Resumo O objetivo do estudo foi avaliar a associação entre religiosidade e binge drinking no início da adolescência. Um estudo transversal realizado com adolescentes de 10 a 13 anos de Belo Horizonte, Brasil. Foi realizada uma amostragem aleatória estratificada considerando distrito administrativo e ano escolar. Os adolescentes preencheram um formulário com o AUDIT C, perguntas sobre religiosidade e perguntas sobre binge drinking pelos pais e melhor amigo. Um formulário sobre questões socioeconômicas foi respondido pelos responsáveis. Foi realizada análise descritiva, regressão logística univariada e multivariada. Participaram do estudo 650 adolescentes. A frequência de binge drinking foi de 13,7%. No modelo ajustado, a religiosidade não esteve associada ao binge drinking. As covariáveis associadas foram idade de 12-13 anos (OR: 1,94 IC95%: 1,06-3,56; p=0,030), binge drinking pela mãe (OR: 3,12; IC95%: 1,76-5,52; p<0,001) binge drinking pelo melhor amigo (OR: 6,01; IC95%: 3,40-10,62; p<0,001) e família não nuclear (OR: 1,80; IC95%: 1,01-3,23; p=0,045). Os achados revelaram que apesar dos adolescentes afirmarem serem religiosos, para o binge drinking, os principais fatores que influenciaram essa decisão foi o binge drinking pelo melhor amigo, mãe e família não nuclear.

Abstract This study evaluated the association between religiosity and binge drinking in early adolescence. A cross-sectional study was conducted with adolescents aged 10-13 from Belo Horizonte, Brazil. Stratified random sampling was performed considering the administrative district and school year. Adolescents filled an AUDIT-C form, containing questions about religiosity and binge drinking by parents and their best friends. Adolescents’ caregivers answered a form regarding socioeconomic issues. Descriptive analysis, univariate, and multivariate logistic regression were performed. A total of 650 adolescents participated in the study. The frequency of binge drinking was 13.7%. In the adjusted model, religiosity was not associated with binge drinking. The covariates associated were the age of 12-13 years (OR: 1.94; CI95%: 1.06-3.56; p=0.030), maternal binge drinking (OR: 3.12; CI95%: 1.76-5.52; p<0.001) best friend binge drinking (OR: 6.01; CI95%: 3.40-10.62; p<0.001) and nonnuclear family (OR: 1.80; CI95%: 1.01-3.23; p=0.045). The findings revealed that, for binge drinking, the main factors that influenced this decision were the best friend and maternal binge drinking and family structure, although the adolescents claimed to be religious.

Abstract This study evaluated the association between religiosity and binge drinking in early adolescence. A cross-sectional study was conducted with adolescents aged 10-13 from Belo Horizonte, Brazil. Stratified random sampling was performed considering the administrative district and school year. Adolescents filled an AUDIT-C form, containing questions about religiosity and binge drinking by parents and their best friends. Adolescents’ caregivers answered a form regarding socioeconomic issues. Descriptive analysis, univariate, and multivariate logistic regression were performed. A total of 650 adolescents participated in the study. The frequency of binge drinking was 13.7%. In the adjusted model, religiosity was not associated with binge drinking. The covariates associated were the age of 12-13 years (OR: 1.94; CI95%: 1.06-3.56; p=0.030), maternal binge drinking (OR: 3.12; CI95%: 1.76-5.52; p<0.001) best friend binge drinking (OR: 6.01; CI95%: 3.40-10.62; p<0.001) and nonnuclear family (OR: 1.80; CI95%: 1.01-3.23; p=0.045). The findings revealed that, for binge drinking, the main factors that influenced this decision were the best friend and maternal binge drinking and family structure, although the adolescents claimed to be religious.

Resumo O objetivo do estudo foi avaliar a associação entre religiosidade e binge drinking no início da adolescência. Um estudo transversal realizado com adolescentes de 10 a 13 anos de Belo Horizonte, Brasil. Foi realizada uma amostragem aleatória estratificada considerando distrito administrativo e ano escolar. Os adolescentes preencheram um formulário com o AUDIT C, perguntas sobre religiosidade e perguntas sobre binge drinking pelos pais e melhor amigo. Um formulário sobre questões socioeconômicas foi respondido pelos responsáveis. Foi realizada análise descritiva, regressão logística univariada e multivariada. Participaram do estudo 650 adolescentes. A frequência de binge drinking foi de 13,7%. No modelo ajustado, a religiosidade não esteve associada ao binge drinking. As covariáveis associadas foram idade de 12-13 anos (OR: 1,94 IC95%: 1,06-3,56; p=0,030), binge drinking pela mãe (OR: 3,12; IC95%: 1,76-5,52; p<0,001) binge drinking pelo melhor amigo (OR: 6,01; IC95%: 3,40-10,62; p<0,001) e família não nuclear (OR: 1,80; IC95%: 1,01-3,23; p=0,045). Os achados revelaram que apesar dos adolescentes afirmarem serem religiosos, para o binge drinking, os principais fatores que influenciaram essa decisão foi o binge drinking pelo melhor amigo, mãe e família não nuclear.

ABSTRACT Mucormycosis is a rare, sometimes severe fungal infection that has emerged as a possible complication of COVID-19. We report a case of a non-diabetic, apparently immunocompetent patient diagnosed with rhino-orbital-cerebral mucormycosis shortly after COVID-19 treatment with dexamethasone. The patient received optimized systemic antifungal therapy and extensive surgical treatment. So far, four months after the last hospital discharge, the patient has been in good general condition. This case is a dramatic reminder that beneficial corticosteroid therapy in general inevitably carries a risk of opportunistic infection, and corticosteroid therapy for COVID-19 risks orbital-rhinocerebral mucormycosis that clinicians should watch for with vigilance.

Abstract Objective To investigate Incidental Thyroid Carcinoma (ITC) by comparing the results of Fine Needle Aspiration Biopsy (FNAB) cytology and the postoperative pathological findings. Methods Data of 1479 patients who underwent total thyroidectomy were retrieved. Three hundred eighty-six patients were excluded due to insufficient data. Each surgical specimen studied received two histopathological diagnoses: the local diagnosis ‒ for the same area in which the FNAB was performed; and the final diagnosis, which includes a study of the entire surgical specimen. Results A thousand and ninety-three patients were investigated. FNAB result was malignant in 187 patients, benign in 204, suspicious or indeterminate in 668 cases, and inconclusive in 34 cases. The prevalence of ITC was 15.1%. Most of the ITC in this series was less than 0.5 cm. The incidence of ITC was higher in Bethesda III (17.5% ITC) and IV (19% ITC) than in Bethesda II cases (1.5% false negatives and 9% ITC). Conclusion Although the incidence of false-negative results in Bethesda II nodules is only 1.5%, 9% of these patients had ITC in the thyroid parenchyma outside the nodule that underwent preoperative FNAB. The incidence of ITC in the same scenario was even higher in Bethesda III (17.5%) and Bethesda IV cases (19%). Ultrasonography-guided FNAB is an excellent method for the assessment of thyroid nodules. However, biopsy sites should be carefully selected. Despite the high incidence of incidentalomas, total thyroidectomy should not always be the treatment of choice due to its rare but potentially serious complications. The findings of the present study can assist future clinical decisions towards active surveillance strategies for the management of papillary thyroid carcinoma.

Resumo Este estudo apresenta a formação do Arranjo Local da Penha, uma rede territorial comunitária criada em 2016, no complexo de favelas da Penha, Zona Norte da cidade do Rio de Janeiro. Protagonizada essencialmente por mulheres e voltada à promoção da agricultura urbana (ancorada nas bases da agroecologia), a rede se constrói a partir de articulações locais. Por meio da inserção em campo e observação participante, foi possível compreender as práticas dessa articulação em rede, analisando temas geradores, tais como: 1. mulheres e agroecologia, 2. saúde e 3. alimentação saudável. A partir deste território, será apresentada uma descrição da trajetória do Arranjo e os limites e as possibilidades de mobilização e desenvolvimento da agricultura urbana. Como resultados do Arranjo, observa-se a promoção do protagonismo das mulheres e a construção dos laços afetivos entre elas e o lugar, principalmente ao possibilitar o acesso à “comida de verdade” na favela. Destacamos, portanto, a importância desta experiência de mobilização territorial que parte do cuidado feminino com o entorno da casa, sendo a produção local de alimentos o caminho para se alcançar resgates de memória, a promoção da saúde e uma nova relação de percepção e potencialização do senso de pertencimento das moradoras.

Abstract This paper studies the development of Arranjo Local da Penha, a territorial community network created in 2016 in the favelas of Penha, rooted in the north zone of Rio de Janeiro. This network is led mostly by women practicing urban agriculture based on agroecology, who build and expand their project through local organization. Through field research and participant observation, the paper sheds new light on the practices and dynamics of this network. The paper describes the Arranjo’s trajectory, pointing out the limits and possibilities to the development of urban agriculture in the favelas of Penha. Overall, this research indicates an increase in women’s protagonistic role, in parallel to the building of strong emotional ties between Penha´s territory and them. These are outcomes of their effort to create access to “comida de verdade” (“real food”) in the favelas. The paper reinforces the importance of local food production as a path to promote not only health and well-being, but also the debates about memory and culture - leading to the strengthening of people´s social ties and their sense of belonging to the community.

ABSTRACT Objective: to build and validate an educational booklet for the breastfeeding support room. Methods: methodological study carried out in three stages: bibliographic survey, preparation of educational material and validation by specialist referees. The material structure regarding the sequence of information, design, illustrations, colors and diagramming was made by a specialized professional. Results: the final production resulted in the booklet entitled: “I went back to work, how am I going to breastfeed?”. Nine specialist referees in the area participated in the validation, evaluating the aspects: “content” and “scientific accuracy” validated from the CVI calculation, with an average of 0.81, following the cut indicated by the literature considering these items validated for “appearance”. The level of agreement between specialist was considered to vary between 86.8 and 97.6%, with the minimum established being 75%, validating this aspect. Conclusion: the objective of building and validating an educational technology aimed at the breastfeeding room, pioneer in this specific focus, was achieved.

RESUMEN Objetivo: construir y validar un folleto educativo para la sala de apoyo a la lactancia materna. Métodos: estudio metodológico realizado en tres etapas: encuesta bibliográfica, preparación de material educativo y validación por jueces expertos. La estructura del material, en cuanto a la secuencia de información, diseño, ilustraciones, colores y diagramación, fue realizada por un profesional especializado. Resultados: la producción final resultó en el folleto titulado: "He vuelto a trabajar, ¿cómo haré para amamantar?". Nueve jueces expertos en el área participaron en la validación, evaluando los aspectos: "contenido" y "precisión científica" validados a partir del cálculo del IVC, con un promedio de 0.81, siguiendo el corte indicado por la literatura considerando estos elementos validados para "apariencia". Se consideró que el nivel de acuerdo entre expertos variaba entre 86.8 y 97.6%, con un mínimo establecido de 75%, validando este aspecto. Conclusión: se logró el objetivo de construir y validar una tecnología educativa dirigida a la sala de lactancia, pionera en este enfoque específico.

RESUMO Objetivo: construir e validar uma cartilha educativa para a sala de apoio à amamentação. Métodos: estudo metodológico realizado em três etapas: levantamento bibliográfico, elaboração do material educativo e validação por juízes especialistas. A estrutura do material quanto à sequência das informações, design, ilustrações, cores e diagramação foi feita por profissional especializado. Resultados: a produção final resultou na cartilha intitulada: “Voltei a trabalhar, como vou amamentar?”. Participaram da validação nove juízes especialistas na área, avaliando os aspectos: “conteúdo” e “exatidão científica” validados a partir do cálculo do IVC, com média de 0,81, seguindo corte indicado pela literatura considerando esses itens validados para “aparência”. Considerou-se nível de concordância entre os especialistas variando entre 86,8 e 97,6%, sendo o mínimo estabelecido de 75%, validando esse aspecto. Conclusão: o objetivo de construir e validar uma tecnologia educativa voltada para a sala de amamentação, pioneira neste enfoque específico, foi alcançado.

Resumo O propósito deste trabalho é discutir os problemas da idealização da maternidade em teorias psicanalíticas. Adotamos o livro The Reproduction of Mothering como objeto para análise em função de sua repercussão histórica na psicanálise e no feminismo, bem como pela fundamentação teórica utilizada também em recentes estudos psicanalíticos sobre a maternidade. O estudo permitiu evidenciar que, mesmo partindo de uma perspectiva feminista, o livro analisado reproduz a idealização da maternidade, não considerando as ambivalências presentes no cuidado de crianças, nem a possibilidade de mulheres não terem desejo de maternar. A hipótese trabalhada é a de que a perspectiva psicanalítica que dá base para as formulações da autora facilita a prescrição sobre quem pode ou não exercer o cuidado e a reduzir a importância do universo social e desejante de quem cuida. A psicanálise de Jean Laplanche é apresentada como alternativa potencialmente mais aberta para a diversidade presente no cuidado de crianças. Pretendemos com este trabalho evidenciar a necessidade do contínuo debate entre psicanálise e perspectivas de crítica social, como o feminismo, bem como instigar a problematização dos pressupostos das teorias psicanalíticas que se propõe atualmente a discutir os temas da maternidade e do cuidado de crianças.

Abstract The aim of this paper is to discuss the problems of maternity idealization present in psychoanalytical theories. We adopt the book The Reproduction of Mothering as analysis’ object because of its historical repercussion in psychoanalysis and feminism, as well as because of its theoretical reasoning also used in recent psychoanalytical studies about maternity. The paper allowed to show that, even starting from a feminist perspective, the analyzed book reproduces the idealization of maternity, not considering the ambivalences present in children care, not even the possibility of women not desiring to be mothers. The hypothesis worked through is that the psychoanalytical perspective that lays the foundation for the author’s formulations facilitates the prescription about who can or cannot exercise the care and to reduce the importance of the social and desiring universe of the person who cares. Jean Laplanche’s psychoanalysis is presented as a potentially more open alternative to diversity present in children care. We intend with this paper to show the necessity of continuous debate between psychoanalysis and social critic perspectives, as feminism, as well as to instigate the problematization of purposes of psychoanalytical theories that presently propose to discuss themes about maternity and children care.

Resumen El propósito de este trabajo es discutir los problemas de la idealización de la maternidad en teorías psicoanalíticas. Adoptamos el libro The Reproduction of Mothering como objeto para análisis en función de su repercusión histórica en el psicoanálisis y en el feminismo, así como por la fundamentación teórica utilizada también en recientes estudios psicoanalíticos sobre la maternidad. El estudio permitió evidenciar que, aunque partiendo de una perspectiva feminista, el libro analizado reproduce la idealización de la maternidad, no considerando las ambivalencias presentes en el cuidado infantil, ni la posibilidad de que mujeres no tengan deseo de maternizar. La hipótesis trabajada es la de que la perspectiva psicoanalítica que da base para las formulaciones de la autora facilita la prescripción sobre quien puede o no ejercer el cuidado y a reducir la importancia del universo social y deseante de quien cuida. El psicoanálisis de Jean Laplanche se presenta como alternativa potencialmente más abierta para la diversidad presente en el cuidado infantil. Pretendemos con este trabajo evidenciar la necesidad del continuo debate entre el psicoanálisis y las perspectivas de la crítica social, como el feminismo, así como instigar la problematización de los supuestos de las teorías psicoanalíticas que actualmente se proponen a discutir los temas de la maternidad y del cuidado infantil.

RESUMO Objetivou-se avaliar no presente trabalho a digestibilidade in vitro de nutrientes de diferentes dietas com a adição de quitosana (Q), líquido da casca da castanha de caju (LCC) e a associação entre Q e LCC. Os tratamentos utilizados foram constituídos de 4 dietas (relação volumoso:concentrado, 100:0, 50:50, 40:60 e 20:80) associadas com 4 aditivos (controle, quitosana, LCC e a associação entre ambos Q+LCCt), totalizando 16 tratamentos,distribuídas em delineamento em blocos ao acaso em esquema fatorial 4x4. As dosagens utilizadas foram: Controle (sem adição de aditivos), LCC (600mg/Kg de MS), Quitosana (900mg/Kg de MS), e o LCCQ (600mg/Kg de MS de LCC + 900mg/Kg de MS de quitosana). No laboratório foram avaliados a DIVMS, DIVFDN, DIVPB, pH e NAR (nitrogênio amoniacal ruminal). Para as análises de pH e NAR, foram coletadas amostras nas horas 0, 2, 4, 6 e 8 após a incubação. Os resultados encontrados mostraram maior digestibilidade de MS, FDN e PB para dietas que receberam quitosana e líquido da casca da castanha de caju de forma isolada e maiores valores de pH e NAR nas dietas que receberam os dois aditivos associados. Conclui-se que a associação dos aditivos traz melhores resultados para a nutrição animal e eleva a produtividade dos ruminantes.

ABSTRACT This study evaluated the in vitro digestibility of nutrients from different diets added with chitosan (Q), technic cashew nut shell liquid (LCC) and the association of Q and LCC. The treatments used consisted of 4 diets (forage: concentrate ratio of 100: 0, 50:50, 40:60 and 20:80) associated with 4 additives (control, chitosan, LCC and the association of Q + LCC), totaling 16 treatments, in a 4x4 factorial randomized block design. The dosages used were: Control (without additives), LCC (600mg/kg DM), Chitosan (900mg/kg DM), and LCCQ (600mg/kg LCC DM + 900mg/kg Chitosan DM). In the laboratory, samples were analyzed for IVDMD, IVNDFD, IVCPD, pH and RAN (ruminal ammonia nitrogen). For pH and RAN analyses, samples were taken at 0, 2, 4, 6 and 8 hours after incubation. The results showed higher digestibility of DM, NDF and CP for diets with chitosan and technic cashew nut shell liquid alone and higher pH and RAN values in the diets containing the two additives. The association of additives brings better results for animal nutrition and increases ruminant productivity.

RESUMO: Introdução: A hormonioterapia no câncer de mama é fundamental para a transição do tratamento ativo aos cuidados de sobrevivência, pois melhora significativamente os resultados de sobrevida em longo prazo, além de propiciar melhor qualidade de vida e reduzir os custos de hospitalização. Porém, para atingir resultados desejáveis, são importantes a adesão e a persistência no tratamento recomendado. Metodologia: Estudo de coorte retrospectivo com 182 mulheres em tratamento hormonal identificadas em unidade oncológica de alta complexidade da Região Sudeste do Brasil e acompanhadas até 2014. Foram realizadas análise bivariada, para investigar os fatores associados à adesão, e regressão multivariada de Cox, para identificar variáveis associadas à descontinuidade do tratamento ao longo do tempo. Resultados: A adesão geral foi de 85,2% e a persistência, de 45,4% após 5 anos. Não foi encontrada associação entre as variáveis independentes estudadas e a adesão. Mulheres com estadiamento avançado (hazard ratio - HR = 2,24; intervalo de confiança de 95% - IC95% 1,45 - 3,45), que não realizaram cirurgia (HR = 3,46; IC95% 2,00 - 5,97) e com 3 ou mais internações hospitalares (HR = 6,06; IC95% 2,53 - 14,54) exibiram maior risco de descontinuidade. Discussão: As variáveis associadas à persistência refletem a relação entre a maior gravidade da doença e a interrupção do tratamento hormonal adjuvante. Conclusão: Apesar da alta adesão, observa-se aumento progressivo do número de pacientes que não persistem no tratamento, devido a características relacionadas à gravidade da doença, contribuindo para uma resposta terapêutica inadequada.

ABSTRACT: Introduction: Hormonal therapy in breast cancer is essential to the transition from active treatment to care survival, because it improves long-term survival and provides a better quality of life. reducing hospital costs as well. However, adherence and persistence in the recommended treatment are important to achieve the desirable results. Methodology: This is a cohort retrospective study of 182 women on hormonal treatment identified at a high complexity oncology unit, in the southeastern region of Brazil, and followed-up until 2014. We performed a bivariate analysis to analyze the factors associated with adherence and we conducted the multivariate Cox regression to identify variables associated with discontinuity of treatment over time. Results: Overall adherence was 85.2% and persistence was 45.4% at the end of 5 years. No association was found between the studied independent variables and adherence. Women with advanced stage (HR = 2.24; 95% confidence interval 1.45 - 3.45), who did not undergo surgery (HR = 3.46; 95%CI 2.00 - 5.97), and with three or more hospitalizations (HR = 6.06; 95%CI 2.53 - 14.54) exhibited increased risk of discontinuity. Discussion: The variables associated with persistence reflect the relation between the highest disease severity and the discontinuity of adjuvant hormonal treatment. Conclusion: Despite the high adherence level, there is a progressive increase in non-persistence among women on hormonal therapy, influenced by characteristics related to disease severity, which contributes to an inadequate therapeutic response.

RESUMO: Introdução: A hormonioterapia no câncer de mama é fundamental para a transição do tratamento ativo aos cuidados de sobrevivência, pois melhora significativamente os resultados de sobrevida em longo prazo, além de propiciar melhor qualidade de vida e reduzir os custos de hospitalização. Porém, para atingir resultados desejáveis, são importantes a adesão e a persistência no tratamento recomendado. Metodologia: Estudo de coorte retrospectivo com 182 mulheres em tratamento hormonal identificadas em unidade oncológica de alta complexidade da Região Sudeste do Brasil e acompanhadas até 2014. Foram realizadas análise bivariada, para investigar os fatores associados à adesão, e regressão multivariada de Cox, para identificar variáveis associadas à descontinuidade do tratamento ao longo do tempo. Resultados: A adesão geral foi de 85,2% e a persistência, de 45,4% após 5 anos. Não foi encontrada associação entre as variáveis independentes estudadas e a adesão. Mulheres com estadiamento avançado (hazard ratio - HR = 2,24; intervalo de confiança de 95% - IC95% 1,45 - 3,45), que não realizaram cirurgia (HR = 3,46; IC95% 2,00 - 5,97) e com 3 ou mais internações hospitalares (HR = 6,06; IC95% 2,53 - 14,54) exibiram maior risco de descontinuidade. Discussão: As variáveis associadas à persistência refletem a relação entre a maior gravidade da doença e a interrupção do tratamento hormonal adjuvante. Conclusão: Apesar da alta adesão, observa-se aumento progressivo do número de pacientes que não persistem no tratamento, devido a características relacionadas à gravidade da doença, contribuindo para uma resposta terapêutica inadequada.

ABSTRACT: Introduction: Hormonal therapy in breast cancer is essential to the transition from active treatment to care survival, because it improves long-term survival and provides a better quality of life. reducing hospital costs as well. However, adherence and persistence in the recommended treatment are important to achieve the desirable results. Methodology: This is a cohort retrospective study of 182 women on hormonal treatment identified at a high complexity oncology unit, in the southeastern region of Brazil, and followed-up until 2014. We performed a bivariate analysis to analyze the factors associated with adherence and we conducted the multivariate Cox regression to identify variables associated with discontinuity of treatment over time. Results: Overall adherence was 85.2% and persistence was 45.4% at the end of 5 years. No association was found between the studied independent variables and adherence. Women with advanced stage (HR = 2.24; 95% confidence interval 1.45 - 3.45), who did not undergo surgery (HR = 3.46; 95%CI 2.00 - 5.97), and with three or more hospitalizations (HR = 6.06; 95%CI 2.53 - 14.54) exhibited increased risk of discontinuity. Discussion: The variables associated with persistence reflect the relation between the highest disease severity and the discontinuity of adjuvant hormonal treatment. Conclusion: Despite the high adherence level, there is a progressive increase in non-persistence among women on hormonal therapy, influenced by characteristics related to disease severity, which contributes to an inadequate therapeutic response.

RESUMO: A expressão gênica de ErbB1 e ErbB2 e a imunomarcação de EGFR (Her1) e Her2 (c-erbB-2) foram avaliadas para verificar o envolvimento desses receptores em lesões pré-malignas e malignas da próstata canina, como a atrofia proliferativa inflamatória (PIA) e o carcinoma prostático (PC). Em relação à intensidade de imunomarcação para EGFR, não houve diferença entre o tecido prostático normal e com PIA e PC. Em relação a Her2, observou-se diferença de imunomarcação entre o tecido prostático normal e aqueles com PIA e PC e entre os com PIA e PC. Não houve correlação entre EGFR e Her2. O gene ErbB1 foi detectado em duas amostras normais, uma de PIA e em todas as amostras de PC. O gene ErbB2 foi detectado em duas amostras de PIA e em todas as amostras de PC, não sendo detectado no tecido prostático normal. Conclui-se que EGFR e Her2 atuam nas lesões de PIA e PC, sugerindo o envolvimento destes na carcinogênese da próstata canina.

ABSTRACT: Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in one with PIA, and in all samples with PC. ErbB2 mRNA was recorded in two canine samples with PIA, in all with PC, but was not detected in normal prostatic tissue. It was concluded that EGFR and Her2 play roles in canine PIA and PC, suggesting that those receptors may be involved in canine prostatic carcinogenesis.

ABSTRACT Objective This study aims to compare the prevalence of laryngopharyngeal reflux signs between two groups of patients undergoing thyroidectomy for voluminous goiter: substernal goiters and voluminous cervical goiter without thoracic extension. Subjects and methods A retrospective case-control study was performed with data retrieved of the charts of the patients submitted to thyroidectomies occurred at a tertiary care center (Head and Neck Surgery Department, University of São Paulo Medical School) between 2010 and 2014. The selected thyroidectomies were allocated in two groups for study: patients with substernal goiters and patients with voluminous cervical goiter without thoracic extension. Cervical goiters were selected by ultrasonography mensuration. Clinical criterion was used to define substernal goiter. Results The average thyroid volume in patients with substernal goiter was significantly greater than the average volume in patients with only cervical goiter (p < 0.001). The prevalence of signs of reflux laryngitis at laryngoscopy was significantly greater in substernal goiter patients (p = 0.036). Moreover, substernal goiter was considered as the unique independent variable for high reflux laryngitis signs at laryngoscopy (OR = 2.75; CI95%: 1.05-7.20; p = 0.039) when compared to only cervical goiter patients. Conclusion This study shows a significant association between substernal goiters and signs of laryngopharyngeal reflux at preoperative laryngoscopy. Therefore, when compared with voluminous cervical goiters, the substernal goiters increase the chance of reflux laryngitis signs in patients.

ABSTRACT Mining is an important economic activity. However, its impact on environment must be accessed, mainly on relevant processes for their sustainability. The objective of this study was to evaluate the diversity and efficiency of symbiotic nitrogen fixing bacterial communities in soils under different types of vegetation in the Quadrilátero Ferrífero: ironstone outcrops, Atlantic Forest, neotropical savanna, and a rehabilitated area revegetated with grass. Suspensions of soil samples collected under each type of vegetation were made in a saline solution to capture rhizobia communities that were then inoculated on cowpea [Vigna unguiculata (L.) Walp.], which was used as a trap plant. The symbiotic efficiency of the communities was evaluated in a greenhouse experiment and the data obtained were correlated to the chemical and physical properties of the soils under each type of vegetation. At the end of the experiment, the bacteria present in the nodules were isolated to evaluate their diversity. The highest numbers of nodules occurred in the treatment inoculated with soil samples from rehabilitated area revegetated with grass and neotropical savanna vegetation, and the lowest numbers were observed in the treatment inoculated with soil samples from ironstone outcrops and Atlantic Forest. In relation to root dry matter, the treatment inoculated with soil samples from Neotropical savanah was superior to those inoculated with soil samples from the other areas; already, in relation to the shoot dry matter, no significant difference among the treatments was observed. The soil properties with the greatest influence on the microbial communities were Al3+ content, considered as high in the Atlantic Forest and neotropical savanna vegetation, as intermediate in the iron outcrops, and as very low in the rehabilitated area revegetated with grass; organic matter, considered as very high in the ironstone outcrops and neotropical savanna, as high in the Atlantic Forest, and as low in the rehabilitated area revegetated with grass; and the pH, with intermediate acidity level in the rehabilitated area revegetated with grass, high level of acidity in the iron outcrops and neotropical savanna, and very high acidity in the Atlantic Forest. After isolation of the nodules, 380 bacterial strains were obtained and separated into 27 groups by cultural characterization analysis. Genetic diversity was evaluated by the 16S rRNA gene partial sequencing of 156 strains, which identified some bacteria belonging to nitrogen-fixing Leguminosae nodulating bacterial genera (Rhizobium, Bradyrhizobium, Burkholderia, and Cupriavidus), some representative of associative bacteria (Bacillus, Paenibacillus, Herbaspirillum, Pseudomonas, and Agrobacterium), and other genera (Brevibacillus, Novosphingobium, Chitinophaga, Dyella, Acinetobacter, and Stenotrophomonas). The highest genetic diversity of bacteria was found in the rehabilitated area revegetated with grass indicated that it was effective in soil rehabilitation

Abstract INTRODUCTION: We aimed to evaluate the effectiveness of a symbiotic product to decolonize the intestinal tract of patients harboring multidrug-resistant (MDR) Gram-negative bacilli and to prevent nosocomial infections. METHODS: This was a randomized, double blind, placebo-controlled clinical trial, conducted in a tertiary-care university hospital. All adult hospitalized patients with a positive clinical culture and a positive rectal swab for any MDR Gram-negative bacilli were potentially eligible. Exclusion criteria were pregnancy, immunosuppression, and bowel obstruction/perforation. The intervention consisted of administering a symbiotic product (Lactobacillus bulgaricus, Lactobacillus rhamnosus, and fructo-oligosaccharides) twice a day for seven days via the oral/enteral route. RESULTS: Between August 1, 2012 and December 22, 2013, 116 of 275 eligible patients were allocated to treatment (n=57) and placebo (n=59). Overall, 101 patients received at least four doses of the study products and were included in the modified intention-to-treat analysis. The primary study outcome, a negative rectal swab for MDR Gram-negative bacilli after treatment, was identified in 16.7% (8/48) and 20.7% (11/53) of patients in the experimental and placebo group, respectively (p=0.60). The secondary outcome, the combined incidence of nosocomial respiratory and urinary tract infections, was 37.5% (18/48) in the experimental group versus 22.6% (12/53) in the control group (adjusted odds ratio: 1.95, 95% confidence interval: 0.69-5.50, p=0.21). Length of stay after the beginning of the intervention, incidence of adverse events, and in-hospital mortality rates were similar in both study groups. CONCLUSIONS: Under the present study conditions, symbiotic administration was not effective for decolonizing hospitalized patients harboring MDR Gram-negative bacilli.

OBJETIVO: descrever os achados miofuncionais orofaciais, bem como os principais problemas otorrinolaringológicos, alergológicos e ortodônticos encontrados em crianças com respiração oral. MÉTODOS: análise de prontuários de 502 crianças do Ambulatório do Respirador Oral do Hospital das Clínicas da Universidade Federal de Minas Gerais. Os participantes tinham idades entre 2 e 12 anos (mediana de 6,0 anos), sendo 289 (57,6%) do sexo masculino e 213 (42,4%) do sexo feminino. Foram coletados dados dos prontuários referentes à anamnese geral, avaliação fonoaudiológica, bem como as partes relevantes das avaliações otorrinolaringológica, alergológica e ortodôntica. Os dados foram submetidos à análise estatística. RESULTADOS: na anamnese, observou-se prevalência significante de permanência de boca aberta (98,0%), ronco (89,9%) e sialorreia noturna (68,6%). Na avaliação alergológica, verificou-se teste cutâneo positivo (59%) e rinite (57,8%) e na otorrinolaringológica, hipertrofia de adenoide (91,7%) e amígdalas (72,6%), além de mucosa nasal alterada (60,3%). A avaliação ortodôntica indicou presença de má oclusão (86,8%), perfil facial convexo (62,9%) e trespasse vertical aumentado (55,5%). Os dados da avaliação fonoaudiológica indicaram inadequação da posição habitual de lábios (70,5%), tensão de lábios (65,4%) e de língua (64,4%) alteradas, palato duro alto (57,1%), ângulo nasolabial alterado (57,0%) e assimetria facial (55,0%). CONCLUSÃO: verificaram-se alterações nas avaliações realizadas por todos os profissionais, confirmando o grande impacto da respiração oral na qualidade de vida e, portanto, a necessidade de tratamento multidisciplinar para esses pacientes.

PURPOSE: to describe orofacial myofunctional findings, as well as the main otolaryngological, allergological and orthodontic problems found in mouth breathing children. METHODS: 502 medical charts from the Mouth Breathing Outpatient Clinic from Hospital das Clínicas da Universidade Federal de Minas Gerais were analyzed. The subjects were aged between 2 and 12 years (median 6.0 years) and, about genders, 289 (57.6%) were male and 213 (42.4%) were female. The data collected was regarding general anamnesis, speech-language pathology evaluation, as well as the relevant parts of otolaryngological, allergological and orthodontic assessments. Data was submitted to statistical analysis. RESULTS: at anamnesis, significant prevalence of maintaining the mouth opened (98.0%), snoring (89.9%) and nocturnal drooling (68.6%) was observed. Allergologic evaluation showed positive skin test (59.0%) and rhinitis (57.8%) and otolaryngological assessment revealed hypertrophic adenoids (91.7%) and tonsils (72.6%) and changed nasal mucosa (60.3%). The findings on orthodontic evaluation were malocclusion (86.8%), convex facial profile (62.9%) and overbite (55.5%). Data from speech-language pathology assessment indicated inappropriate usual lips position (70.5%), facial changes in lips (65.4%) and tongue (64.4%) strength, high hard palate (57.1%), altered nasolabial angle (57.0%) and asymmetry (55.0%). CONCLUSION: alterations were found on the evaluations made by all professionals, confirming the huge impact of mouth breathing on quality of life of those children, and therefore the need for multidisciplinary treatment for these patients.