Resumen Introducción: el objetivo de este estudio fue analizar la relación entre los valores de IL13 y su pronóstico en pacientes con artritis reumatoidea (AR) y enfermedad pulmonar intersticial (EPI). Materiales y métodos: estudio de cohorte prospectiva. Se midió IL13 en suero y se dividió la cohorte en dos grupos con la mediana de IL13 como punto de corte. Se estudió el tiempo hasta una caída de la capacidad vital forzada (CVF) mayor o igual al 5% con el método de Kaplan Meier (KM) y regresión de Cox. Resultados: se incluyeron 47 pacientes. La media (DE) de tiempo de seguimiento fue de 12,7 (12,5) meses. El estimador de KM a 15 meses fue de 0,48 (IC 95% 0,13-0,76) en el grupo con valores elevados de IL13 y de 0,86 (IC 95% 0,54-0,93) en el otro grupo (p=0,037). En el análisis de Cox multivariado los valores elevados de IL13 se asociaron con una caída de la CVF mayor o igual al 5% en el seguimiento (HR 17.64 (IC 95% 1,89-164,1) p=0,012). Conclusiones: los valores elevados de IL13 se asociaron con peor evolución funcional en esta cohorte prospectiva de pacientes con AR y EPI.

Abstract Introduction: the aim of our study was to analyze the relationship between the concentrations of IL13 in serum and the prognosis of interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients. Materials and methods: we conducted a prospective cohort study. We measured IL13 levels in serum. Patients were divided in two groups using the median of IL13 value as cut off point. Time to a decline of 5% or more in FVC% from basal measurement was estimated using Kaplan Meier method. Univariate and multivariate Cox models were applied. Results: we included 47 patients. The mean (SD) time of follow-up was 12.7 (12.5) months. The Kaplan Meier estimator at 15 months was 0.48 (CI 95% 0.13-0.76) in the group with higher values of IL13, and 0.86 (CI95% 0.54-0.93) in the other group (p=0.037). In the Cox multivariate analysis, the values of IL13 were significantly associated with a decline of 5% or more in FVC% in the follow-up (HR 17.64 (CI 95% 1.89-164.1) p=0.012). Conclusions: our results indicate that patients with higher values of IL13 in serum presented higher decline in FVC% during their follow-up.

Neste artigo propõe-se analisar a relação entre consciência histórica e consciência organizativa no Movimento dos Trabalhadores Rurais Sem Terra (MST), considerando-se o lugar ocupado pelo estudo da história na formação de quadros políticos num período de consolidação do movimento social. Ao longo dos anos, meios de comunicação e materiais didáticos do MST se tornaram instrumentos de difusão de representações políticas, o que permite entender como o movimento social deu sentido ao passado e ao ensino de História na organização dos sem-terra. Trata-se de uma abordagem sobre representações que delinearam funções preliminares da consciência histórica e do ensino de História na mobilização dos trabalhadores rurais sem-terra.

This article aims to analyze the relationship between historical consciousness and organizational consciousness of the Landless Rural Workers Movement (MST), considering the role played by the study of history to form political cadres in a period that the social movement was being consolidated. Over the years, MST media and course books became tools to spread political representations, which allow us to understand how the social movement provided meaning to the past as well as to history teaching within the organization. This is an approach about representations that designed the primary functions of historical consciousness and history teaching in the rural landless workers mobilization.