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Resumen: Introducción: El síndrome antifosfolipídico (SAF) es una afección de origen autoinmune caracterizada por trombosis, pérdidas fetales recurrentes y anticuerpos antifosfolipídicos (aFL). Existen manifestaciones clínicas no contempladas en los criterios clasificatorios, que se denominan manifestaciones no criterio. Objetivo: Analizar las manifestaciones clínicas del SAF, enfatizando las manifestaciones no criterio y su relación con el perfil de autoanticuerpos en un hospital general de Montevideo, Uruguay. Métodos: Se realizó un estudio retrospectivo de las historias clínicas de pacientes con diagnóstico definitivo o sospecha de SAF en un servicio de medicina ambulatoria de enfermedades autoinmunes, en el Hospital Maciel, asistidos entre el 2010 y 2019. Resultados: Se incluyeron 78 pacientes, con edad media de 50,3 ± 14,5 años, 69 (88,5%) correspondió a sexo femenino. Cuarenta y seis (59,0%) pacientes presentaron SAF secundario, de los cuales 28 (35,9%) asociaron LES. La trombosis venosa de miembros inferiores fue la manifestación más frecuente (51,3%). Dieciocho (24,0%) pacientes presentaron trombosis arteriales en forma de accidente cerebrovascular. Cincuenta y nueve (75.6%) casos presentaron, además de las manifestaciones clasificatorias, alguna de las manifestaciones “no criterio” y éstas se manifestaron de forma aislada en 10 (12.8%) pacientes. Las manifestaciones no clasificatorias más frecuentes fueron artralgias, livedo reticularis, migraña y trombocitopenia. Se observó una asociación significativa entre la presencia de anti-β2GPI con manifestaciones cutáneas y de trombocitopenia con al menos una manifestación trombótica. Conclusiones: Las manifestaciones “no criterio” del SAF se presentaron en casi 3 de cada 4 casos, frecuencia similar a la observada en otras series. La presencia aislada de manifestaciones “no criterio” podrían hacer sospechar un SAF y en algunos casos, conducir a la solicitud de anticuerpos.

Abstract: Introduction: Antiphospholipid syndrome (APS) is an autoimmune condition characterized by thrombosis, recurrent fetal loss, and antiphospholipid antibodies. There are clinical manifestations not contemplated in the classification criteria, which are called non-criterion manifestations. Objective: To analyze the clinical manifestations of APS, emphasizing the non-criterion manifestations and their relationship with the autoantibody profile in a general hospital in Montevideo, Uruguay. Methods: A retrospective analysis of the medical records of patients with a definitive or suspected diagnosis of APS in an outpatient medicine service for autoimmune diseases, at the Maciel Hospital, assisted between 2010 and 2019, was carried out. Results: 78 patients were included, with a mean age of 50.3 +/- 14.5 years, 69 (88.5%) were female. Forty-six (59.0%) patients presented secondary APS, of which 28 (35.9%) associated SLE. Venous thrombosis of the lower limbs was the most frequent manifestation (51.3%). Eighteen (24.0%) patients presented arterial thrombosis in the form of cerebrovascular accident. Fifty-nine (75.6%) cases presented, in addition to the classification manifestations, some of the "non-criterion" manifestations and these manifested in an isolated way in 10 (12.8%) patients. The most frequent non-classifying manifestations were arthralgia, livedo reticularis, migraine and thrombocytopenia. A significant association was observed between the presence of anti-β2GPI with cutaneous manifestations and thrombocytopenia with at least one thrombotic manifestation. Conclusions: Non-criterion manifestations of APS occurred in almost 3 out of 4 cases, a frequency similar to that observed in other series. The isolated presence of “non-criterion” manifestations could lead to suspicion of APS and, in some cases, lead to the request for antibodies.

Resumo: Introdução: A síndrome antifosfolipídica (SAF) é uma doença de origem auto-imune caracterizada por trombose, perdas fetais recorrentes e anticorpos antifosfolípidos (aFL). Existem manifestações clínicas não abrangidas pelos critérios de classificação, que são designadas por manifestações não-critério. Objetivo: Analisar as manifestações clínicas da SAF, enfatizando as manifestações não-critério e sua relação com o perfil de auto-anticorpos em um hospital geral de Montevidéu, Uruguai. Métodos: Foi realizado um estudo retrospectivo dos prontuários de pacientes com diagnóstico definitivo ou suspeita de SAF em um serviço ambulatorial de doenças autoimunes do Hospital Maciel, atendidos entre 2010 e 2019. Resultados: Foram incluídos 78 pacientes, com idade média de 50,3 +/- 14,5 anos, sendo 69 (88,5%) do sexo feminino. Quarenta e seis (59,0%) pacientes apresentavam PFS secundária, dos quais 28 (35,9%) tinham LES associado. A trombose venosa dos membros inferiores foi a manifestação mais frequente (51,3%). Dezoito (24,0%) doentes apresentaram trombose arterial sob a forma de acidente vascular cerebral. Cinquenta e nove (75,6%) casos apresentaram, para além das manifestações classificatórias, algumas das manifestações "não-critério" e estas manifestações foram isoladas em 10 (12,8%) doentes. As manifestações não classificatórias mais frequentes foram artralgias, livedo reticularis, enxaqueca e trombocitopenia. Foi observada uma associação significativa entre a presença de anti-β2GPI com manifestações cutâneas e trombocitopenia com pelo menos uma manifestação trombótica. Conclusões: As manifestações "não-critério" de SAF ocorreram em quase 3 de cada 4 casos, frequência semelhante à observada noutras séries. A presença isolada de manifestações "não-critério" pode levantar a suspeita de SAF e, nalguns casos, levar à pesquisa de anticorpos.

https://doi.org/10.26445/08.02.3

Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis
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SALES-PERES, Silvia Helena de Carvalho

; AZEVEDO-SILVA, Lucas José de

; CASTILHO, Ana Virginia Santana Sampaio

; CASTRO, Marcelo Salmazo

; SALES-PERES, André de Carvalho

; MACHADO, Maria Aparecida de Andrade Moreira

Brazilian Oral Research

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2023, Volume 37 elocation e031

Abstract: En | Text: En | PDF: En

Abstract This meta-analysis aimed to investigate the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. PubMed, EMBASE, SciELO, Web of Science, and SCOPUS databases were systematically searched. Studies have been conducted analyzing propolis’s effects on COVID-19 and periodontitis. The study was conducted according to the PRISMA statement and registered in PROSPERO. Risk of Bias (RoB) assessment and meta-analysis of clinical studies were performed (Review Manager 5, Cochrane). The certainty of the evidence was assessed using GradePro (GDT). Studies have shown propolis flavonoids inhibit viral replication in several DNA and RNA viruses, including coronaviruses. Propolis components have an aminopeptidase inhibitor activity that can inhibit the main proteases of SARS viruses and seem to inhibit protein spikes, which are sites of most mutations in SARS-CoV strains. The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001). The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses. Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity. Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0031

Saúde Mental na Universidade: Atendimento Psicológico Online na Pandemia da Covid-19
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Correia, Karla Carneiro Romero

; Araújo, Juliana Lima de

; Barreto, Sarah Rebeca Viana

; Bloc, Lucas

; Melo, Anna Karynne

; Moreira, Virginia

Psicologia: Ciência e Profissão

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2023, Volume 43 elocation e245664

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract With the COVID-19 pandemic, the university context, which had already been the stage for discussions regarding mental health, has experienced more severe crises by students. In view of this scenario, the Solidarity Listening project was developed, aimed at the mental health of undergraduate and graduate students. In this article, we aim to discuss online psychological care with psychology students during the period of strict social isolation (May to June 2020). We carried out, with volunteer psychologists, a focus group aimed at the experience of short-termonline psychological care in the pandemic context. This is a qualitative study, carried out with 11 clinical psychologists participating in the aforementioned project. From a critical phenomenological analysis, the results were divided into five categories: a) limitations and contributions of the project; b) the importance of training and clinical supervision for the quality of the project; c) online psychological care; d) being a clinical psychologist during the COVID-19 crisis; and e) emerging demands in psychological care in quarantine. Finally, we discuss the importance of demystifying psychological care in crisis situations, especially in the online modality, promoting questions regarding the training and performance of professionals, to be aware of the psychological demands that the context of crisis entails in society.

Resumen La pandemia del covid-19 provocó que las universidades, que ya habían sido escenario de discusiones sobre la salud mental, experimentaran crisis más severas entre los estudiantes. Ante este escenario, se desarrolló el proyecto Escucha Solidaria, dirigido a la salud mental de estudiantes de grado y posgrado. Este artículo pretende discutir la atención psicológica en línea con estudiantes de Psicología durante el período de aislamiento social más estricto (mayo/junio de 2020). Se conformó un grupo focal con los psicólogos voluntarios orientado a la práctica de la atención psicológica en línea, a corto plazo, en el contexto de una pandemia. Se trata de un estudio cualitativo, realizado con 11 psicólogos clínicos que participaron en el mencionado proyecto. A partir del análisis fenomenológico crítico, los resultados se dividieron en cinco categorías: a) limitaciones y aportes del proyecto; b) importancia de la capacitación y la supervisión clínica para la calidad del proyecto; c) atención psicológica en línea; d) ser psicólogo clínico durante la crisis del covid-19; y e) demandas emergentes en atención psicológica en la cuarentena. Se concluye que es importante desmitificar la atención psicológica en situaciones de crisis, especialmente en la modalidad en línea, al promover principalmente preguntas sobre la formación y el desempeño de los profesionales con el fin de ser conscientes de las demandas psicológicas que el contexto de crisis conlleva la sociedad.

Resumo Com a pandemia da covid-19, o contexto universitário, que já vinha sendo palco de discussões em relação à saúde mental, tem vivenciado crises mais severas pelos estudantes. Diante deste cenário, foi desenvolvido o projeto Escuta Solidária, voltado à saúde mental dos discentes de graduação e de pós-graduação. Neste artigo, temos como objetivo discutir o atendimento psicológico online com estudantes do curso de psicologia durante o período de isolamento social rígido (maio a junho de 2020). Fizemos, com os psicólogos voluntários, um grupo focal direcionado para a experiência de atendimento psicológico online de curta duração no contexto pandêmico. Trata-se de um estudo qualitativo, realizado com os 11 psicólogos clínicos participantes do referido projeto. A partir de uma análise fenomenológica crítica, os resultados foram divididos em cinco categorias: a) limitações e contribuições do projeto; b) a importância da capacitação e supervisão clínica para a qualidade do projeto; c) atendimento psicológico online; d) ser psicólogo clínico durante a crise da covid-19; e e) demandas emergentes nos atendimentos psicológicos na quarentena. Por fim, discutimos a importância da desmistificação do atendimento psicológico em situações de crise, especialmente na modalidade online, fomentando questionamentos à formação e atuação dos profissionais, no sentido de estarmos atentos às demandas psicológicas que o contexto de crise acarreta na sociedade.

https://doi.org/10.1590/1982-3703003245664

Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates
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Fontes, Gleide Gatti

; Freitas, Rodrigo de Barros

; Almeida, Palloma Porto

; Lima, Luciana Moreira

; Cardoso, Silvia Almeida

; Pizziolo, Virginia Ramos

; Tabach, Ricardo

; Wanderley, Almir Gonçalves

; Arida, Ricardo Mario

; Caricati-Neto, Afonso

; Taha, Murched Omar

; Carvalho, Camilo Amaro de

; Tallo, Fernando Sabia

; Menezes-Rodrigues, Francisco Sandro

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e383723

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusions: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile.

https://doi.org/10.1590/acb383723

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists.

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells
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Moreira, Leyllane Rafael

; Silva, Ana Carla

; Costa Oliveira, Cíntia Nascimento da

; Silva Júnior, Claudeir Dias da

; Nascimento, Amanda Vasconcelos

; Oliveira, Kamila Kássia dos Santos

; Soares, Ana Karine de Araújo

; Saraiva, Karina Lidianne Alcântara

; Paiva Cavalcanti, Milena de

; Lorena, Virginia Maria Barros de

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220295

Abstract: En | Text: En | PDF: En

BACKGROUND Trypanosoma cruzi, which causes Chagas disease (CD), is a versatile haemoparasite that uses several strategies to evade the host’s immune response, including adipose tissue (AT), used as a reservoir of infection. As it is an effective barrier to parasite evasion, the effectiveness of the drug recommended for treating CD, Benznidazole (BZ), may be questionable. OBJECTIVE To this end, we evaluated the parasite load and immunomodulation caused by BZ treatment in the culture of adipocytes differentiated from human adipose tissue-derived stem cells (ADSC) infected with T. cruzi. METHODS The ADSC were subjected to adipogenic differentiation. We then carried out four cultures in which we infected the differentiated AT with trypomastigote forms of the Y strain of T. cruzi and treated them with BZ. After the incubation, the infected AT was subjected to quantitative polymerase chain reaction (qPCR) to quantify the parasite load and transmission electron microscopy (TEM) to verify the infection. The supernatant was collected to measure cytokines, chemokines, and adipokines. FINDINGS We found elevated secretion of IL-6, CXCL-10/IP-10, CCL2/MCP-1, CCL5/RANTES, and leptin in infected fat cells. However, treatment with BZ promoted a decrease in IL-6. MAIN CONCLUSION Therefore, we believe that BZ has a beneficial role as it reduces inflammation in infected fat cells.

https://doi.org/10.1590/0074-02760220295

Factors associated with sexual practices and positions performed by pregnant women: a cross-sectional study
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Pereira, Emanuelly Vieira

; Belém, Jameson Moreira

; Alves, Maria Juscinaide Henrique

; Torquato, Jaqueline Alves Silva

; Firmino, Paulo Renato Alves

; Fialho, Ana Virgínia de Melo

; Quirino, Glauberto da Silva

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 3 elocation e20210162

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: identificar fatores associados às práticas e posições sexuais realizadas por mulheres grávidas. Métodos: estudo transversal, quantitativo, realizado com 354 mulheres grávidas, no interior do Ceará, Brasil, em 2016. Para coleta de dados, utilizou-se formulário e Questionário de Sexualidade na Gestação. Resultados: houve redução na iniciativa sexual da mulher, disposição sexual do casal, práticas sexuais e da maioria das posições sexuais, ao passo que se constatou manutenção das atividades sexuais preliminares e da iniciativa para realizá-las. Reduziram-se práticas e posições sexuais (p<0,0001): atividades sexuais preliminares, disposição sexual, lubrificação, orgasmo, dor ou desconforto, posições sexuais, práticas sexuais e satisfação sexual. Práticas e posições sexuais aumentaram (p<0,0001) em função de: escolaridade, número de partos, vida sexual, desejo e excitação e disposição sexual da gestante, frequência do orgasmo e de práticas sexuais. Conclusões: práticas e posições sexuais de mulheres grávidas foram afetadas por domínios da função sexual, aspectos sexuais, reprodutivos, físicos e psicológicos.

ABSTRACT Objectives: to identify factors associated with the sexual practices and positions performed by pregnant women. Methods: a cross-sectional, quantitative study conducted with 354 pregnant women, in the interior of Ceará, Brazil, in 2016. For data collection, a form and a Pregnancy Sexuality Questionnaire were used. Results: there was a reduction in the sexual initiative of the woman, sexual disposition of the couple, sexual practices and most of the sexual positions, while the maintenance of preliminary sexual activities and initiative to perform them was verified. Sexual practices and positions decreased (p<0.0001): preliminary sexual activities, sexual disposition, lubrication, orgasm, pain or discomfort, sexual positions, sexual practices, and sexual satisfaction. Sexual practices and positions increased (p<0.0001) as a function of: education, number of deliveries, sexual life, desire and arousal, and sexual disposition of the pregnant woman, frequency of orgasm and of sexual practices (p<0.0001). Conclusions: sexual practices and positions of pregnant women were affected by domains of sexual function, sexual, reproductive, physical, and psychological aspects.

RESUMEN Objetivos: identificar factores relacionados a prácticas y posiciones sexuales realizadas por mujeres embarazadas. Métodos: estudio transversal, cuantitativo, realizado con 354 mujeres embarazadas, en interior Cearense, Brasil, en 2016. Utilizado formulario y Encuesta de Sexualidad en el Embarazo, para recolecta de datos. Resultados: hubo reducción en la iniciativa sexual de la mujer, disposición sexual del casal, prácticas sexuales y mayoría de las posiciones sexuales, mientras que se constató manutención de actividades sexuales preliminares e iniciativa para realizarlas. Redujeron prácticas y posiciones sexuales (p<0,0001): actividades sexuales preliminares, disposición sexual, lubricación, orgasmo, dolor o incomodidad, posiciones sexuales, prácticas sexuales y satisfacción sexual. Prácticas y posiciones sexuales aumentaron (p<0,0001) en función de: escolaridad, número de partos, vida sexual, deseo y excitación y disposición sexual de la embarazada, frecuencia del orgasmo y prácticas sexuales. Conclusiones: prácticas y posiciones sexuales de embarazadas fueron afectadas por dominios de la función sexual, aspectos sexuales, reproductivos, físicos y psicológicos.

https://doi.org/10.1590/0034-7167-2021-0162 104 downloads

Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease
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Frade, Virgínia Paula

; Moreira, Carlos Henrique Valente

; Sabino, Ester Cerdeira

; Bedor, Danilo César Galindo

; Ghilard, Fábio de Rose

; Oliveira, Cláudia Di Lorenzo

; Sanches, Cristina

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e4

Abstract: En | Text: En | PDF: En

ABSTRACT The present study aimed to establish a population pharmacokinetic (PopPK) modeling of benznidazole (BZD) in Brazilian patients with chronic Chagas disease. This was part of a Brazilian prospective cohort study with eight patients diagnosed with Chagas disease during the beginning of BZD treatment up to the 60th day. On the 15th day of treatment, a blood sampling was collected and analyzed. A one-compartment PK model was developed using Pmetrics. Patients with an average age of 50.3 (SD: 6.2) years old, 6 female patients and 2 males, 70.2 kg (14.2), receiving a 5 mg/Kg/day dose were included. PK parameters estimated for CL, V and Ka were 6.27 L/h, 38.97 L and 1.66 h-1, respectively. This is the first study to establish a population pharmacokinetic modeling of BZD in Brazilian patients with chronic Chagas disease. Therefore, further studies are needed to obtain the complete characterization of BZD pharmacokinetics.

https://doi.org/10.1590/s1678-9946202264004

10.

Cognitive-behavioral program to control lower urinary tract symptoms after radical prostatectomy: a randomized clinical trial
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Izidoro, Lívia Cristina de Resende

; Mata, Luciana Regina Ferreira da

; Azevedo, Cissa

; Paula, Adriano Augusto Peclat de

; Pereira, M. Graça

; Santos, Jackelline Evellin Moreira dos

; Brasil, Virginia Visconde

; Oliveira, Lizete Malagoni de Almeida Cavalcante

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 5 elocation e20210818

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: avaliar a efetividade de um programa cognitivo-comportamental para controle de sintomas do trato urinário inferior pós-prostatectomia radical. Método: estudo de ensaio clínico randomizado, com 41 participantes aleatorizados em intervenção (n=20) e controle (n=21), durante três meses. O grupo intervenção recebeu o programa cognitivo-comportamental, enquanto o grupo controle recebeu orientações de rotina do serviço. As variáveis desfechos foram intensidade da incontinência urinária e sintomas do trato urinário inferior, avaliados pelo Pad-Test e Urinary Incontinence Scale of Radical Prostatectomy e King’s Health Questionnaire. Resultados: ao final do estudo, o grupo intervenção apresentou menor intensidade da incontinência urinária (p≤0,001), e houve menos chances de apresentar alterações da frequência urinária (p≤0,001), urgência miccional (p≤0,001), noctúria (p=0,005), incontinência urinária de esforço (p≤0,001) e urge-incontinência (p≤0,045). Conclusão: o programa cognitivo-comportamental foi efetivo para a redução de sintomas do trato urinário inferior após a prostatectomia radical. Registro Brasileiro de Ensaios Clínicos: RBR-3sstqg.

ABSTRACT Objective: to assess the effectiveness of a cognitive-behavioral program to control lower urinary tract symptoms after radical prostatectomy. Methods: a randomized clinical trial study, with 41 participants randomized into intervention (n=20) and control (n=21), for three months. The intervention group received the cognitive-behavioral program, while the control group received routine guidance from the service. Outcome variables were urinary incontinence intensity and lower urinary tract symptoms, assessed by the Pad-Test and Urinary Incontinence Scale of Radical Prostatectomy and King’s Health Questionnaire. Results: at the end of the study, the intervention group had a lower urinary incontinence intensity (p≤0.001), and there were less chances of presenting changes in urinary frequency (p≤0.001), urinary urgency (p≤0.001), nocturia (p=0.005), stress urinary incontinence (p≤0.001) and urge incontinence (p≤0.045). Conclusion: the cognitive-behavioral program was effective in reducing lower urinary tract symptoms after radical prostatectomy. Brazilian Clinical Trial Registry: RBR-3sstqg.

RESUMEN Objetivo: evaluar la efectividad de un programa cognitivo-conductual para controlar los síntomas del tracto urinario inferior después de la prostatectomía radical. Métodos: estudio de ensayo clínico aleatorizado, con 41 participantes aleatorizados en intervención (n=20) y control (n=21), durante tres meses. El grupo de intervención recibió el programa cognitivo-conductual, mientras que el grupo control recibió orientación rutinaria del servicio. Las variables de resultado fueron la intensidad de la incontinencia urinaria y los síntomas del tracto urinario inferior, evaluados mediante Pad-Test y Urinary Incontinence Scale of Radical Prostatectomy y King’s Health Questionnaire. Resultados: al final del estudio, el grupo intervención presentó menor intensidad de incontinencia urinaria (p≤0,001), y hubo menos posibilidades de presentar cambios en la frecuencia urinaria (p≤0,001), urgencia urinaria (p≤0,001), nicturia (p=0,005), incontinencia urinaria de esfuerzo (p≤0,001) e incontinencia de urgencia (p≤0,045). Conclusión: el programa cognitivo-conductual fue eficaz para reducir los síntomas del tracto urinario inferior después de la prostatectomía radical. Registro Brasileño de Ensayos Clínicos: RBR-3sstqg.

https://doi.org/10.1590/0034-7167-2021-0818

11.

Grain processing, adaptability, and stability of red rice cultivars
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Lima, Rafael Hydalgo Passeri

; Souza, Alexandre Gomes de

; Menezes, Bruna Rafaela da Silva

; Lopes, Higino Marcos

; Moreira, Luiz Beja

; Pereira, Maurício Ballesteiro

Ciência Rural

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2022, Volume 52 N. 12 elocation e20210418

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O arroz vermelho é um tipo especial de arroz que devido a atributos benéficos a saúde é consumido na forma integral e tornou-se uma opção de diversificação de cultivo. Diversos fatores durante o desenvolvimento da planta podem afetar o rendimento de beneficiamento. Com isso, o objetivo deste trabalho foi avaliar a adaptabilidade, estabilidade e beneficiamento de grãos de cultivares de arroz vermelho e compará-la a de arroz branco produzidas nos municípios de Campos dos Goytacazes, Seropédica e Pinheiral, RJ, durante os anos agrícolas de 2016/2017 e 2017/2018. Os tratamentos foram duas cultivares de arroz branco (BRS Esmeralda e IAC 201) e duas de arroz vermelho (ENA-AR1601 e Virgínia), distribuídos no campo sob o delineamento em blocos ao acaso, com cinco repetições. Foram avaliadas a produtividade, classe do grão, o rendimento de engenho e de grãos inteiros. As médias das cultivares em diferentes locais e anos foram comparadas pelo teste de Tukey (P< 0,05). Foi adotada a metodologia recomendada por Eberhart e Russell para estimativa dos parâmetros de adaptabilidade e estabilidade. A classificação dos grãos das cultivares ENA-AR1601 e Virgínia foi médio e longo, respectivamente. As cultivares de arroz vermelho ENA-AR 1601 e Virgínia apresentaram desempenho produtivo superior a média nacional. As cultivares de arroz vermelho e BRS Esmeralda apresentaram comportamento altamente previsível de acordo ao estímulo ambiental. Com valores médios de 62%, nos dois anos avaliados, as cultivares de arroz vermelho apresentaram excelente rendimento de beneficiamento.

ABSTRACT: Red rice is consumed in whole grain form due to its beneficial nutritional attributes and has become an option for crop diversification. Several factors during plant development can affect the crop’syield. This study evaluated the adaptability and stability of the post-harvest processing of red rice cultivars and compare them with those of white rice cultivars grown in the municipalities of Campos dos Goytacazes, Seropédica, and Pinheiral, RJ, between 2016 and 2018. Two white rice (BRS Esmeralda and IAC 201) and two red rice cultivars (ENA-AR1601 and Virginia) were distributed in the field under randomized block design with five repetitions. Yield, grain class, ingenuity, and whole grain yield were evaluated. The means of these parameters for cultivars in different locations and years were compared by Tukey’s test (P < 0.05). The Eberhart and Russell regression model was used to estimate the adaptability and stability parameters. The grain classification of the cultivars ENA-AR1601 and Virginia was medium and long, respectively. The red rice cultivars ENA-AR 1601 and Virginia showed higher productive performance than the national average. The red rice cultivars and BRS Esmeralda showed highly predictable behavior based on the environmental stimulus. With average values of 62% in the two years evaluated, the red rice cultivars showed excellent processing yield.

https://doi.org/10.1590/0103-8478cr20210418

12.

Contribuições da Noção de Crise do Senso Comum na Esquizofrenia em Stanghellini
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Monteiro, Victor

; Souza, Camila

; Pita, Juliana

; Moreira, Virginia

Psicologia: Teoria e Pesquisa

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2022, Volume 38 elocation e38416

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A noção de crise do senso comum na esquizofrenia é introduza por Wolfgang Blankenburg através do conceito de perda da evidência natural. Na contemporaneidade, Giovanni Stanghellini revista e amplia essa noção, propondo uma perspectiva panorâmica dessa crise. Este artigo apresenta as contribuições trazidas pela perspectiva de Stanghellini, introduzindo seu entendimento sobre o conceito de senso comum e a relevância deste para a compreensão da esquizofrenia. Para o autor, o senso comum é compreendido de três modos: como saber socialmente compartilhado, sintonização intuitiva e cenestesia. Através das noções de intercorporeidade e koinè aisthesis, Stanghellini entende a esquizofrenia como experiência de rompimento da relação habitual com o mundo. Sua proposta contribui para a prática clínica ao sugerir direções à psicoterapia com esquizofrênicos.

Abstract The notion of crisis of common sense on schizophrenia is introduced by Wolfgang Blankenburg through his concept of loss of natural evidence. In contemporaneity, Giovanni Stanghellini revisits and amplifies this notion by proposing a panoramic perspective on this crisis. This paper presents the contributions brought by Stanghellini’s perspective, introducing his understanding of common sense and its relevance for the comprehension of schizophrenia. For the author, common sense is understood in three ways: as a knowledge socially shared, intuitive attunement, and cenesthesia. Through the notions of intercorporeality and koinè aisthesis, Stanghellini conceives schizophrenia as an experience of disruption of the habitual relation with the world. His proposal contributes to clinical practice by suggesting directions for the psychotherapy with schizophrenics.

https://doi.org/10.1590/0102.3772e38416.pt

13.

Translation, cross-cultural adaptation, and validation of the Canadian Diabetes Risk Questionnaire for the Brazilian population
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Lourenço, Ingrid Mendonça

; Rêgo, Adriana Sousa

; Diniz, Jocielma Garcez

; Bena, Maryângela Godinho Pereira

; Moreira, Weslley da Silva Barbosa

; Ferreira, Patrícia Rodrigues

; Soares, Karla Virgínia Bezerra de Castro

; Almeida, Lucivalda Viegas de

; Tavarez, Rudys Rodolfo de Jesus

; Bassi-Dibai, Daniela

Revista da Associação Médica Brasileira

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dec 2021, Volume 67 N. 12 Pages 1810 - 1815

Abstract: En | Text: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to translate, cross-culturally adapt, and validate the Canadian Diabetes Risk Questionnaire for use in Brazilian Portuguese. METHODS: This is a Questionnaire validity study conducted at a private university. The Brazilian version of the Canadian Diabetes Risk Questionnaire was developed by means of the processes of translation, back-translation, committee review, and pretesting. Test-retest reliability was measured using the intraclass correlation coefficient and kappa coefficient. Internal consistency was measured using Cronbach's alpha. For construct validity, the total score of the Canadian Diabetes Risk Questionnaire was correlated with the Diabetes Knowledge Scale and the Diabetes Mellitus Risk Questionnaire. Ceiling and floor effects were also evaluated in the present study. RESULTS: For construct validity and floor and ceiling effect measurements, a total sample of 100 participants was used. For reliability, a subsample of 34 participants out of the total sample was used. We identified adequate values for reliability (kappa between 0.46–1.00 and ICC 0.96) and internal consistency (Cronbach's alpha 0.80). There were significant correlations between the Canadian Diabetes Risk Questionnaire and the Diabetes Mellitus Risk Questionnaire (rs=0.370, p<0.001), but not the Diabetes Knowledge Scale (rs= −0.162). No ceiling or floor effects were found. CONCLUSION: We concluded that in accordance with the best international recommendations, the Brazilian version of the Canadian Diabetes Risk Questionnaire has adequate psychometric properties.

https://doi.org/10.1590/1806-9282.20210738

14.

Mídia audiovisual no interior do Brasil e produção local de informação
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Moreira, Sonia Virgínia

; Del Bianco, Nélia Rodrigues

; Martins, Cézar Franco dos Santos

Intercom: Revista Brasileira de Ciências da Comunicação

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aug 2021, Volume 44 N. 2 Pages 113 - 135

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este artigo se propõe a verificar a existência ou inexistência de produção local de conteúdo informativo em emissoras de rádio e em retransmissoras de rádio e TV no universo dos 32 municípios brasileiros de IDHM Muito Baixo localizados nas regiões Norte e Nordeste. A abordagem desses municípios emprega conceitos de mídia local e de jornalismo de proximidade para fundamentar a análise dos meios nas localidades. Os arranjos territoriais de mídia e de produção de informação em emissoras e retransmissoras locais são os objetos pesquisados. A consulta a textos legais e a observação empírica do conteúdo (re)produzido por emissoras de rádio nos municípios estudados sugerem que há um direcionamento, natural ou intencional, na implantação de sistemas de reprodução da informação originada de cidades médias ou centros urbanos. Os conceitos usados são: territórios, mídia local e “desertos de notícias”.

Abstract The purpose of this article is to verify whether there is or there is not local news content being produced by radiobroadcasters and by radio and TV re-broadcasters in the 32 municipalities with very low development indicators (Very Low IDHM), all of them in the North and in the Northeast regions. The scope of the study was determined by the lack of information either on media practices or local characteristics, which entailed the use of local media and local journalism concepts to advance the field analysis. The article considers territorial arrangements and media arrangements in observing the production of radio and RTV re-broadcasters. Legal and policies documents and empirical observation suggest that there is a direction (natural or intentional) in establishing a system of reproduction of information from other media in larger cities. The concepts used are territories, local media, and “news desert”.

Resumen El objetivo de este artículo es verificar la existencia o no de producción local de contenidos informativos en las emisoras de radio y retransmisoras de radio y televisión en 32 municipios en Brasil con indicadores muy bajo (IDHM Muito Baixo) ubicados en las regiones Norte y Nordeste. El enfoque de estos municipios impone el uso de conceptos que apoyan los argumentos del análisis de datos de los medios de comunicación relacionados con estas localidades. El estudio observa los arreglos territoriales de medios y de producción de información en el ámbito de las emisoras de radio y retransmisoras de radio y TV. La consulta de los textos legales y la observación empírica de los contenidos producidos por las emisoras de radio en las ciudades estudiadas sugieren que existe una dirección (natural o intencional) de un sistema para la reproducción de la información de las ciudades medianas o grandes. Los conceptos utilizados son: territorios, noticia local y “desierto de noticias”.

https://doi.org/10.1590/1809-5844202126 206 downloads

15.

Perfil del riesgo de brotes alimentarios por intoxicación estafilocócica en Cuba
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Dueñas Moreira, Odeite

; Puig Peña, Yamila

; Romero Placeres, Manuel

; Gámez Sánchez, Donelia

; Puñales Sosa, Osvaldo V

; Leyva Castillo, Virginia

Revista Cubana de Medicina Tropical

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apr 2021, Volume 73 N. 1 elocation e514

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Staphylococcus is a frequent cause of food poisoning. In Cuba it is one of the main causes of outbreaks. Objective: Analyze the risk profile of staphylococcal food poisoning outbreaks in Cuba. Methods: An observational analytical study was conducted about hygienic and epidemiological factors associated to the risk for staphylococcal food poisoning in Cuba. The study was carried out at the National Institute of Hygiene, Epidemiology and Microbiology from January to November 2018. The information was obtained from a systematic bibliographic review, analysis of data from the Medical Microbiology National Reference Laboratory, and outbreak reports from the National Environmental Health Division. Microbiological risk was estimated with Ross-Sumner semi-quantitative software. Results: The main hazard identified was Staphylococcus aureus, enterotoxin A producers and determination of antimicrobial resistant isolates like methicillin-resistant Staphylococcus aureus. The food items most commonly involved were sweets, and safety was most frequently affected by cross-contamination in 31.4% of the outbreaks and inadequate preservation in 46.1%. Prediction of members of the population of interest becoming ill every year was 6 260. Conclusions: Risk for the occurrence of staphylococcal food poisoning outbreaks was considered to be high; surveillance is recommended of food items requiring direct manipulation and appropriate thermal treatment is not applied before consumption, with risk management actions aimed at manufacturers and consumers.

RESUMEN Introducción: Staphylococcus ocasiona con frecuencia intoxicaciones alimentarias; en Cuba es una de las principales causas de brotes. Objetivo: analizar el perfil del riesgo de brotes alimentarios por Staphylococcus en Cuba. Métodos: Se realizó un estudio observacional analítico sobre los factores higiénicos y epidemiológicos asociados al riesgo de la intoxicación alimentaria por Staphylococcus en Cuba, en el Instituto Nacional de Higiene Epidemiología y Microbiología, durante el periodo de enero a noviembre de 2018. La información se obtuvo mediante revisión bibliográfica sistémica, análisis de datos del Laboratorio de Referencia Nacional en Microbiología Sanitaria y informes de brotes de la Dirección Nacional de Salud Ambiental. Se estimó el riesgo microbiológico mediante el programa semicuantitativo Ross-Sumner. Resultados: Se identificó como principal peligro Stahylococcus aureus, productores de enterotoxina A y la determinación de aislamientos resistentes a los antimicrobianos, como Stahylococcus aureus meticilina resistentes. Los alimentos más implicados fueron los productos de repostería y la inocuidad se afectó en mayor frecuencia por la contaminación cruzada en el 31,4 % brotes y la inadecuada conservación en 46,1 %. La predicción de personas que enferman por año en la población de interés fue de 6 260. Conclusiones: El riesgo de la ocurrencia de brotes por Staphylococcus se estimó como alto; la vigilancia se recomienda en alimentos que requieren manipulación directa y no se aplica tratamiento térmico antes del consumo, con gestiones de riesgo dirigidas a productores y consumidores.

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