Search | SciELO

Abstract This work presents an adaptive hybrid signal precoding strategy for Cell-Free (CF) Massive multiple-input multiple-output (MIMO) systems. The proposed solution exploits the advantages of both distributed and centralized signal processing schemes to perform precoding. In our proposal, some access points (APs) are dynamically configured to be used in a centralized precoding scheme, whereas others are adjusted to employ a distributed method. Simulation results show that it is possible to achieve a good compromise between spectral efficiency (SE) and computational complexity (CC) in CF Massive MIMO systems finding a sensible balance between APs utilized in centralized and distributed precoding. To the best of our knowledge, prior-art solutions have not addressed an adaptive hybrid precoding method itself, they have only proposed a specific solution for each architecture, i.e., distributed or centralized.

https://doi.org/10.1590/2179-10742023v22i2266934

Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac)
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

SOUZA-SILVA, GUILHERME ANTONIO DE

; AQUINO, RODRIGO CESAR A. DE

; SOUSA, GEORON F. DE

; BARROS, BÁRBARA RAFAELA S.

; LIMA, MARÍLLIA RAPHAELLA C.F. DE

; CRUZ, LEONARDO C.O.

; MARCOS, BIANCA F. SÃO

; SILVA, ANNA JÉSSICA D.

; TALES, APARECIDA VIRGÍNIA S.

; DINIZ, MADI V.

; LIMA, MÔNICA MARIA C.

; SÁ, IGOR W.A. DE

; RODRIGUES, FÁBIO AUGUSTO C.

; SOUZA, EDSON B. DE

; NASCIMENTO, ARIONE V. DO

; VIEIRA, AMANDA M.

; CARVALHO, BRUNO M. DE

; CAMPELO JÚNIOR, EVÔNIO B.

; FREITAS, ANTONIO CARLOS DE

; MELO, CRISTIANE M.L. DE

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 94 N. 3 elocation e20211590

Abstract: En | Text: En | PDF: En

Abstract Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.

https://doi.org/10.1590/0001-3765202220211590

Fish-food interaction network around cage fish farming in a neotropical reservoir
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Brandão, Heleno

; Lange, Denise

; Blanco, Daniel Rodrigues

; Ramos, Igor Paiva

; Sousa, Jamile Queiroz de

; Nobile, André Batista

; Carvalho, Edmir Daniel

Acta Limnologica Brasiliensia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2021, Volume 33 elocation e18

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Objetivo Nós verificamos se peixes selvagens se alimentam de ração residual proveniente de piscicultura em tanques-rede, alterando a dieta e a rede de interação peixe-alimento. Métodos Foram avaliadas as dietas de Astyanax lacustris, Iheringichthys labrosus, Leporinus amblyrhynchus, Schizodon nasutus e Steindachnerina insculpta do Reservatório Chavantes, Bacia do Alto Paraná. Os peixes foram coletados mensalmente de março de 2008 a fevereiro de 2009 ao redor da área de piscicultura (net cage - NC) e em uma área de referência (reference site – RS), sem a influência das atividades de piscicultura. Nós verificamos os resultados usando gráficos e métricas da análise de redes complexas e análise de variância permutacional. Resultados Foram coletados 641 indivíduos das cinco espécies de peixes, 292 na área NC e 349 na RS. No total 24 itens alimentares foram consumidos pelos peixes em NC e 22 em RS. A rede de interação peixe-alimento apresentou padrão aninhado nas duas áreas avaliadas, demonstrando a estrutura generalista desta interação. Os valores de conectância e grau médio da rede de interação foram baixos. Detrito foi o item mais consumido nas duas áreas avaliadas. Três das cinco espécies avaliadas (A. lacustris, S. nasutus e I. labrosus) tiveram ração residual em suas dietas. Ração foi o quarto item mais consumido na área NC, sendo o mais frequente em indivíduos de A. lacustris e S. nasutus. Conclusões Os nossos resultados mostram que a atividade de piscicultura usando tanques-rede pode influenciar as interações tróficas dos sistemas aquáticos, bem como, demonstram a habilidade de S. nasutus, L. labrosus e A. lacustris em consumirem o novo item alimentar inserido no ambiente.

Abstract: Aim Investigating whether wild fish accept residual ration from cage fish farming to the point of changing their diet and the fish-food interaction network. Methods The diet of fish species, Astyanax lacustris, Iheringichthys labrosus, Leporinus amblyrhynchus, Schizodon nasutus and Steindachnerina insculpta, bred in Chavantes Reservoir, Upper Paraná basin, was evaluated. Samples were collected on a monthly basis - from March 2008 to February 2009 - around the cage fish farming (NC) and in a reference site (RS) free from the influence of the fish farming activity. Results were analyzed through graphs and metrics of complex network analysis, and Permutational analysis of variance. Results The total number of 641 individuals belonging to all five fish species were collected, 292 in NC and 349 in RS. The total amount of food items consumed by them comprised 24 items in NC and 22 items in RS. The fish-food interaction network has shown nested pattern in the two evaluated areas, which evidenced the generalist structure of this interaction. Connectance values and mean degree of interaction networks were low. Detritus was the most representative item consumed in both sampling sites. Three of the five evaluated species (A. lacustris, S. nasutus and I. labrosus) had residual ration in their diet. Residual ration was the fourth most consumed item in NC. It was also the most representative food item for A. lacustris and S. nasutus. Conclusions Results have shown that cage fish farming activity can influence trophic interactions in aquatic systems, as well as evidenced the ability of S. nasutus, L. labrosus and A. lacustris to take advantage of new food items in their environment.

https://doi.org/10.1590/s2179-975x10919 7 downloads

Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study,
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Prata-Barbosa, Arnaldo

; Lima-Setta, Fernanda

; Santos, Gustavo Rodrigues dos

; Lanziotti, Vanessa Soares

; Castro, Roberta Esteves Vieira de

; Souza, Daniela Carla de

; Raymundo, Carlos Eduardo

; Oliveira, Felipe Rezende Caino de

; Lima, Lucio Flavio Peixoto de

; Tonial, Cristian Tedesco

; Colleti Jr., José

; Bellinat, Ana Paula Novaes

; Lorenzo, Vivian Botelho

; Zeitel, Raquel de Seixas

; Pulcheri, Lucas

; Costa, Fernanda Ciuffo Monte da

; La Torre, Fabíola Peixoto Ferreira

; Figueiredo, Elaine Augusta das Neves

; Silva, Thiago Peres da

; Riveiro, Paula Marins

; Mota, Isabele Coelho Fonseca da

; Brandão, Igor Bromonschenkel

; Azevedo, Zina Maria Almeida de

; Gregory, Simone Camera

; Boedo, Fernanda Raquel Oliveira

; Carvalho, Rosana Novais de

; Castro, Natália Almeida de Arnaldo Silva Rodriguez

; Genu, Daniel Hilário Santos

; Foronda, Flavia Andrea Krepel

; Cunha, Antonio José Ledo A.

; Magalhães-Barbosa, Maria Clara de

Jornal de Pediatria

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2020, Volume 96 N. 5 Pages 582 - 592

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever as características clínicas de crianças e adolescentes internados em unidade de terapia intensiva com COVID-19 confirmada. Método: Estudo prospectivo, multicêntrico, observacional, em 19 unidades de terapia intensiva pediátrica. Foram incluídos pacientes entre um mês e 19 anos, admitidos consecutivamente (março a maio de 2020). As características demográficas, clínico-epidemiológicas, o tratamento e os resultados foram coletados. Os subgrupos foram comparados de acordo com as comorbidades, idade < 1 ano e necessidade de ventilação mecânica invasiva. Um modelo de regressão logística multivariável foi utilizado para preditores de gravidade. Resultados: Setenta e nove pacientes foram incluídos (10 com síndrome inflamatória multi-ssistêmica). Mediana de idade, quatro anos; 54% eram do sexo masculino (síndrome inflamatória multissistêmica, 80%); 41% tinham comorbidades (síndrome inflamatória multissistêmica, 20%). Febre (76%), tosse (51%) e taquipneia (50%) foram comuns nos dois grupos. Sintomas graves egastrointestinais e marcadores inflamatórios mais elevados foram mais frequentes na presença de síndrome inflamatória multissistêmica. Infiltrados intersticiais pulmonares foram comuns em ambos os grupos, mas o derrame pleural foi mais prevalente no grupo com síndrome inflamatória multissistêmica (43% vs. 14%). A ventilação mecânica invasiva foi utilizada em 18% (mediana 7,5 dias); antibióticos, oseltamivir e corticosteroides foram utilizados em 76%, 43% e 23%, respectivamente, mas não a hidroxicloroquina. A mediana do tempo de permanência na unidade de terapia intensiva pediátrica foi de 5 dias; duas mortes ocorreram (3%) no grupo não- síndrome inflamatória multissistêmica. Os pacientes com comorbidades eram mais velhos, e as comorbidades foram independentemente associadas à necessidade de ventilação mecânica invasiva(OR 5,5; IC95%, 1,43-21,12; P 0,01). Conclusões: Nas unidades de terapia intensiva pediátrica brasileiras, a COVID-19 apresentou baixa mortalidade, a idade inferior a um ano não foi associada a um pior prognóstico, os pacientes com síndrome inflamatória multissistêmica apresentaram sintomas mais graves, biomarcadores inflamatórios mais elevados e uma grande predominância no sexo masculino, mas apenas a presença de comorbidades e doenças crônicas foi um preditor independente de gravidade.

Abstract Objective: To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19. Method: Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity. Results: Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43-21.12; p = 0.01). Conclusions: In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.

https://doi.org/10.1016/j.jped.2020.07.002 2718 downloads

β-Carboline-1-propionic acid alkaloid: antileishmanial and cytotoxic effects
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Gabriel, Renata S.

; Amaral, Ana Claudia F.

; Lima, Iasmim C.

; Cruz, Jefferson D.

; Garcia, Andreza R.

; Souza, Hercules Antonio S.

; Adade, Camila M.

; Vermelho, Alane B.

; Alviano, Celuta S.

; Alviano, Daniela S.

; Rodrigues, Igor A.

Revista Brasileira de Farmacognosia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2019, Volume 29 N. 6 Pages 755 - 762

Abstract: En | Text: En | PDF: En

ABSTRACT Pentavalent antimonials and amphotericin B remain as the main drugs to treat human leishmaniasis. However, the high toxicity and variable efficacy of treatment have stimulated the search for novel drug candidates. Naturally occurring alkaloids have a long history of antileishmanial activity. Here, we investigate the effects of the β-carboline-1-propionic acid alkaloid isolated from Quassia amara L., Simaroubaceae, against Leishmania amazonensis and Leishmania infatum. The alkaloid was isolated after liquid-liquid fractionation followed by chromatographic purification of the Q. amara methanol extract. The antileishmanial activity was evaluated by the microdilution method, using resazurin as the viability indicator. In addition, annexin and propidium iodide were used to detect parasites undergoing apoptosis. The anti-amastigote activity of the β-carboline-1-propionic acid alkaloid was determined by the infection of RAW 264.7 macrophages. The alkaloid displayed leishmanicidal activity against Leishmania amazonensis and L. infantum promastigotes and intracellular amastigotes with 50% inhibitory concentration ranging from 2.7 ± 0.82 to 9.4 ± 0.5 µg/ml and selectivity indexes >10. Moreover, apoptotic Leishmania amazonensis (19.5%) and L. infantum (40.4%) promastigotes were detected after 5 h incubation with the alkaloid. Finally, the β-carboline-1-propionic acid alkaloid inhibited the production of NO of infected macrophages, suggesting that the intracellular amastigote elimination occurs in a nitrosative stress-independent way. The results shown here suggest that the β-carboline-1-propionic acid alkaloid has potential as an antileishmanial agent.

https://doi.org/10.1016/j.bjp.2019.08.002 402 downloads

Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Lavinas, Flavia C.

; Macedo, Ellis Helena B.C.

; Sá, Gabriel B.L.

; Amaral, Ana Claudia F.

; Silva, Jefferson R.A.

; Azevedo, Mariana M.B.

; Vieira, Bárbara A.

; Domingos, Thaisa Francielle S.

; Vermelho, Alane B.

; Carneiro, Carla S.

; Rodrigues, Igor A.

Revista Brasileira de Farmacognosia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2019, Volume 29 N. 3 Pages 389 - 399

Abstract: En | Text: En | PDF: En

ABSTRACT Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary.

https://doi.org/10.1016/j.bjp.2018.11.007 1704 downloads

OCCURRENCE OF FILARID PARASITES IN HOUSEHOLD AND SHELTERED DOGS IN THE CITY OF JOINVILLE – SANTA CATARINA, BRAZIL
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Kannenberg, Anna Karina

; Frondana, Luca

; Martins, Igor Henrique Rodrigues

; Longhi, Charlene Edianez

; Fialkowski, Michele Müller

; Milczewski, Viviane

Ciência Animal Brasileira

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2019, Volume 20 elocation e-53529

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Dentre os diversos nematódeos filarídeos que parasitam cães, alguns podem ser apatogênicos como Acanthocheilonema reconditum e outros como Dirofilaria immitis podem levar esses animais a óbito, além de terem potencial zoonótico. Nesse sentido, o objetivo deste trabalho foi realizar um levantamento da ocorrência de filarídeos em cães residentes em domicílio fixo e cães errantes que estavam temporariamente em um abrigo animal de Joinville-SC. Entre 2015 e 2017, amostras de sangue de 429 animais foram submetidas à busca de microfilárias ou antígenos de D. immitis, utilizando-se Método de Knott modificado e kit comercial de diagnóstico clínico. Vinte e quatro amostras (5,6%) apresentaram microfilárias de A. reconditum e três (0,7%) foram positivas para D. immitis, totalizando 27 (6,3%) cães positivos para a presença de filarídeos parasitos. A. reconditum teve maior ocorrência em cães provenientes de abrigos, já os três cães positivos para D. immitis eram domiciliados e não apresentavam suspeita clínica de dirofilariose. A presença desses parasitos em cães da região denota a importância do diagnóstico diferencial das espécies de microfilárias para o encaminhamento clínico adequado dos cães parasitados. As informações epidemiológicas obtidas podem orientar a comunidade médica e veterinária em relação à atenção para as suspeitas clínicas de dirofilariose canina e humana, assim como na orientação das medidas de prevenção visando a saúde pública e animal.

Abstract Parasites from the Filariidae family are among the nematodes that can infest dogs. Some may be apathogenic, such as Acanthocheilonema reconditum, and others such as Dirofilaria immitis are potentially zoonotic and may lead dogs to death. Thus, the aim of this study was to perform a survey on filarid infection in dogs with a fixed domicile and wandering dogs temporarily sheltered in the city of Joinville, SC, Brazil. Blood samples from 429 animals were collected from 2015 to 2017 and submitted to screening for microfilariae and/or D. immitis antigens. Our results revealed that twenty-four samples (5.6%) displayed A. reconditum microfilariae and three samples (0.7%) were positive for D. immitis, totaling 27 (6.3%) positive animals for filarid parasites. Additionally, A. reconditum was more prevalent in dogs from shelters, whereas the three D. immitis positive samples were from household dogs that displayed no clinical signs of the presence of parasites. The occurrence of these parasites in dogs from Joinville indicates the importance of differential diagnosis of microfilaria species for the correct clinical management of infected dogs. Our epidemiological information may help the medical and veterinary community of the region regarding clinical suspicion of canine and human heartworm disease, as well as guide preventive actions targeting public and animal health.

https://doi.org/10.1590/1809-6891v20e-53529 629 downloads

Isolation and prospection of diazotrophic rhizobacteria associated with sugarcane under organic management
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

RODRIGUES, ARIANA A.

; ARAÚJO, MARCUS VINÍCIUS F.

; SOARES, RENAN S.

; OLIVEIRA, BRUNO F.R. DE

; RIBEIRO, IGOR D.A.

; SIBOV, SERGIO T.

; VIEIRA, JOSÉ DANIEL G.

Anais da Academia Brasileira de Ciências

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2018, Volume 90 N. 4 Pages 3813 - 3829

Abstract: En | Text: En | PDF: En

Abstract Microorganisms associated with organic management are essential in nutrient transformation and release for plant use. The present study aimed to isolate, identify and characterize plant growth promoting diazotrophic rhizobacteria associated with sugarcane under organic management. Rhizospheres of organic sugarcane varieties IAC 911099 and CTC4 were sampled and inoculated onto nitrogen free NFb and Burk media. The isolated microorganisms were screened in vitro concerning their ability to produce plant growth promoting factors. Eighty-one bacteria were isolated; 45.6% were positive for the nifH gene and produced at least one of the evaluated plant growth promotion factors. The production of indole-3-acetic acid was observed in 46% of the isolates, while phosphate solubilization was observed in 86.5%. No isolates were hydrogen cyanide producers, while 81% were ammonia producers, 19% produced cellulases and 2.7%, chitinases. Microorganisms belonging to the Burkholderia genus were able to inhibit Fusarium moniliforme growth in vitro. Plant growth promoting microorganisms associated with organic sugarcane, especially belonging to Burkholderia, Sphingobium, Rhizobium and Enterobacter genera, can be environmentally friendly alternatives to improve sugarcane production.

https://doi.org/10.1590/0001-3765201820180319 1373 downloads

Comparative mitogenomic analyses of Amazona parrots and Psittaciformes
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Lima, Nicholas Costa Barroso

; Soares, André Elias Rodrigues

; Almeida, Luiz Gonzaga de Paula

; Costa, Igor Rodrigues da

; Sato, Fernanda Midori

; Schneider, Patricia

; Aleixo, Alexandre

; Schneider, Maria Paula

; Santos, Fabrício R.

; Mello, Claudio V.

; Miyaki, Cristina

; Vasconcelos, Ana Tereza R.

; Prosdocimi, Francisco

Genetics and Molecular Biology

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2018, Volume 41 N. 3 Pages 593 - 604

Abstract: En | Text: En | PDF: En

Abstract Amazon parrots are long-lived birds with highly developed cognitive skills, including vocal learning. Several parrot mitogenomes have been sequenced, but important aspects of their organization and evolution are not fully understood or have limited experimental support. The main aim of the present study was to describe the mitogenome of the blue-fronted Amazon, Amazona aestiva, and compare it to other mitogenomes from the genus Amazona and the order Psittaciformes. We observed that mitogenomes are highly conserved among Amazon parrots, and a detailed analysis of their duplicated control regions revealed conserved blocks. Population level analyses indicated that the specimen analyzed here seems to be close to A. aestiva individuals from Bahia state. Evolutionary relationships of 41 Psittaciformes species and three outgroups were inferred by BEAST. All relationships were retrieved with high support.

https://doi.org/10.1590/1678-4685-gmb-2017-0023 1973 downloads

10.

Potent antileukemic action of naphthoquinoidal compounds: evidence for an intrinsic death mechanism based on oxidative stress and inhibition of DNA repair
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Cavalcanti, Bruno C.

; Cabral, Igor O.

; Rodrigues, Felipe A. R.

; Barros, Francisco W. A.

; Rocha, Danilo D.

; Magalhães, Hemerson I. F.

; Moura, Dinara J.

; Saffi, Jenifer

; Henriques, João A. P.

; Carvalho, Tatiane S. C.

; Moraes, Manoel O.

; Pessoa, Cláudia

; Melo, Isadora M. M. de

; Silva Júnior, Eufrânio N. da

Journal of the Brazilian Chemical Society

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jan 2013, Volume 24 N. 1 Pages 145 - 163

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo descreve a acentuada atividade citotóxica da nor-β-lapachona, seus derivados arilamino substituídos, naftoquinonas iodadas e metilada, além de nor-β-lapachonas 1,2,3-triazólicas, contra quatro linhagens de células de leucemia humana (HL-60, K562, Molt-4 e Jurkat). Nor-β-lapachonas arilamino substituídas foram identificadas com potente atividade, revelando-se como potenciais protótipos contra as linhagens tumorais descritas. Estudos utilizando o ensaio cometa evidenciaram danos ao ácido desoxirribonucleico (ADN) causado pelos derivados arilamino substituídos devido o aumento dos níveis intracelulares de espécies reativas de oxigênio (ERO's). Células de HL-60 foram selecionadas para a continuidade dos estudos de mecanismos moleculares subjacentes e apoptose induzida pelos derivados quinoidais foi observada por análise de citometria de fluxo. Cepas de Saccharomyces cerevisiae foram utilizadas para uma investigação preliminar sobre o mecanismo de ação em topoisomerases de ADN. Os estudos sugerem que, aparentemente, a citotoxidade dos compostos não envolve a inibição de topoisomerases, mas que o tratamento prejudica a atividade de reparação do ADN, provocando assim a morte celular. A capacidade em induzir apoptose e aberrações cromossômicas em fibroblastos de pulmão de hamster chinês (células V79) também foi investigada. Núcleos apoptóticos foram observados e nossos estudos indicam uma correlação entre dano ao ADN e apoptose.

The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β-lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor cell lines. Moreover, cells treated with these compounds showed DNA damage according to the standard comet assay, a finding that was, at least in part, due to increased intracellular levels of ROS. HL-60 cells were chosen to study the underlying molecular mechanisms of cytotoxicity. Drug-induced apoptosis in HL-60 cells was observed by flow cytometry analyses. Strains of Saccharomyces cerevisiae were used for a preliminary investigation into the mechanism of drug action on DNA topoisomerases. These results suggested that the cytotoxicity of these compounds apparently does not involve topoisomerase inhibition, but that treatment impairs DNA repair activity, thus triggering cell death. Considering their pro-oxidant properties, we investigated the ability of these compounds to induce apoptosis and chromosomal aberrations as micronuclei in Chinese hamster lung fibroblasts (V79 cells). Morphological apoptotic nuclei and micronuclei induction following drug treatment were observed, suggesting a correlation between DNA damage and apoptosis.

3711 downloads

11.

Cover layers to the growth of trees and shrobs over a sulfide spoil from gold mining
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Assis, Igor Rodrigues de

; Dias, Luiz Eduardo

; Abrahão, Walter Antônio Pereira

; Ribeiro Jr, Emerson Silva

; Mello, Jaime Wilson Vargas de

Revista Árvore

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2011, Volume 35 N. 4 Pages 941 - 947

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este trabalho foi desenvolvido em área de mineração de ouro no Município de Paracatu, MG, Brasil, durante o período de março de 2000 a novembro de 2005. O substrato estudado foi um filito que contém sulfetos como pirita e arsenopirita. O objetivo deste trabalho foi avaliar a sobrevivência e crescimento de espécies vegetais sobre diferentes combinações de camadas de cobertura e de selamento sobre um substrato sulfetado. O tratamento 1 possuía saprolito (B1) na camada selante (SL) e B1 com calagem (B1L) na camada de cobertura (CL). O tratamento 2 possuía B1 na SL e B1L + solo com calagem (SoL) como CL. O tratamento 3 possuía B1 + SoL como SL e B1L como CL. O tratamento 4 possuía B1 + SoL como SL e B1L + SoL como CL. As espécies utilizadas foram Acacia farnesiana, A. holosericea, A. polyphylla, Albizia lebbeck, Clitoria fairchildiana, Flemingia sp., Mimosa artemisiana, M. bimucronata e Enterolobium contortisiliquum. Aos 40 e 57 meses após o plantio foram avaliados diâmetro do colo, altura e contagem das plantas vivas. A maior taxa de sobrevivência (80%) foi observada no tratamento com presença de horizonte B latossólico nas camadas selante e cobertura. De modo geral, M. bimucronata e A. farnesiana mostraram as mais altas taxas de sobrevivência. A teor de arsênio extraído por Mehlich 3 na camada de cobertura variou de 0,00 a 14,69 mg dm-3 entre os tratamentos. Os resultados indicaram que a utilização de diferentes camadas sobre o substrato sulfetado permite a rápida revegetação da área remanescente de mineração.

This work was done at a gold mine company in Paracatu, MG, Brazil, and was conducted from March 2000 to November 2005. The substrate (spoil) studied was a phillite rock which contains sulfides such as pyrite and arsenopyrite. This study aimed to evaluate the survival and growth of plant species on different combinations of substrate layers over the spoil. These layers were a cover layer and a sealing layer, both deposited over the spoil. The treatment 1 had saprolite (B1) in the sealing layer (SL) and B1 with liming (B1L) in the cover layer (CL). The treatment 2 had B1 in SL and B1L + soil with liming (SoL) in the CL. The treatment 3 had B1 + SoL in the SL and B1L in the CL. The treatment 4 had B1 + SoL in the SL and B1L + SoL in the CL. The plant species used were Acacia farnesiana, A. holosericea, A. polyphylla, Albizia lebbeck, Clitoria fairchildiana, Flemingia sp., Mimosa artemisiana, M. bimucronata e Enterolobium contortisiliquum. Forty and 57 months after planting, collardiameter, height, and living plants were evaluated. The greatest survival rate was oobservedintreatmentwith B horizon of an Oxisoil in both layers, with 80 %. In general, M. bimucronata and A. farnesiana species showed the highest survival rate. The arsenic-content by Mehlich 3 in the cover layer ranged from 0.00 to 14.69 mg dm- 3 among treatments. The experimental results suggest that layers combinations above the sulfide substrate allow the rapid revegetation of the spoil.

1979 downloads

12.

INFLUÊNCIA DA INOCULAÇÃO DE Fusarium spp. E NÍVEIS DE SOMBREAMENTO NO CRESCIMENTO E DESENVOLVIMENTO DA ERVA-MATE
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Poletto, Igor

; Muniz, Marlove Fátima Brião

; Ceconi, Denise Ester

; Mezzomo, Ricardo

; Rodrigues, Johnathan

Ciência Florestal

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2010, Volume 20 N. 3 Pages 513 - 521

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A erva-mate (Ilex paraguariensis A. St.-Hil.) é uma espécie amplamente cultivada no sul do Brasil e países vizinhos. Suas folhas e galhos finos, preparados segundo método apropriado, fornecem o mate ou chimarrão, o mais popular chá consumido no Brasil e exportado para todo o mundo. Com o aumento da área plantada, sobretudo na última década, os problemas fitossanitários causados por pragas e doenças aumentaram e, dentre estes, a podridão-de-raízes vem se tornando um dos principais. A doença é causada por Fusarium spp. e provoca sérios danos decorrentes da destruição do sistema radicular, ocasionando, nos casos mais graves, morte da planta. A erva-mate é uma espécie que habita o sub-bosque da mata e o cultivo de forma homogênea a pleno sol pode ser um fator estressante ocasionando menor crescimento e desenvolvimento e também torná-la mais susceptível à podridão-de-raízes. Assim, foram instalados experimentos na área do Viveiro Florestal pertencente ao Departamento de Ciências Florestais da Universidade Federal de Santa Maria com o objetivo de confirmar tais hipóteses. O experimento foi desenvolvido em um esquema fatorial (2 x 5), composto pela inoculação de Fusarium spp. e por níveis de sombreamento. Foi observado que plantas submetidas aos menores níveis de sombreamento ou a pleno sol tiveram seu desenvolvimento prejudicado e ficaram mais suscetíveis à doença. As plantas inoculadas com Fusarium spp. tiveram menor desenvolvimento em comparação com as não inoculadas, especialmente nos menores níveis de sombreamento.

ABSTRACT The erva-mate (Ilex paraguariensis A. St.-Hil.) is a species broadly cultivated in southern Brazil and neighboring countries, whose leaves and fine branches, prepared according to the appropriate method, make the mate or “chimarrão”, the most popular tea consumed in Brazil and exported around the world. With an increasing planted area, mainly in the last decade, phytosanitary problems caused by pests and disease have increased in this crop and root-rot is becoming one of the main problems. The disease is caused by Fusarium spp. and it causes serious damage to the roots, in the most serious cases, leading to the death of the plant. The erva-mate is a species that inhabits the forest underwood, and cultivation in a homogeneous way to full sun can be a stressful factor for the species causing less growth and development and, also, more susceptibility to root-rot. Therefore, experiments were conducted in the Forest Nursery area belonging to Forest Sciences Department of the Federal University Santa Maria with the objective of confirming these assumptions. The experiment was conducted in a factorial design (2 x 5), composed by Fusarium spp. inoculation and by shading levels. It was verified that plants submitted to lower shading levels or full sun had less development and were more susceptible to the disease. The plants inoculated with Fusarium spp. had less development in comparison with non-inoculated plants, mainly at the lower shading levels.

https://doi.org/10.5902/198050982065 373 downloads

13.

INOCULAÇÃO DE Fusarium oxysporum E Fusarium solani E NÍVEIS DE SOMBREAMENTO NA ERVA-MATE: INFLUÊNCIA NA SEVERIDADE DA PODRIDÃO-DE-RAÍZES
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Poletto, Igor

; Muniz3, Marlove Fátima Brião

; Ceconi, Denise Ester

; Araujo, Maristela Machado

; Rodrigues, Johnathan

; Mezzomo, Ricardo

Ciência Florestal

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2009, Volume 19 N. 3 Pages 267 - 278

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A erva-mate (Ilex paraguariensis A. St.-Hil.) é uma espécie amplamente cultivada na Região Sul do Brasil. Com o aumento da área plantada, sobretudo na última década, os problemas fitossanitários causados por pragas e doenças aumentaram e, dentre estes, a podridão-de-raízes vem se tornando um dos principais. Dentre os patógenos causadores dessa doença, Fusarium oxysporum Schlecht. e Fusarium solani (Mart.) Sacc são os principais. Esses fungos provocam sérios danos decorrentes da destruição do sistema radicular, ocasionando, nos casos mais graves, a morte da planta. Suspeita-se que a incidência e a severidade da doença são influenciadas pelo cultivo de ervais em diferentes níveis de sombreamento ou a pleno sol. Assim, foram instalados experimentos na área do Viveiro Florestal pertencente ao Departamento de Ciências Florestais/CCR/UFSM com o objetivo de confirmar tal hipótese. O experimento foi conduzido em um esquema fatorial (2 x 5), composto pela inoculação de Fusarium oxysporum e Fusarium solani e por níveis de sombreamento. Verificou-se que as plantas submetidas aos menores níveis de sombreamento ou a pleno sol ficaram predispostas à doença.

ABSTRACT Ilex paraguariensis A. St.-Hil. is a broadly cultivated species in the South of Brazil. With the increasing planted area, mainly in the last decade, fitosanitary problems caused by pest and diseases have increased in this crop, and the root-rot is becoming one of the main problems. Among the pathogens, Fusarium oxysporum Schlecht. and Fusarium solani (Mart.) Sacc are the main ones. These fungi provoke severe damages resulting in the destruction of the root system and, in the most serious cases, they cause the death of the plant. It is suspected that the incidence and severity of disease are influenced by cultivation of Ilex paraguariensis in different levels of shading or full sun. Therefore, experiments were conducted in the Forest Nursery area belonging to Forest Sciences Department/CCR/UFSM with the objective of confirming this assumption. The experiment was conducted in a factorial design (2 x 5), composed by Fusarium oxysporum and Fusarium solani inoculation and by shading levels. It was verified that the plants submitted to lower shading levels or full sun had their predisposed to the disease.

https://doi.org/10.5902/19805098881 589 downloads

Showing

itens per page

Page of 1 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »