotipagem dos isolados agudos por RFLP-PCR foi realizada, utilizando-se 11 marcadores genéticos SAG1, SAG2 (3´SAG2 e 5´SAG2), alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, APICO. Os resultados foram comparados e classificados de acordo com os genótipos presentes na Plataforma ToxoDB, nos quais diferentes perfis foram observados indicando a presença de dois genótipos conhecidos (#7 e #63) e cinco genótipos novos (NEW 3, NEW4, NEW5, NEW6, NEW 7). Os resultados demonstraram elevada soroprevalência, taxa de isolamento, detecção molecular e variações genotípicas de T. gondii em galinhas caipiras da região sudoeste de Goiás.

https://doi.org/10.1590/s1984-29612023069

15.

A multilevel analysis model for dental caries determinants in independently-living elderly
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Branco, Natália Teixeira Tavares

; Ferreira, Raquel Conceição

; Souza, Jéssica Vancarla Rodrigues de

; Moreira, Allyson Nogueira

; Diniz, Ivana Márcia Alves

; Magalhães, Cláudia Silami

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e230692

Resumo: En | Texto: En | PDF: En

Aim To evaluate the prevalence of untreated caries and its association with biological, individual, and environmental variables in independently-living elderly people. Methods This cross-sectional study included 72 elderly (≥60 years) patients of a university dental clinic in Belo Horizonte, Brazil. Sociodemographic data, systemic diseases, medications, and free sugar intake were collected. Visible plaque, Decayed, Missing, and Filled Teeth (DMFT), and Decayed and Filled Root (DFR) indexes were assessed through clinical examination. Unstimulated saliva was collected to determine salivary flow, pH, and buffering capacity. Descriptive analysis and multilevel logistic regression analysis were performed following a dental caries theoretical model ( p <0.05, 95% CI). Results The mean DMFT and DFR were 24.44 (SD=4.59) and 3.21 (SD=2.93), respectively. The prevalence of untreated caries was 61.11%. In the adjusted multilevel regression model involving 1639 teeth, untreated dental caries was significantly associated with the presence of biofilm (OR = 1.84; 95% CI: 1.24–2.74), salivary buffering capacity (OR = 0.87; 95% CI: 0.77–0.99) and per capita income (OR = 0.06; 95% CI: 0.004–0.74). Conclusion The experience of dental caries was widespread among independently-living elderly patients, and its variability was best explained by the presence of biofilm, reduced salivary buffering capacity, and low per capita income. A comprehensive assessment is needed of the biological, individual, and environmental factors related to the presence of dental caries in independently-living elderly people.

https://doi.org/10.20396/bjos.v22i00.8670692

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